scholarly journals Efficacy of Ebola Glycoprotein-Specific Equine Polyclonal Antibody Product Against Lethal Ebola Virus Infection in Guinea Pigs

2018 ◽  
Vol 218 (suppl_5) ◽  
pp. S603-S611 ◽  
Author(s):  
Mable Chan ◽  
Frederick W Holtsberg ◽  
Hong Vu ◽  
Katie A Howell ◽  
Anders Leung ◽  
...  
Keyword(s):  
Virus Infection ◽  
Polyclonal Antibody ◽  
Guinea Pigs ◽  
Ebola Virus ◽  
Ebola Virus Infection

scholarly journals Pathogenesis of Experimental Ebola Virus Infection in Guinea Pigs

1999 ◽  
Vol 179 (s1) ◽  
pp. S203-S217 ◽  
Author(s):  
Brett M. Connolly ◽  
Keith E. Steele ◽  
Kelly J. Davis ◽  
Thomas W. Geisbert ◽  
Wayne M. Kell ◽  
...  
Keyword(s):  
Virus Infection ◽  
Guinea Pigs ◽  
Ebola Virus ◽  
Ebola Virus Infection

Ebola virus infection in guinea pigs: presumable role of granulomatous inflammation in pathogenesis

1996 ◽  
Vol 141 (5) ◽  
pp. 909-921 ◽  
Author(s):  
E. Ryabchikova ◽  
L. Kolesnikova ◽  
M. Smolina ◽  
V. Tkachev ◽  
L. Pereboeva ◽  
...  
Keyword(s):  
Virus Infection ◽  
Guinea Pigs ◽  
Ebola Virus ◽  
Granulomatous Inflammation ◽  
Ebola Virus Infection

scholarly journals Development of a Cost-effective Ovine Polyclonal Antibody-Based Product, EBOTAb, to Treat Ebola Virus Infection

2015 ◽  
Vol 213 (7) ◽  
pp. 1124-1133 ◽  
Author(s):  
Stuart David Dowall ◽  
Jo Callan ◽  
Antra Zeltina ◽  
Ibrahim Al-Abdulla ◽  
Thomas Strecker ◽  
...  
Keyword(s):  
Virus Infection ◽  
Polyclonal Antibody ◽  
Ebola Virus ◽  
Cost Effective ◽  
Ebola Virus Infection

scholarly journals Ebola GP-Specific Monoclonal Antibodies Protect Mice and Guinea Pigs from Lethal Ebola Virus Infection

2012 ◽  
Vol 6 (3) ◽  
pp. e1575 ◽  
Author(s):  
Xiangguo Qiu ◽  
Lisa Fernando ◽  
P. Leno Melito ◽  
Jonathan Audet ◽  
Heinz Feldmann ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
Guinea Pigs ◽  
Ebola Virus ◽  
Ebola Virus Infection

scholarly journals Antibody-Dependent Enhancement of Ebola Virus Infection

2003 ◽  
Vol 77 (13) ◽  
pp. 7539-7544 ◽  
Author(s):  
Ayato Takada ◽  
Heinz Feldmann ◽  
Thomas G. Ksiazek ◽  
Yoshihiro Kawaoka
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Human Populations ◽  
Hemorrhagic Disease ◽  
Viral Infectivity ◽  
Kidney Cells ◽  
Emerging Pathogens ◽  
Viral Glycoprotein ◽  
Antibody Dependent Enhancement ◽  
Ebola Virus Infection

ABSTRACT Most strains of Ebola virus cause a rapidly fatal hemorrhagic disease in humans, yet there are still no biologic explanations that adequately account for the extreme virulence of these emerging pathogens. Here we show that Ebola Zaire virus infection in humans induces antibodies that enhance viral infectivity. Plasma or serum from convalescing patients enhanced the infection of primate kidney cells by the Zaire virus, and this enhancement was mediated by antibodies to the viral glycoprotein and by complement component C1q. Our results suggest a novel mechanism of antibody-dependent enhancement of Ebola virus infection, one that would account for the dire outcome of Ebola outbreaks in human populations.

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