scholarly journals INHERITANCE OF HAIR CONSTRICTIONS IN MICE

Genetics ◽  
1972 ◽  
Vol 70 (4) ◽  
pp. 631-637
Author(s):  
Stanley J Mann ◽  
William E Straile
Keyword(s):  
Genetic Analysis ◽  
Structural Feature ◽  
Inbred Mice ◽  
Autosomal Gene ◽  
Maternal Factors ◽  
Hair Coat ◽  
Cba Mice ◽  
Respective Parent ◽  
C57bl Mice ◽  
Mode Of Inheritance

ABSTRACT The frequencies of multi-constricted hairs in the pelage is the same (75%) in the caudal mid-dorsum of C57BL/10 and CBA inbred mice, but there are more single-constricted hairs in C57BL mice (9.41%) than in CBA mice (0.13%). This structural feature is used as a basis for genetic analysis of the hair coat.—The frequency of single-constricted hairs (4.41%) in F1 mice is intermediate between the frequencies observed in the CBA and C57BL parent strains. Data from the F2 crosses and backcrosses to the respective parent strains indicate that the presence of numerous single-constricted hairs in the pelage is an inherited characteristic. The mode of inheritance is controlled primarily by a semi-dominant autosomal gene (single-constriction; Hct), without the involvement of maternal factors.

Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism

2002 ◽  
Vol 282 (2) ◽  
pp. R358-R365 ◽  
Author(s):  
D. J. Kennaway ◽  
A. Voultsios ◽  
T. J. Varcoe ◽  
R. W. Moyer
Keyword(s):  
Light Pulse ◽  
Early Morning ◽  
Laboratory Mice ◽  
Adrenergic Stimulation ◽  
Adrenergic Agonist ◽  
Pineal Melatonin ◽  
Cba Mice ◽  
Light Pulses ◽  
C57bl Mice ◽  
Melatonin Production

There has been relatively little research conducted on pineal melatonin production in laboratory mice, in part, due to the lack of appropriate assays. We studied the pineal and plasma rhythm, response to light, adrenergic stimulation, and metabolism of melatonin in CBA mice. With the use of a sensitive and specific melatonin RIA, melatonin was detected in the pineal glands at all times of the day >21 fmol/gland in CBA mice but not in C57Bl mice. Both plasma and pineal melatonin levels peaked 2 h before dawn in a 12:12-h light-dark photoperiod (162 ± 31 pM and 1,804 ± 514 fmol/gland, respectively). A brief light pulse (200 lx/15 min), 2 h before lights on, suppressed both plasma and pineal melatonin to near basal levels within 30 min. Exposure to light pulses 4 h after lights off or 2 h before lights on resulted in delays and advances, respectively, in the early morning decline of plasma and pineal melatonin on the next cycle. Administration of the β-adrenergic agonist isoproterenol (20 mg/kg) 2 and 4 h after lights on in the morning resulted in a fivefold increase in plasma and pineal melatonin 2.5 to 3 h after the first injection. In the mouse, unlike the rat, melatonin was shown to be metabolized almost exclusively to 6-glucuronylmelatonin rather than 6-sulphatoxymelatonin. These studies have shown that the appropriate methodological tools are now available for studying melatonin rhythms in mice.

Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice.

1995 ◽  
Vol 109 (6) ◽  
pp. 1199-1208 ◽  
Author(s):  
Amanda J. Roberts ◽  
Tamara J. Phillips ◽  
John K. Belknap ◽  
Deborah A. Finn ◽  
L. Donald Keith
Keyword(s):  
Genetic Analysis ◽  
Recombinant Inbred ◽  
Inbred Mice ◽  
Recombinant Inbred Mice ◽  
Corticosterone Response

scholarly journals Liver tryptophan pyrrolase. A major determinant of the lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL mice

1989 ◽  
Vol 264 (2) ◽  
pp. 597-599 ◽  
Author(s):  
A A B Badawy ◽  
C J Morgan ◽  
J Lane ◽  
K Dhaliwal ◽  
D M Bradley
Keyword(s):  
Alcohol Consumption ◽  
Major Determinant ◽  
Corticosterone Concentration ◽  
Cba Mice ◽  
C57bl Mice ◽  
Biological Determinants ◽  
Tryptophan Pyrrolase ◽  
The Brain

The lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL, compared with -non-preferring CBA, mice is caused by a decrease in circulating tryptophan availability to the brain secondarily to a higher liver tryptophan pyrrolase activity associated with a higher circulating corticosterone concentration. Activity or expression of liver tryptophan pyrrolase and/or their induction by glucocorticoids may be important biological determinants of predisposition to alcohol consumption.

Genetic analysis of cerebellar folial pattern in crosses of C57BL/6J and DBA/2J inbred mice

1993 ◽  
Vol 619 (1-2) ◽  
pp. 81-88 ◽  
Author(s):  
Paul E. Neumann ◽  
John D. Garretson ◽  
George P. Skabardonis ◽  
Gary G. Mueller
Keyword(s):  
Genetic Analysis ◽  
Inbred Mice
Sign in / Sign up

Export Citation Format

Share Document