Solar Powered Infant Incubator for Assessment in Healthcare System

Monitoring baby health status in incubator is a necessary task and need more attention. Huge number of issues was happened previously like improper oxygen supply, theft of child and mishandling in continuous monitoring. Hence a proper automatic system should be needed for monitoring a baby in incubator with reduced human interaction. This can be achieved through sensors and projected as proposed system. Here temperature, humidity, heartbeat, pressure and accelerometer sensor are used to check baby body condition and if any drastic change is identified in it will be automatically intimated through buzzer. If any unauthorized person is picking up the child it will be detected by IR sensor and automatically door will be closed. Another major issue is the current status of a child is not transparent to respective parent here all the details gathered from the sensors will be automatically loaded in cloud through IoT which can viewed by their parent as well as doctor to analyze current status of the baby. The whole process is controlled by Raspberry PI and for continuous monitoring solar panel is added that provide power supply for our system sequentially without any interrupt. Hence it clearly shows that our proposed system achieves the objective of our work and protects baby both in physical and health based parameters.

Collective co-production in English public services: the case of voluntary action in primary education

In this article we explore the extent and distribution of collective co-production across the single policy area of primary education in England. While much attention has been paid to the virtue of co-production, often drawing on particular, single, case studies, there is less literature exploring the wider impacts. However, ongoing marketisation, fiscal pressures and increased competition in education have led school leaders to turn to co-production as one mechanism for survival, while recognition of some of the potential benefits has led to a surge in efforts to implement co-productive activities. Focusing on collective co-production efforts, this article explores voluntary income data from more than 300 primary schools and their respective Parent Teacher Associations, supported by 70 questionnaires looking at volunteer contributions, which were completed by headteachers, and ten in-depth interviews with headteachers. Our data reveal three significant findings: the extent of collective co-production in primary education is increasing; this activity is driven by fiscal challenges, resulting in schools feeling coerced into co-production, which has wider implications; and this is resulting in increasing inequalities. We conclude with a discussion about what this means for the wider policy agenda.

Mexican-American preschoolers as co-creators of zones of proximal development during retellings of culturally relevant stories: A participatory study

This study explores communication and retelling skills that are revealed after Mexican-American preschoolers engaged in culturally sensitive read alouds. Participants, highlighted in this article, included two four-year-old preschool children in a Spanish/English dual language classroom. The children selected culturally relevant texts and engaged in story retellings with their respective parent. The findings indicate that children co-constructed Zones of Proximal Development (ZPDs) in response to their parents' caring moves. Participants responded as cared-fors and carers as evident in their use of memorization skills and attention to detail to appropriate vocabulary and effectively retell a story. Additionally, preschoolers extended their ZPDs through imagination and inferencing by inserting events into the narrative and reading between the lines to expand and enrich the original stories. These findings have implications for reframing the way in which educators capitalize on young children's communication skills.

Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties

Antioxidants protect the structural and functional components in organisms against oxidative stress. Most antioxidants are of plant origin as the plants are permanently exposed to oxidative stress (UV radiation, photosynthetic reactions). Both carotenoids and flavonoids are prominent antioxidant and anti-radical agents often occurring together in the plant tissues and acting in lipophilic and hydrophilic milieu, respectively. They are complementary in their anti-radical activity. This study describes the synthesis of a series of hybrid ester conjugates of retinoic acid with various flavonolignans, such as silybin, 2,3-dehydrosilybin and isosilybin. Antioxidant/anti-radical activities and bio-physical properties of novel covalent carotenoid-flavonoid hybrids, as well as various mixtures of the respective parent components, were investigated. Retinoyl conjugates with silybin—which is the most important flavonolignan in silymarin complex—(and its pure diastereomers) displayed better 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity than both the parent compounds and their equimolar mixtures.

Navigating the Landscape of Tumor Extracellular Vesicle Heterogeneity

The last decade has seen a rapid expansion of interest in extracellular vesicles (EVs) released by cells and proposed to mediate intercellular communication in physiological and pathological conditions. Considering that the genetic content of EVs reflects that of their respective parent cell, many researchers have proposed EVs as a source of biomarkers in various diseases. So far, the question of heterogeneity in given EV samples is rarely addressed at the experimental level. Because of their relatively small size, EVs are difficult to reliably isolate and detect within a given sample. Consequently, standardized protocols that have been optimized for accurate characterization of EVs are lacking despite recent advancements in the field. Continuous improvements in pre-analytical parameters permit more efficient assessment of EVs, however, methods to more objectively distinguish EVs from background, and to interpret multiple single-EV parameters are lacking. Here, we review EV heterogeneity according to their origin, mode of release, membrane composition, organelle and biochemical content, and other factors. In doing so, we also provide an overview of currently available and potentially applicable methods for single EV analysis. Finally, we examine the latest findings from experiments that have analyzed the issue at the single EV level and discuss potential implications.

On the Making and Unmaking of Arab States

Since 2011, Arab states have faced unprecedented challenges to their territorial integrity. Movements in Kurdistan, southern Arabia, and Cyrenaica have all made unilateral bids to secure administrative and coercive control over territory. While some disavow secessionism, their agendas for separation clearly undermine their respective parent state, Syria, Iraq, Yemen, and Libya. Added to this is the Islamic State (IS), intent on breaking all the borders of the region and establishing a new caliphate. It is easy to see the emergence and empowerment of these movements as steps in the crumbling of artificial colonially constructed states and the reassertion of more ancient and organic clan, sect, and tribal allegiances. Yet these movements represent less a reversion to primoridialism than a reassertion of claims to self-determination that had been overridden in the course of 20th-century state formation.

Sedative-hypnotic Binding to 11β-hydroxylase

Background Etomidate potently suppresses adrenocortical steroid synthesis with potentially deleterious consequences by binding to 11β-hydroxylase and inhibiting its function. The authors hypothesized that other sedative-hypnotics currently in clinical use or under development (or their metabolites) might bind to the same site at clinically relevant concentrations. The authors tested this hypothesis by defining etomidate’s affinity for this site and the potencies with which other sedative-hypnotics (and their metabolites) inhibit etomidate binding. Methods 3H-etomidate’s binding to adrenal membranes from Sprague-Dawley rats was characterized with a filtration assay, and its dissociation constant was defined using saturation and homologous ligand competition approaches. Half-inhibitory concentrations of sedative-hypnotics and metabolites were determined from the reduction in specific 3H-etomidate binding measured in the presence of ranging sedative-hypnotic and metabolite concentrations. Results Saturation and homologous competition studies yielded 3H-etomidate dissociation constants of 40 and 21 nM, respectively. Half-inhibitory concentrations of etomidate and cyclopropyl methoxycarbonyl metomidate (CPMM) differed significantly (26 vs. 143 nM, respectively; P < 0.001), and those of the carboxylic acid (CA) metabolites etomidate-CA and CPMM-CA were greater than or equal to 1,000× higher than their respective parent hypnotics. The half-inhibitory concentration of dexmedetomidine was 2.2 µM, whereas those of carboetomidate, ketamine, and propofol were greater than or equal to 50 µM. Conclusion Etomidate’s in vitro dissociation constant for 11β-hydroxylase closely approximates its in vivo adrenocortical half-inhibitory concentration. CPMM produces less adrenocortical suppression than etomidate not only because it is metabolized faster but also because it binds to 11β-hydroxylase with lower affinity. Other sedative-hypnotics and metabolites bind to 11β-hydroxylase and inhibit etomidate binding only at suprahypnotic concentrations.

History of the Juliusruh ionospheric observatory on Rügen

The history of the Juliusruh ionospheric observatory on Rügen is closely connected to the history of ground-based ionospheric sounding. After a short introduction to the ionospheric research and the sounding technique, the founding of the Juliusruh station in 1954 and its development until today are described. The different methods of ground-based sounding – as far as they apply to Juliusruh – are briefly discussed. The condition of life and work in a small team on the island of Rügen, remote from the respective parent institute, is also the subject of this article, whose author headed Juliusruh Station from 1965 to 2004.

Improving energy relay dyes for dye-sensitized solar cells by use of a group of uniform materials based on organic salts (GUMBOS)

Energy relay dyes based on GUMBOS displayed improved characteristics in comparison to respective parent dyes including solubility and solar efficiency.

Seed development following reciprocal crossing among autotetraploid and diploid Acacia mangium and diploid A. auriculiformis

As part of a program to breed sterile triploid varieties of tropical Acacia, a series of inter-and intra-specific crosses were made among clones of neo-tetraploid A. mangium (AM-4x) and diploid A. mangium (AM-2x) and A. auriculiformis (AA-2x). The present paper reports variation in seed-crop development from anthesis to harvest, in comparison with that after open pollination of the respective parent trees. Abscission of spikes and pods within spikes commenced soon after anthesis and was more rapid in inter-cytotype crosses than in open-pollinated controls. Less than 12% of spikes were retained to maturity in either cytotype, emphasising the likely importance of resource competition during development. Inter-cytotype crosses showed higher levels of abnormal ovule development at 7 weeks after pollination and more undeveloped seeds in those pods which did develop to maturity. No inter-cytotype combination produced more than one viable seed per pod on average, and all needed to be germinated in vitro to survive. A directional effect was apparent in the inter-cytotype crosses within AM but this was not obvious when the cross was inter-specific. The study contributes new knowledge of the post-anthesis timeline for ovule, pod and spike abscission and discusses the likely genetic and environmental causes of observed differences between inter-and intra-cytotype crosses as well as the implications for breeding.