Longitudinal association of short-term, metronome-paced heart rate variability and echocardiographically assessed cardiac structure at a 4-year follow-up: results from the prospective, population-based CARLA cohort

BackgroundPeople with depression tend to have lower heart rate variability (HRV), but the temporal sequence is poorly understood. In a sample of the general population, we prospectively examined whether HRV measures predict subsequent depressive symptoms or whether depressive symptoms predict subsequent levels of HRV.MethodData from the fifth (1997–1999) and ninth (2007–2009) phases of the UK Whitehall II longitudinal population-based cohort study were analysed with an average follow-up of 10.5 years. The sample size for the prospective analysis depended on the analysis and ranged from 2334 (644 women) to 2276 (602 women). HRV measures during 5 min of supine rest were obtained. Depressive symptoms were evaluated by four cognitive symptoms of depression from the General Health Questionnaire.ResultsAt follow-up assessment, depressive symptoms were inversely associated with HRV measures independently of antidepressant medication use in men but not in women. Prospectively, lower baseline heart rate and higher HRV measures were associated with a lower likelihood of incident depressive symptoms at follow-up in men without depressive symptoms at baseline. Similar but statistically insignificant associations were found in women. Adjustments for known confounders including sociodemographic and lifestyle factors, cardiometabolic conditions or medication did not change the predictive effect of HRV on incident depressive symptoms at follow-up. Depressive symptoms at baseline were not associated with heart rate or HRV at follow-up in either sex.ConclusionsThese findings are consistent with an aetiological role of the autonomic nervous system in depression onset.

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Effect of short-term heart rate variability biofeedback on long-term abstinence in alcohol dependent patients – a one-year follow-up

BMC Psychiatry ◽

10.1186/s12888-017-1480-2 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 9

Author(s):

Ana Isabel Penzlin ◽

Kristian Barlinn ◽

Ben Min-Woo Illigens ◽

Kerstin Weidner ◽

Martin Siepmann ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Short Term ◽

Heart Rate Variability Biofeedback ◽

One Year ◽

Alcohol Dependent

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Prognostic relevance of the interaction between short-term, metronome-paced heart rate variability, and inflammation: results from the population-based CARLA cohort study

EP Europace ◽

10.1093/europace/euv333 ◽

2016 ◽

pp. euv333 ◽

Cited By ~ 2

Author(s):

Daniel Medenwald ◽

Cees A. Swenne ◽

Harald Loppnow ◽

Jan A. Kors ◽

Diana Pietzner ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Cohort Study ◽

Population Based ◽

Short Term ◽

Prognostic Relevance

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Short-Term Heart Rate Variability in a Population-Based Sample of 10-Year-Old Children

Pediatric Cardiology ◽

10.1007/s00246-014-0962-y ◽

2014 ◽

Vol 36 (1) ◽

pp. 41-48 ◽

Cited By ~ 21

Author(s):

Denise C. Jarrin ◽

Jennifer J. McGrath ◽

Paul Poirier ◽

Louise Séguin ◽

Richard E. Tremblay ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Population Based ◽

Short Term

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Heart Rate and Heart Rate Variability Changes Are Not Related to Future Cardiovascular Disease and Death in People With and Without Dysglycemia: A Downfall of Risk Markers? The Whitehall II Cohort Study

10.2337/figshare.13526351.v1 ◽

2021 ◽

Author(s):

Christian S Hansen ◽

Marit E Jørgensen ◽

Marek Malik ◽

Daniel R Witte ◽

Eric J Brunner ◽

...

Keyword(s):

Cardiovascular Disease ◽

Heart Rate ◽

Heart Rate Variability ◽

Cohort Study ◽

Population Based ◽

Increased Risk ◽

All Cause Mortality ◽

Future Events ◽

Design And Methods

Objective Higher resting heart rate (rHR) and lower heart rate variability (HRV) are associated with increased risk of cardiovascular disease (CVD) and all-cause mortality in people with and without diabetes It is unknown whether temporal changes in rHR and HRV may contribute to this risk. We investigated associations between 5-year changes in rHR and HRV and risk of future CVD and death, taking into account participants’ baseline glycemic state. Research design and Methods In this prospective population-based cohort study we investigated 4,611 CVD-free civil servants (mean age 60, SD=5.9 years, 70% men). rHR and/or 6 indices of HRV were measured. Associations of 5-year change in 5-minute rHR and HRV with fatal- and non-fatal CVD and all-cause mortality or the composite of the two were assessed with adjustments for relevant confounders. Effect modification by glycemic state was tested. Results At baseline, 63% of participants were normoglycemic, 29% had prediabetes and 8% had diabetes. During a median (IQR) follow-up of 11.9 (11.4;12.3) years, 298 participants (6.5%) experienced a CVD event and 279 (6.1%) died from non-CVD related causes. We found no association between 5-year changes in rHR and HRV and future events. Only baseline rHR was associated with all-cause mortality. A 10 beats per minute higher baseline level showed a 11.4% higher rate of all-cause mortality (95%CI:1.0;22.9%, P=0.032). Glycemic state did not modify associations. Conclusion Changes in rHR and HRV and possibly also baseline values of these measures are not associated with future CVD or mortality in people with or without dysglycemia.

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Heart Rate and Heart Rate Variability Changes Are Not Related to Future Cardiovascular Disease and Death in People With and Without Dysglycemia: A Downfall of Risk Markers? The Whitehall II Cohort Study

10.2337/figshare.13526351 ◽

2021 ◽

Author(s):

Christian S Hansen ◽

Marit E Jørgensen ◽

Marek Malik ◽

Daniel R Witte ◽

Eric J Brunner ◽

...

Keyword(s):

Cardiovascular Disease ◽

Heart Rate ◽

Heart Rate Variability ◽

Cohort Study ◽

Population Based ◽

Increased Risk ◽

All Cause Mortality ◽

Future Events ◽

Design And Methods

Objective Higher resting heart rate (rHR) and lower heart rate variability (HRV) are associated with increased risk of cardiovascular disease (CVD) and all-cause mortality in people with and without diabetes It is unknown whether temporal changes in rHR and HRV may contribute to this risk. We investigated associations between 5-year changes in rHR and HRV and risk of future CVD and death, taking into account participants’ baseline glycemic state. Research design and Methods In this prospective population-based cohort study we investigated 4,611 CVD-free civil servants (mean age 60, SD=5.9 years, 70% men). rHR and/or 6 indices of HRV were measured. Associations of 5-year change in 5-minute rHR and HRV with fatal- and non-fatal CVD and all-cause mortality or the composite of the two were assessed with adjustments for relevant confounders. Effect modification by glycemic state was tested. Results At baseline, 63% of participants were normoglycemic, 29% had prediabetes and 8% had diabetes. During a median (IQR) follow-up of 11.9 (11.4;12.3) years, 298 participants (6.5%) experienced a CVD event and 279 (6.1%) died from non-CVD related causes. We found no association between 5-year changes in rHR and HRV and future events. Only baseline rHR was associated with all-cause mortality. A 10 beats per minute higher baseline level showed a 11.4% higher rate of all-cause mortality (95%CI:1.0;22.9%, P=0.032). Glycemic state did not modify associations. Conclusion Changes in rHR and HRV and possibly also baseline values of these measures are not associated with future CVD or mortality in people with or without dysglycemia.

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