Corrigendum to: Complications in pulmonary vein isolation in the Netherlands Heart Registration differ with sex and ablation technique

Abstract Aims S100B, a well-known damage-associated molecular pattern protein is released acutely by central and peripheral nerves and upon concomitant denervation in pulmonary vein isolation (PVI). We aimed to investigate whether the ablation technique used for PVI impacts S100B release in patients with paroxysmal atrial fibrillation (AF). Methods and results The study population consisted of 73 consecutive patients (age: 62.7 ± 10.9 years, 54.8% males) undergoing first-time PVI with either radiofrequency (RF; n = 30) or cryoballoon (CB; n = 43) for paroxysmal AF. S100B determined from venous plasma samples taken immediately before and after PVI increased from 33.5 ± 1.8 to 91.1 ± 5.3 pg/mL (P < 0.0001). S100B release in patients undergoing CB-PVI was 3.9 times higher compared to patients with RF-PVI (ΔS100B: 21.1 ± 2.7 vs. 83.1 ± 5.2 pg/mL, P < 0.0001). During a mean follow-up of 314 ± 186 days, AF recurrences were observed in 18/71 (25.4%) patients (RF-PVI: n = 9/28, CB-PVI: n = 9/43). Univariate Cox regression analysis indicated that an increase in S100B was associated with higher freedom from AF in follow-up (hazard ratio per 10 pg/mL release of S100B: 0.83; 95% confidence interval: 0.72–0.95; P = 0.007). Conclusion The ablation technique used for PVI has an impact on the release of S100B, a well-established biomarker for neural damage.

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Cryoballoon Pulmonary Vein Isolation Guided by Transesophageal Echocardiography: Novel Aspects on an Emerging Ablation Technique

Journal of Cardiovascular Electrophysiology ◽

10.1111/j.1540-8167.2009.01524.x ◽

2009 ◽

Vol 20 (11) ◽

pp. 1197-1202 ◽

Cited By ~ 38

Author(s):

CLAUDIA HERRERA SIKLÓDY ◽

JAN MINNERS ◽

MARTIN ALLGEIER ◽

HANS-JÜRGEN ALLGEIER ◽

NIKOLAUS JANDER ◽

...

Keyword(s):

Transesophageal Echocardiography ◽

Pulmonary Vein ◽

Pulmonary Vein Isolation ◽

Ablation Technique

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Complications in pulmonary vein isolation in the Netherlands Heart Registration differ with sex and ablation technique

EP Europace ◽

10.1093/europace/euaa255 ◽

2020 ◽

Author(s):

Daniel Mol ◽

Saskia Houterman ◽

Jippe C Balt ◽

Rohit E Bhagwandien ◽

Yuri Blaauw ◽

...

Keyword(s):

Atrial Fibrillation ◽

The Netherlands ◽

Cardiac Tamponade ◽

Pulmonary Vein ◽

Pulmonary Vein Isolation ◽

Vascular Complications ◽

Bleeding Complications ◽

Invasive Treatment ◽

Female Sex

Abstract Aims Pulmonary vein isolation (PVI) has become a cornerstone of the invasive treatment of atrial fibrillation. Severe complications are reported in 1–3% of patients. This study aims to compare complications and follow-up outcome of PVI in patients with atrial fibrillation. Methods and results The data were extracted from the Netherlands Heart Registration. Procedural and follow-up outcomes in patients treated with conventional radiofrequency (C-RF), multielectrode phased RF (Ph-RF), or cryoballoon (CB) ablation from 2012 to 2017 were compared. Subgroup analysis was performed to identify variables associated with complications and repeat ablations. In total, 13 823 patients (69% male) were included. The reported complication incidence was 3.6%. Patients treated with C-RF developed more cardiac tamponades (C-RF 0.8% vs. Ph-RF 0.3% vs. CB 0.3%, P ≤ 0.001) and vascular complications (C-RF 1.7% vs. Ph-RF 1.2% vs. CB 1.3%, P ≤ 0.001). Ph-RF was associated with fewer bleeding complications (C-RF: 1.0% vs. Ph-RF: 0.4% vs. CB: 0.7%, P = 0.020). Phrenic nerve palsy mainly occurred in patients treated with CB (C-RF: 0.1% vs. Ph-RF: 0.2% vs. CB: 1.5%, P ≤ 0.001). In total, 18.4% of patients were referred for repeat ablation within 1 year. Female sex, age, and CHA2DS2-VASc were independent risk factors for cardiac tamponade and bleeding complications, with an adjusted OR for female patients of 2.97 (95% CI 1.98–4.45) and 2.02 (95% CI 1.03–4.00) respectively. Conclusion The reported complication rate during PVI was low. Patients treated with C-RF ablation were more likely to develop cardiac tamponades and vascular complications. Female sex was associated with more cardiac tamponade and bleeding complications.

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Atrial Fibrillation Ablation: Outcomes of Pulmonary Vein Isolation using the Cryoballoon Ablation Technique

Heart Lung and Circulation ◽

10.1016/j.hlc.2011.05.224 ◽

2011 ◽

Vol 20 ◽

pp. S90

Author(s):

A. Sepahpour ◽

S. Singarayar ◽

M. McGuire

Keyword(s):

Atrial Fibrillation ◽

Pulmonary Vein ◽

Pulmonary Vein Isolation ◽

Atrial Fibrillation Ablation ◽

Cryoballoon Ablation ◽

Ablation Technique

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Impact of pulmonary veins anatomy on outcome of cryoablation or radiofrequency catheter ablation for atrial fibrillation

EP Europace ◽

10.1093/europace/euab116.252 ◽

2021 ◽

Vol 23 (Supplement_3) ◽

Author(s):

G Silva ◽

P Queiros ◽

M Silva ◽

R Teixeira ◽

J Almeida ◽

...

Keyword(s):

Atrial Fibrillation ◽

Catheter Ablation ◽

Pulmonary Vein ◽

Pulmonary Vein Isolation ◽

Pulmonary Veins ◽

Ca 125 ◽

Common Trunk ◽

Interventional Treatment ◽

Ablation Technique ◽

Af Recurrence

Abstract Funding Acknowledgements Type of funding sources: None. BACKGROUND Pulmonary vein isolation is the cornerstone of interventional treatment of atrial fibrillation (AF). Pulmonary veins frequently display anatomic variants. If this influences the recurrence of AF after catheter ablation is still a matter of debate. PURPOSE Our aim was to determine if pulmonary vein anatomy variants influences the recurrence of AF after catheter ablation with radiofrequency or cryoablation. METHODS Retrospective analysis of patients with paroxysmal or persistent atrial fibrillation who underwent pulmonary vein isolation by radiofrequency (RF) or cryoablation (CA) in a single center between January 2017 and September 2019. All patients underwent computed tomography before AF ablation. Within each treatment group (RF or CA), patients were stratified according to their PV anatomy in: regular (2 left PVs and 2 right PVs) or variant (left common trunk, right common trunk, bilateral common trunk, right intermediate branch or other). The primary end-point was 1-year recurrence of AF. Recurrence was defined as electrical documented AF. RESULTS A total of 425 patients (RF = 300 and CA = 125), aged 56.6 ± 11.7 years, 277 men (65.0%) were enrolled. The majority of patients had paroxysmal AF (n = 343, 81.5%). Mean CHA2DS2-VASc score was 1.12 ± 1.28. Regular PV anatomy was identified in 357 patients (84.0%), a left common trunk in 53 patients (12.5%), a bilateral common trunk in 5 patients (1.2%), a right intermediate branch in 3 patients (0.7%) and other mixed variants in 7 patients (1.6%). There were no significant differences in the baseline clinical and echocardiographic characteristics between groups. At 1-year follow-up, patients with atypical PV anatomy had more AF recurrence (regular 8.1% vs variant 16.2%; p = 0.037). Analyzing according to the ablation technique there was no difference in AF recurrence between PV anatomy groups in patients submitted to radiofrequency (regular 8.3% vs variant 13.0%; p = 0.224). On the other hand, in cryoablation group, patients with PV anatomic variant had significantly higher rates of 1-year AF recurrence (regular 7.8% vs variant 22.8%; p= 0.033). CONCLUSION The presence of atypical PVs anatomy seems to be associated with higher rates of AF recurrence at 1-year in patients undergoing cryoablation. Further prospective studies are needed to confirm the PV anatomy impact in the success of the procedure and if this needs to be accounted in the choice of ablation technique. Abstract Figure. Recurrence in AF after cryoablation

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Pulmonary vein isolation using cryoballoon technique in atrial fibrillation patient after Greenfield vena cava filter implantation

Global Cardiology Science and Practice ◽

10.21542/gcsp.2020.21 ◽

2020 ◽

Vol 2020 (2) ◽

Author(s):

Shaojie Chen ◽

Boris Schmidt ◽

Stefano Bordignon ◽

Shota Tohoku ◽

K R Julian Chun

Keyword(s):

Atrial Fibrillation ◽

Pulmonary Vein ◽

Pulmonary Vein Isolation ◽

Second Generation ◽

Atrial Fibrillation Patient ◽

Pulmonary Veins ◽

Vena Cava ◽

Vena Cava Filter ◽

Cryoballoon Ablation ◽

Ablation Technique

Background: Cryoballoon ablation is an established procedure for atrial fibrillation (AF). Patient with vena cava filter undergoing pulmonary vein isolation (PVI) were seldom reported.Case presentation: We describe an AF ablation technique using the second generation cryoballoon in a patient after vena cava filter implantation. All pulmonary veins were successfully isolated without complication.Conclusions: For AF patient with previously implanted vena cava filter, cryoballoon based PVI appears feasible and safe.

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