scholarly journals A dynamic reaction picklist for improving allergy reaction documentation in the electronic health record

2020 ◽  
Vol 27 (6) ◽  
pp. 917-923
Author(s):  
Liqin Wang ◽  
Suzanne V Blackley ◽  
Kimberly G Blumenthal ◽  
Sharmitha Yerneni ◽  
Foster R Goss ◽  
...  
Keyword(s):  
Electronic Health Record ◽  
Language Processing ◽  
Clinical Decision ◽  
Free Text ◽  
Health Record ◽  
Dynamic Reaction ◽  
Value Set ◽  
Expert Review ◽  
Electronic Health ◽  
Development And Validation

Abstract Objective Incomplete and static reaction picklists in the allergy module led to free-text and missing entries that inhibit the clinical decision support intended to prevent adverse drug reactions. We developed a novel, data-driven, “dynamic” reaction picklist to improve allergy documentation in the electronic health record (EHR). Materials and Methods We split 3 decades of allergy entries in the EHR of a large Massachusetts healthcare system into development and validation datasets. We consolidated duplicate allergens and those with the same ingredients or allergen groups. We created a reaction value set via expert review of a previously developed value set and then applied natural language processing to reconcile reactions from structured and free-text entries. Three association rule-mining measures were used to develop a comprehensive reaction picklist dynamically ranked by allergen. The dynamic picklist was assessed using recall at top k suggested reactions, comparing performance to the static picklist. Results The modified reaction value set contained 490 reaction concepts. Among 4 234 327 allergy entries collected, 7463 unique consolidated allergens and 469 unique reactions were identified. Of the 3 dynamic reaction picklists developed, the 1 with the optimal ranking achieved recalls of 0.632, 0.763, and 0.822 at the top 5, 10, and 15, respectively, significantly outperforming the static reaction picklist ranked by reaction frequency. Conclusion The dynamic reaction picklist developed using EHR data and a statistical measure was superior to the static picklist and suggested proper reactions for allergy documentation. Further studies might evaluate the usability and impact on allergy documentation in the EHR.

Enhancing goals of care communication by oncologists using a pathway-based intervention.

2021 ◽  
Vol 39 (28_suppl) ◽  
pp. 324-324
Author(s):  
Isaac S. Chua ◽  
Elise Tarbi ◽  
Jocelyn H. Siegel ◽  
Kate Sciacca ◽  
Anne Kwok ◽  
...  
Keyword(s):  
Electronic Health Record ◽  
Advanced Cancer ◽  
Language Processing ◽  
Clinical Pathways ◽  
Free Text ◽  
Health Record ◽  
Goals Of Care ◽  
Progress Notes ◽  
Electronic Health ◽  
Pilot Sample

324 Background: Delivering goal-concordant care to patients with advanced cancer requires identifying eligible patients who would benefit from goals of care (GOC) conversations; training clinicians how to have these conversations; conducting conversations in a timely manner; and documenting GOC conversations that can be readily accessed by care teams. We used an existing, locally developed electronic cancer care clinical pathways system to guide oncologists toward these conversations. Methods: To identify eligible patients, pathways directors from 12 oncology disease centers identified therapeutic decision nodes for each pathway that corresponded to a predicted life expectancy of ≤1 year. When oncologists selected one of these pre-identified pathways nodes, the decision was captured in a relational database. From these patients, we sought evidence of GOC documentation within the electronic health record by extracting coded data from the advance care planning (ACP) module—a designated area within the electronic health record for clinicians to document GOC conversations. We also used rule-based natural language processing (NLP) to capture free text GOC documentation within these same patients’ progress notes. A domain expert reviewed all progress notes identified by NLP to confirm the presence of GOC documentation. Results: In a pilot sample obtained between March 20 and September 25, 2020, we identified a total of 21 pathway nodes conveying a poor prognosis, which represented 91 unique patients with advanced cancer. Among these patients, the mean age was 62 (SD 13.8) years old; 55 (60.4%) patients were female, and 69 (75.8%) were non-Hispanic White. The cancers most represented were thoracic (32 [35.2%]), breast (31 [34.1%]), and head and neck (13 [14.3%]). Within the 3 months leading up to the pathways decision date, a total 62 (68.1%) patients had any GOC documentation. Twenty-one (23.1%) patients had documentation in both the ACP module and NLP-identified progress notes; 5 (5.5%) had documentation in the ACP module only; and 36 (39.6%) had documentation in progress notes only. Twenty-two unique clinicians utilized the ACP module, of which 1 (4.5%) was an oncologist and 21 (95.5%) were palliative care clinicians. Conclusions: Approximately two thirds of patients had any GOC documentation. A total of 26 (28.6%) patients had any GOC documentation in the ACP module, and only 1 oncologist documented using the ACP module, where care teams can most easily retrieve GOC information. These findings provide an important baseline for future quality improvement efforts (e.g., implementing serious illness communications training, increasing support around ACP module utilization, and incorporating behavioral nudges) to enhance oncologists’ ability to conduct and to document timely, high quality GOC conversations.

scholarly journals Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data

2019 ◽  
Author(s):  
Daniel M. Bean ◽  
James Teo ◽  
Honghan Wu ◽  
Ricardo Oliveira ◽  
Raj Patel ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Natural Language Processing ◽  
Natural Language ◽  
Electronic Health Record ◽  
Open Source ◽  
Language Processing ◽  
Risk Scores ◽  
Free Text ◽  
Health Record ◽  
Electronic Health

AbstractAtrial fibrillation (AF) is the most common arrhythmia and significantly increases stroke risk. This risk is effectively managed by oral anticoagulation. Recent studies using national registry data indicate increased use of anticoagulation resulting from changes in guidelines and the availability of newer drugs.The aim of this study is to develop and validate an open source risk scoring pipeline for free-text electronic health record data using natural language processing.AF patients discharged from 1st January 2011 to 1st October 2017 were identified from discharge summaries (N=10,030, 64.6% male, average age 75.3 ± 12.3 years). A natural language processing pipeline was developed to identify risk factors in clinical text and calculate risk for ischaemic stroke (CHA2DS2-VASc) and bleeding (HAS-BLED). Scores were validated vs two independent experts for 40 patients.Automatic risk scores were in strong agreement with the two independent experts for CHA2DS2-VASc (average kappa 0.78 vs experts, compared to 0.85 between experts). Agreement was lower for HAS-BLED (average kappa 0.54 vs experts, compared to 0.74 between experts).In high-risk patients (CHA2DS2-VASc ≥2) OAC use has increased significantly over the last 7 years, driven by the availability of DOACs and the transitioning of patients from AP medication alone to OAC. Factors independently associated with OAC use included components of the CHA2DS2-VASc and HAS-BLED scores as well as discharging specialty and frailty. OAC use was highest in patients discharged under cardiology (69%).Electronic health record text can be used for automatic calculation of clinical risk scores at scale. Open source tools are available today for this task but require further validation. Analysis of routinely-collected EHR data can replicate findings from large-scale curated registries.

scholarly journals “Big Data” and the Electronic Health Record

2014 ◽  
Vol 23 (01) ◽  
pp. 97-104 ◽  
Author(s):  
M. K. Ross ◽  
Wei Wei ◽  
L. Ohno-Machado
Keyword(s):  
Big Data ◽  
Electronic Health Record ◽  
Language Processing ◽  
Clinical Data ◽  
Improve Patient Care ◽  
Clinical Decision ◽  
Health Record ◽  
Privacy And Security ◽  
Pubmed Database ◽  
Electronic Health

Summary Objectives: Implementation of Electronic Health Record (EHR) systems continues to expand. The massive number of patient encounters results in high amounts of stored data. Transforming clinical data into knowledge to improve patient care has been the goal of biomedical informatics professionals for many decades, and this work is now increasingly recognized outside our field. In reviewing the literature for the past three years, we focus on “big data” in the context of EHR systems and we report on some examples of how secondary use of data has been put into practice. Methods: We searched PubMed database for articles from January 1, 2011 to November 1, 2013. We initiated the search with keywords related to “big data” and EHR. We identified relevant articles and additional keywords from the retrieved articles were added. Based on the new keywords, more articles were retrieved and we manually narrowed down the set utilizing predefined inclusion and exclusion criteria. Results: Our final review includes articles categorized into the themes of data mining (pharmacovigilance, phenotyping, natural language processing), data application and integration (clinical decision support, personal monitoring, social media), and privacy and security. Conclusion: The increasing adoption of EHR systems worldwide makes it possible to capture large amounts of clinical data. There is an increasing number of articles addressing the theme of “big data”, and the concepts associated with these articles vary. The next step is to transform healthcare big data into actionable knowledge.

scholarly journals Dissemination of child abuse clinical decision support: Moving beyond a single electronic health record

2021 ◽  
Vol 147 ◽  
pp. 104349
Author(s):  
Thomas McGinn ◽  
David A. Feldstein ◽  
Isabel Barata ◽  
Emily Heineman ◽  
Joshua Ross ◽  
...  
Keyword(s):  
Child Abuse ◽  
Decision Support ◽  
Electronic Health Record ◽  
Clinical Decision Support ◽  
Clinical Decision ◽  
Health Record ◽  
Electronic Health

scholarly journals HAI-Proactive: Development of an Automated Surveillance System for Healthcare-Associated Infections in Sweden

2020 ◽  
Vol 41 (S1) ◽  
pp. s39-s39
Author(s):  
Pontus Naucler ◽  
Suzanne D. van der Werff ◽  
John Valik ◽  
Logan Ward ◽  
Anders Ternhag ◽  
...  
Keyword(s):  
Positive Predictive Value ◽  
Electronic Health Record ◽  
Predictive Value ◽  
Surveillance System ◽  
Free Text ◽  
Health Record ◽  
Electronic Health Record Data ◽  
Record Data ◽  
Electronic Health ◽  
Healthcare Associated

Background: Healthcare-associated infection (HAI) surveillance is essential for most infection prevention programs and continuous epidemiological data can be used to inform healthcare personal, allocate resources, and evaluate interventions to prevent HAIs. Many HAI surveillance systems today are based on time-consuming and resource-intensive manual reviews of patient records. The objective of HAI-proactive, a Swedish triple-helix innovation project, is to develop and implement a fully automated HAI surveillance system based on electronic health record data. Furthermore, the project aims to develop machine-learning–based screening algorithms for early prediction of HAI at the individual patient level. Methods: The project is performed with support from Sweden’s Innovation Agency in collaboration among academic, health, and industry partners. Development of rule-based and machine-learning algorithms is performed within a research database, which consists of all electronic health record data from patients admitted to the Karolinska University Hospital. Natural language processing is used for processing free-text medical notes. To validate algorithm performance, manual annotation was performed based on international HAI definitions from the European Center for Disease Prevention and Control, Centers for Disease Control and Prevention, and Sepsis-3 criteria. Currently, the project is building a platform for real-time data access to implement the algorithms within Region Stockholm. Results: The project has developed a rule-based surveillance algorithm for sepsis that continuously monitors patients admitted to the hospital, with a sensitivity of 0.89 (95% CI, 0.85–0.93), a specificity of 0.99 (0.98–0.99), a positive predictive value of 0.88 (0.83–0.93), and a negative predictive value of 0.99 (0.98–0.99). The healthcare-associated urinary tract infection surveillance algorithm, which is based on free-text analysis and negations to define symptoms, had a sensitivity of 0.73 (0.66–0.80) and a positive predictive value of 0.68 (0.61–0.75). The sensitivity and positive predictive value of an algorithm based on significant bacterial growth in urine culture only was 0.99 (0.97–1.00) and 0.39 (0.34–0.44), respectively. The surveillance system detected differences in incidences between hospital wards and over time. Development of surveillance algorithms for pneumonia, catheter-related infections and Clostridioides difficile infections, as well as machine-learning–based models for early prediction, is ongoing. We intend to present results from all algorithms. Conclusions: With access to electronic health record data, we have shown that it is feasible to develop a fully automated HAI surveillance system based on algorithms using both structured data and free text for the main healthcare-associated infections.Funding: Sweden’s Innovation Agency and Stockholm County CouncilDisclosures: None

scholarly journals Developing Clinical Decision Support within a Commercial Electronic Health Record System to Improve Antimicrobial Prescribing in the Neonatal ICU

2014 ◽  
Vol 05 (02) ◽  
pp. 368-387 ◽  
Author(s):  
K. Cato ◽  
B. Sheehan ◽  
S. Patel ◽  
J. Duchon ◽  
P. DeLaMora ◽  
...  
Keyword(s):  
Decision Support ◽  
Electronic Health Record ◽  
Clinical Decision Support ◽  
Clinical Decision ◽  
Electronic Health Record System ◽  
Health Record ◽  
Record System ◽  
Antimicrobial Prescribing ◽  
Neonatal Icu ◽  
Electronic Health

SummaryObjective: To develop and implement a clinical decision support (CDS) tool to improve antibiotic prescribing in neonatal intensive care units (NICUs) and to evaluate user acceptance of the CDS tool.Methods: Following sociotechnical analysis of NICU prescribing processes, a CDS tool for empiric and targeted antimicrobial therapy for healthcare-associated infections (HAIs) was developed and incorporated into a commercial electronic health record (EHR) in two NICUs. User logs were reviewed and NICU prescribers were surveyed for their perceptions of the CDS tool.Results: The CDS tool aggregated selected laboratory results, including culture results, to make treatment recommendations for common clinical scenarios. From July 2010 to May 2012, 1,303 CDS activations for 452 patients occurred representing 22% of patients prescribed antibiotics during this period. While NICU clinicians viewed two culture results per tool activation, prescribing recommendations were viewed during only 15% of activations. Most (63%) survey respondents were aware of the CDS tool, but fewer (37%) used it during their most recent NICU rotation. Respondents considered the most useful features to be summarized culture results (43%) and antibiotic recommendations (48%).Discussion: During the study period, the CDS tool functionality was hindered by EHR upgrades, implementation of a new laboratory information system, and changes to antimicrobial testing methodologies. Loss of functionality may have reduced viewing antibiotic recommendations. In contrast, viewing culture results was frequently performed, likely because this feature was perceived as useful and functionality was preserved.Conclusion: To improve CDS tool visibility and usefulness, we recommend early user and information technology team involvement which would facilitate use and mitigate implementation challenges.Citation: Hum RS, Cato K, Sheehan B, Patel S, Duchon J, DeLaMora P, Ferng YH, Graham P, Vawdrey DK, Perlman J, Larson E, Saiman L. Developing clinical decision support within a commercial electronic health record system to improve antimicrobial prescribing in the neonatal ICU. Appl Clin Inf 2014; 5: 368–387 http://dx.doi.org/10.4338/ACI-2013-09-RA-0069

DEVELOPMENT AND VALIDATION OF THE ELECTRONIC HEALTH RECORD RISK OF ALZHEIMER’S AND DEMENTIA ASSESSMENT RULE (ERADAR)

2019 ◽  
Vol 15 (7) ◽  
pp. P225
Author(s):  
Deborah E. Barnes ◽  
Jing Zhou ◽  
Rod L. Walker ◽  
Eric B. Larson ◽  
Sei J. Lee ◽  
...  
Keyword(s):  
Electronic Health Record ◽  
Health Record ◽  
Electronic Health ◽  
Development And Validation

scholarly journals Integrating pharmacogenetic information and clinical decision support into the electronic health record

2014 ◽  
Vol 21 (3) ◽  
pp. 522-528 ◽  
Author(s):  
Barry R Goldspiel ◽  
Willy A Flegel ◽  
Gary DiPatrizio ◽  
Tristan Sissung ◽  
Sharon D Adams ◽  
...  
Keyword(s):  
Decision Support ◽  
Electronic Health Record ◽  
Clinical Decision Support ◽  
Clinical Decision ◽  
Health Record ◽  
Electronic Health

scholarly journals Clinical decision support alert malfunctions: analysis and empirically derived taxonomy

2017 ◽  
Vol 25 (5) ◽  
pp. 496-506 ◽  
Author(s):  
Adam Wright ◽  
Angela Ai ◽  
Joan Ash ◽  
Jane F Wiesen ◽  
Thu-Trang T Hickman ◽  
...  
Keyword(s):  
Decision Support ◽  
Electronic Health Record ◽  
Medical Informatics ◽  
Clinical Decision Support ◽  
Quantitative Methods ◽  
Clinical Decision ◽  
The United States ◽  
Health Record ◽  
Qualitative And Quantitative Methods ◽  
Electronic Health

Abstract Objective To develop an empirically derived taxonomy of clinical decision support (CDS) alert malfunctions. Materials and Methods We identified CDS alert malfunctions using a mix of qualitative and quantitative methods: (1) site visits with interviews of chief medical informatics officers, CDS developers, clinical leaders, and CDS end users; (2) surveys of chief medical informatics officers; (3) analysis of CDS firing rates; and (4) analysis of CDS overrides. We used a multi-round, manual, iterative card sort to develop a multi-axial, empirically derived taxonomy of CDS malfunctions. Results We analyzed 68 CDS alert malfunction cases from 14 sites across the United States with diverse electronic health record systems. Four primary axes emerged: the cause of the malfunction, its mode of discovery, when it began, and how it affected rule firing. Build errors, conceptualization errors, and the introduction of new concepts or terms were the most frequent causes. User reports were the predominant mode of discovery. Many malfunctions within our database caused rules to fire for patients for whom they should not have (false positives), but the reverse (false negatives) was also common. Discussion Across organizations and electronic health record systems, similar malfunction patterns recurred. Challenges included updates to code sets and values, software issues at the time of system upgrades, difficulties with migration of CDS content between computing environments, and the challenge of correctly conceptualizing and building CDS. Conclusion CDS alert malfunctions are frequent. The empirically derived taxonomy formalizes the common recurring issues that cause these malfunctions, helping CDS developers anticipate and prevent CDS malfunctions before they occur or detect and resolve them expediently.

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