scholarly journals Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance

2009 ◽  
Vol 21 (4) ◽  
pp. 379-391 ◽  
Author(s):  
Kanji Nagahama ◽  
Zoltan Fehervari ◽  
Takatoku Oida ◽  
Tomoyuki Yamaguchi ◽  
Osamu Ogawa ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Effector T Cells ◽  
Transplantation Tolerance ◽  
Differential Control

scholarly journals Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance

2011 ◽  
Vol 208 (10) ◽  
pp. 2043-2053 ◽  
Author(s):  
Adrian R. Kendal ◽  
Ye Chen ◽  
Frederico S. Regateiro ◽  
Jianbo Ma ◽  
Elizabeth Adams ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Tissue Damage ◽  
Paradigm Shift ◽  
Effector T Cells ◽  
Transplantation Tolerance ◽  
Self Tolerance ◽  
Infectious Tolerance ◽  
First Time

A paradigm shift in immunology has been the recent discovery of regulatory T cells (T reg cells), of which CD4+Foxp3+ cells are proven as essential to self-tolerance. Using transgenic B6.Foxp3hCD2 mice to isolate and ablate Foxp3+ T reg cells with an anti-hCD2 antibody, we show for the first time that CD4+Foxp3+ cells are crucial for infectious tolerance induced by nonablative anti–T cell antibodies. In tolerant animals, Foxp3+ T reg cells are constantly required to suppress effector T cells still capable of causing tissue damage. Tolerated tissue contains T cells that are capable of rejecting it, but are prevented from doing so by therapeutically induced Foxp3+ T reg cells. Finally, Foxp3+ cells have been confirmed as the critical missing link through which infectious tolerance operates in vivo. Peripherally induced Foxp3+ cells sustain tolerance by converting naive T cells into the next generation of Foxp3+ cells. Empowering Foxp3+ regulatory T cells in vivo offers a tractable route to avoid and correct tissue immunopathology.

scholarly journals Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells

2011 ◽  
Vol 41 (3) ◽  
pp. 726-738 ◽  
Author(s):  
Ross S. Francis ◽  
Gang Feng ◽  
Thanyalak Tha-In ◽  
Ian S. Lyons ◽  
Kathryn J. Wood ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Effector T Cells ◽  
Transplantation Tolerance

scholarly journals Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157822 ◽  
Author(s):  
Nicolas Goudin ◽  
Pascal Chappert ◽  
Jérome Mégret ◽  
David-Alexandre Gross ◽  
Benedita Rocha ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Effector T Cells

scholarly journals Favorably Tipping the Balance between Cytopathic and Regulatory T Cells to Create Transplantation Tolerance

Immunity ◽  
2003 ◽  
Vol 19 (4) ◽  
pp. 503-514 ◽  
Author(s):  
Xin Xiao Zheng ◽  
Alberto Sánchez-Fueyo ◽  
Masayuki Sho ◽  
Christoph Domenig ◽  
Mohamed H Sayegh ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transplantation Tolerance
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