Dual role of antigen-presenting cells during Ebola virus infection

2017 ◽  
Author(s):  
Emily Nelson
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Antigen Presenting Cells ◽  
Dual Role ◽  
Antigen Presenting ◽  
Ebola Virus Infection

scholarly journals Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Anja Lüdtke ◽  
Paula Ruibal ◽  
David M. Wozniak ◽  
Elisa Pallasch ◽  
Stephanie Wurr ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Ebola Virus ◽  
Chimeric Mice ◽  
Virus Dissemination ◽  
Ebola Virus Infection

Ebola virus infection in guinea pigs: presumable role of granulomatous inflammation in pathogenesis

1996 ◽  
Vol 141 (5) ◽  
pp. 909-921 ◽  
Author(s):  
E. Ryabchikova ◽  
L. Kolesnikova ◽  
M. Smolina ◽  
V. Tkachev ◽  
L. Pereboeva ◽  
...  
Keyword(s):  
Virus Infection ◽  
Guinea Pigs ◽  
Ebola Virus ◽  
Granulomatous Inflammation ◽  
Ebola Virus Infection

scholarly journals Antibody-Dependent Enhancement of Ebola Virus Infection

2003 ◽  
Vol 77 (13) ◽  
pp. 7539-7544 ◽  
Author(s):  
Ayato Takada ◽  
Heinz Feldmann ◽  
Thomas G. Ksiazek ◽  
Yoshihiro Kawaoka
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Human Populations ◽  
Hemorrhagic Disease ◽  
Viral Infectivity ◽  
Kidney Cells ◽  
Emerging Pathogens ◽  
Viral Glycoprotein ◽  
Antibody Dependent Enhancement ◽  
Ebola Virus Infection

ABSTRACT Most strains of Ebola virus cause a rapidly fatal hemorrhagic disease in humans, yet there are still no biologic explanations that adequately account for the extreme virulence of these emerging pathogens. Here we show that Ebola Zaire virus infection in humans induces antibodies that enhance viral infectivity. Plasma or serum from convalescing patients enhanced the infection of primate kidney cells by the Zaire virus, and this enhancement was mediated by antibodies to the viral glycoprotein and by complement component C1q. Our results suggest a novel mechanism of antibody-dependent enhancement of Ebola virus infection, one that would account for the dire outcome of Ebola outbreaks in human populations.

scholarly journals Loss of Interleukin 1 Receptor Antagonist Enhances Susceptibility to Ebola Virus Infection

2015 ◽  
Vol 212 (suppl 2) ◽  
pp. S329-S335 ◽  
Author(s):  
Lindsay Hill-Batorski ◽  
Peter Halfmann ◽  
Andrea Marzi ◽  
Tiago J. S. Lopes ◽  
Gabriele Neumann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Receptor Antagonist ◽  
Ebola Virus ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Ebola Virus Infection
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