scholarly journals Corrigendum to: Cohort Profile: The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry)

2021 ◽  
Author(s):  
Margaret Gatz ◽  
Jennifer R Harris ◽  
Jaakko Kaprio ◽  
Matt McGue ◽  
Nicholas L Smith ◽  
...  
Keyword(s):  
Research Council ◽  
National Research Council ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Academy Of Sciences

scholarly journals Genetic and Environmental Influences on Blood Pressure and Body Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry

Hypertension ◽  
2020 ◽  
Vol 76 (5) ◽  
pp. 1428-1434
Author(s):  
Bin Wang ◽  
Ting Wu ◽  
Michael C. Neale ◽  
Renske Verweij ◽  
Gaifen Liu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
World War Ii ◽  
Research Council ◽  
National Research Council ◽  
World War ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
World War Ii Veteran ◽  
Academy Of Sciences

Blood pressure (BP) and obesity phenotypes may covary due to shared genetic or environmental factors or both. Furthermore, it is possible that the heritability of BP differs according to obesity status—a form of G×E interaction. This hypothesis has never been tested in White twins. The present study included 15 924 White male twin pairs aged between 15 and 33 years from the National Academy of Sciences–National Research Council World War II Veteran Twin Registry. Systolic and diastolic BPs, as well as height and weight, were measured at the induction physical examination. Body mass index (BMI) was used as the index of general obesity. Quantitative genetic modeling was performed using Mx software. Univariate analysis showed that narrow sense heritabilities (95% CI) for systolic BP, diastolic BP, height, and BMI were 0.401 (0.381–0.420), 0.297 (0.280–0.320), 0.866 (0.836–0.897), and 0.639 (0.614–0.664), respectively. Positive phenotypic correlations of BMI with systolic BP (r=0.13) and diastolic BP (r=0.08) were largely due to genetic factors (70% and 86%, respectively). The gene-BMI interaction analysis did not show any support for a modifying effect of BMI on genetic and environmental influences of systolic BP and diastolic BP. Our results suggest that correlations between BP and BMI are mainly explained by common genes influencing both. Higher BMI levels have no influence on the penetrance of genetic vulnerability to elevated BP. These conclusions may prove valuable for gene-finding studies.

The National Academy of Sciences – National Research Council Veteran Twin Registry

1994 ◽  
Vol 43 (1-2) ◽  
pp. 89-94 ◽  
Author(s):  
M.M. Braun ◽  
R. Haupt ◽  
N.E. Caporaso
Keyword(s):  
Molecular Biology ◽  
Research Council ◽  
National Research Council ◽  
Twin Data ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Recent Advances ◽  
History Of ◽  
The Creation ◽  
Academy Of Sciences

With recent advances in molecular biology and genetics, cohorts such as the National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry may become of increasing importance. This paper outlines the creation and history of the NAS-NRC Twin Registry, methodologies utilized for analysis of twin data, studies that have been completed or are underway, and possible future types of studies.

scholarly journals Cohort Profile: The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry)

2014 ◽  
Vol 44 (3) ◽  
pp. 819-825 ◽  
Author(s):  
Margaret Gatz ◽  
Jennifer R Harris ◽  
Jaakko Kaprio ◽  
Matt McGue ◽  
Nicholas L Smith ◽  
...  
Keyword(s):  
Research Council ◽  
National Research Council ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Academy Of Sciences

The Season of Birth of Schizophrenic, Neurotic and Psychiatrically Normal Twins

1982 ◽  
Vol 141 (2) ◽  
pp. 186-190 ◽  
Author(s):  
Kenneth S. Kendler
Keyword(s):  
Research Council ◽  
National Research Council ◽  
Twin Studies ◽  
Season Of Birth ◽  
Perinatal Complications ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Increased Risk ◽  
Academy Of Sciences ◽  
Normal Twin

SummaryThe quarter of birth of 536 schizophrenic, 1,991 neurotic and 12,085 psychiatrically normal twin pairs from the National Academy of Sciences-National Research Council Twin Registry was compared. When either all twin pairs, or only monozygotic or dizygotic twin pairs, were considered, no significant differences were found in the quarter of birth between the 3 groups. No difference in quarter of birth was found for twin pairs concordant versus discordant for schizophrenia. Despite the increased risk for intrauterine and perinatal complications in twin births, schizophrenic twins appear (at least) to be no more vulnerable than schizophrenic singletons to the seasonal gestation and birth-related insults which probably underlie the seasonality in schizophrenic births. Controlling for season of birth probably has little effect on the results of twin studies of schizophrenia.

Month of Birth by Zygosity in the NAS-NRC Twin Registry

1983 ◽  
Vol 32 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Kenneth S. Kendler ◽  
C. Dennis Robinette
Keyword(s):  
United States ◽  
Research Council ◽  
National Research Council ◽  
The United States ◽  
Month Of Birth ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Unselected Group ◽  
Academy Of Sciences ◽  
Seasonality Of Birth

Previous results regarding a seasonality of twin births have been conflicting. Since the biology of monozygotic (MZ) twinning differs from that of dizygotic (DZ) twinning, it is possible that the seasonality of birth for these two twin types might differ. However, all previous studies examining the seasonality of birth by zygosity has estimated zygosity by Weinberg's method. In this report, the month of birth of all MZ and DZ veteran twins from the United States National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry are compared with that found for an unselected group of veterans. Zygosity in the registry has been individually assigned to all twin pairs by a well-validated method. Compared to unselected veterans, the distribution of births by months did not differ significantly for all the veteran twin pairs or for the MZ and DZ twin pairs considered separately. The distribution of month of birth of the MZ and DZ twin pairs did not differ significantly from one another. These results are not consistent with a significant seasonality of MZ, DZ, or all twin births in the United States.

scholarly journals The NAS-NRC Twin Registry and Duke Twins Study of Memory in Aging: An Update

2019 ◽  
Vol 22 (6) ◽  
pp. 757-760 ◽  
Author(s):  
Margaret Gatz ◽  
Brenda L. Plassman ◽  
Caroline M. Tanner ◽  
Samuel M. Goldman ◽  
Gary E. Swan ◽  
...  
Keyword(s):  
World War Ii ◽  
Human Genetics ◽  
White Male ◽  
National Research Council ◽  
Armed Forces ◽  
National Archive ◽  
Population Based ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Academy Of Sciences

AbstractThe National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry is one of the oldest, national population-based twin registries in the USA. It comprises 15,924 White male twin pairs born in the years 1917–1927 (N = 31.848), both of whom served in the armed forces, chiefly during World War II. This article updates activities in this registry since the most recent report in Twin Research and Human Genetics (Page, 2006). Records-based data include information from enlistment charts and Veterans Administration data linkages. There have been three major epidemiologic questionnaires and an education and earnings survey. Separate data collection efforts with the NAS-NRC registry include the National Heart, Lung, and Blood Institute (NHLBI) subsample, the Duke Twins Study of Memory in Aging and a clinically based study of Parkinson’s disease. Progress has been made on consolidating the various data holdings of the NAS-NRC Twin Registry. Data that had been available through the National Academy of Sciences are now freely available through National Archive of Computerized Data on Aging (NACDA).

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