scholarly journals Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese

2001 ◽  
Vol 10 (13) ◽  
pp. 1379-1386 ◽  
Author(s):  
K. Sakai
Keyword(s):  
Linkage Analysis ◽  
Thyroid Disease ◽  
Hashimoto’S Thyroiditis ◽  
Autoimmune Thyroid Disease ◽  
Hashimoto's Thyroiditis ◽  
Susceptibility Loci ◽  
Autoimmune Thyroid ◽  
Affected Sib Pair

scholarly journals Advances in Research on the Role of Chemokines in Occurrence and Development of Autoimmune Thyroid Disease

2015 ◽  
Vol 4 (3) ◽  
pp. 59-63
Author(s):  
Guang Ji
Keyword(s):  
Thyroid Disease ◽  
Hashimoto’S Thyroiditis ◽  
Autoimmune Thyroid Disease ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Neutrophil Chemotaxis ◽  
Autoimmune Thyroid

AbstractChemokines can be divided into four categories: α, β, γ, and δ. Chemokine α is related to neutrophil chemotaxis. Chemokine β is correlated with adsorption of monocytes, basophils, and eosinophils. Chemokine γ is mainly a lymphocyte chemokine. Function of chemokine δ remains unclear. Chemokines α and β are primarily related to occurrence and development of autoimmune thyroid disease. This study reviews chemokines and their receptors that are related to Graves’ disease and Hashimoto’s thyroiditis.

scholarly journals No association of two Fas gene polymorphisms with Hashimoto's thyroiditis and Graves' disease

2003 ◽  
pp. 393-396 ◽  
Author(s):  
BJ Stuck ◽  
MA Pani ◽  
F Besrour ◽  
M Segni ◽  
M Krause ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Genetic Risk ◽  
Hashimoto’S Thyroiditis ◽  
Gene Polymorphisms ◽  
Autoimmune Thyroid Disease ◽  
Fas Ligand ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Autoimmune Thyroid ◽  
Hla Dq

BACKGROUND: Apoptosis is a joint pathogenic process underlying autoimmune thyroid disease. Increased programmed cell death in thyrocytes causes hypothyroidism in Hashimoto's thyroiditis, whereas in Graves' disease infiltrating lymphocytes undergo apoptosis while thyrocytes appear to proliferate under protection of anti-apoptotic signals. The Fas/Fas ligand cascade represents a major pathway initiating apoptosis. Its role in autoimmunity is well studied and genetic polymorphisms in gene loci of Fas and its ligand have been shown to be associated with autoimmune diseases. OBJECTIVE: Due to the functional relevance of the Fas pathway in autoimmune thyroid disease we were interested in the possible contribution of polymorphisms in the Fas gene to the genetic risk of thyroid autoimmunity, which so far is mainly, but incompletely, attributed to the HLA DQ region and polymorphisms in the CTLA-4 gene. DESIGN: We genotyped Caucasian families with at least one offspring affected by Hashimoto's thyroiditis (n=95) and Graves' disease (n=109) for two Fas gene polymorphisms (g-670 G-->A in the promoter region, g-154 C-->T in exon 7). METHODS: Extended transmission disequilibrium and chi(2) testing were performed. RESULTS: Neither polymorphism alone (P=0.44 and P=0.70) nor the promoter/exon 7 haplotypes (P=0.86) were associated with Hashimoto's thyroiditis. No association with Graves' disease was observed for the promoter polymorphism (P=0.91) and exon 7 (P=0.65) or the promoter/exon 7 haplotypes (P=0.80). CONCLUSION: In summary, our data do not suggest any significant contribution of common genetic Fas variants to the genetic risk of developing Hashimoto's thyroiditis or Graves' disease.

scholarly journals The different approaches to the genetic analysis of autoimmune thyroid disease

1999 ◽  
Vol 163 (1) ◽  
pp. 7-13 ◽  
Author(s):  
A Allahabadia ◽  
SC Gough
Keyword(s):  
Linkage Disequilibrium ◽  
Linkage Analysis ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Case Control ◽  
Graves Disease ◽  
Susceptibility Loci ◽  
Case Control Studies ◽  
Autoimmune Thyroid ◽  
Genome Screening

Graves' disease and Hashimoto's thyroiditis are organ-specific autoimmune disorders of multifactorial aetiology with a polygenic mode of inheritance. Familial clustering and twin studies provide evidence for a genetic predisposition. Three main approaches have been used in the search for susceptibility loci: population-based case-control studies, classical linkage analysis, and intrafamilial linkage disequilibrium. Case-control studies are a sensitive method of gene detection and the collection of subjects is resource-efficient. However, they require prior knowledge of a candidate gene and are prone to inconsistent results due to false positives that may arise from population mismatch. Linkage analysis is a powerful tool for detecting 'major' genes that does not require a candidate gene and is, therefore, a means of genome screening. This method, however, has limited power to detect genes of 'modest' effect, and the collection of sibpairs and multiple family members may be difficult. Intrafamilial linkage disequilibrium analysis is more sensitive than classical linkage analysis, requires only one affected offspring, and eliminates population mismatch. This approach has confirmed linkage disequilibrium of the HLA region with Graves' disease, previously not detected by linkage analysis. Knowledge of a candidate locus is required, however, and this method cannot, therefore, at present be used for genome screening. It is likely that a combination of all three approaches will be required to identify susceptibility loci for autoimmune thyroid disease.

scholarly journals Screening of celiac disease in patients with autoimmune thyroid disease from Southern Brazil

2014 ◽  
Vol 58 (6) ◽  
pp. 625-629 ◽  
Author(s):  
Laila M. Teixeira ◽  
Renato Nisihara ◽  
Shirley Ramos da Rosa Utiyama ◽  
Ricardo S. de Bem ◽  
Cristina Marcatto ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Thyroid Disease ◽  
Hashimoto’S Thyroiditis ◽  
Autoimmune Thyroid Disease ◽  
Gastrointestinal Symptoms ◽  
University Hospital ◽  
Hashimoto's Thyroiditis ◽  
Upper Gastrointestinal Endoscopy ◽  
Southern Brazil ◽  
Autoimmune Thyroid

Objective: The objective of this study was to determine the prevalence of celiac disease (CD) in adults with autoimmune thyroid disease (ATD) from the endocrinology outpatient setting in a university hospital in Southern Brazil. Subjects and methods: From the years 2007 to 2011, 254 patients with ATD were enrolled consecutively, Grave’s disease was diagnosed in 143 (56.3%) and Hashimoto’s thyroiditis in 111 (43.7%) of them. All patients answered a questionnaire related to symptoms that could be associated with CD and serum samples to screen for IgA anti-endomysial (EmA-IgA) were collected. EmA-IgA-positive patients were offered upper gastrointestinal endoscopy and biopsy of duodenum. Results: A total of 254 patients were included; 222 (87.4%) female, mean age 45.4 ± 13.43 years (18 to 79 years). EmA-IgA was positive in seven patients (2.7%) and five done endoscopy with biopsy. Of these, three diagnosis of CD was confirmed (1.2%). All the three patients with CD had higher EmA-IgA titration, were female and had Hashimoto’s thyroiditis. Like other patients with ATD, CD patients had nonspecific gastrointestinal symptoms, such as heartburn and gastric distention. In our study, one in each 85 patients confirmed the diagnosis of CD. Conclusion: We found a prevalence of 1.2% (1:85) of confirmed CD among Brazilian patients with ATD. Although some IgA-EmA positive patients had Graves’ disease and one was male, all three patients with confirmed CD were female and had Hashimoto’s thyroiditis. Arq Bras Endocrinol Metab. 2014;58(6):625-9

Genome wide linkage scan for autoimmune thyroid disease susceptibility loci in multiplex Tunisian family.

2019 ◽  
Author(s):  
Ghazi Chabchoub ◽  
Wajdi Sefi ◽  
Abdellatif Maalej ◽  
Faten Hadj Kacem ◽  
Mouna Mnif ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Disease Susceptibility ◽  
Susceptibility Loci ◽  
Autoimmune Thyroid ◽  
Genome Wide ◽  
Tunisian Family

scholarly journals ‘Linkage Analysis of Thyroid Antibody Production: Evidence for Shared Susceptibility to Clinical Autoimmune Thyroid Disease

2008 ◽  
Vol 93 (9) ◽  
pp. 3589-3596 ◽  
Author(s):  
Yoshiyuki Ban ◽  
David A. Greenberg ◽  
Terry F. Davies ◽  
Eric Jacobson ◽  
Erlinda Concepcion ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Antibody Production ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Antibody ◽  
Autoimmune Thyroid
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