Influence of Biological Matrix on Chromatographic Behavior and Detection of Selected Acidic, Neutral, and Basic Drugs Examined by Means of a Standardized HPLC-DAD System

1995 ◽  
Vol 19 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Maciej Bogusz ◽  
Manfred Erkens
Keyword(s):  
Chromatographic Behavior ◽  
Basic Drugs ◽  
Biological Matrix ◽  
Neutral And Basic Drugs

Prediction of pKa for Neutral and Basic Drugs Based on Radial Basis Function Neural Networks and the Heuristic Method

2005 ◽  
Vol 22 (9) ◽  
pp. 1454-1460 ◽  
Author(s):  
Feng Luan ◽  
Weiping Ma ◽  
Haixia Zhang ◽  
Xiaoyun Zhang ◽  
Mancang Liu ◽  
...  
Keyword(s):  
Neural Networks ◽  
Radial Basis Function ◽  
Basis Function ◽  
Heuristic Method ◽  
Basic Drugs ◽  
Radial Basis ◽  
Neutral And Basic Drugs

Profile of Sedatives and Tranquilizers in Serum, as Measured by Gas-Liquid Chromatography

1971 ◽  
Vol 17 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Henning F Proelss ◽  
Herman J Lohmann
Keyword(s):  
Liquid Chromatography ◽  
Solvent Extraction ◽  
Liquid Phase ◽  
Screening Method ◽  
Gas Liquid Chromatography ◽  
Basic Drugs ◽  
Ph Values ◽  
Preliminary Separation ◽  
Glass Columns ◽  
Neutral And Basic Drugs

Abstract We describe here a rapid and comprehensive screening method for 40 commonly used sedatives and tranquilizers with use of gas-liquid chromatography. Barbiturates, nonbarbiturate sedatives, and tranquilizers of the phenothiazine, benzodiazepine, and dibenzazepine type can be both identified and measured in serum. A simple solvent extraction at different pH values, with subsequent solvent partition, effects a preliminary separation into acid, neutral, and basic drugs. The three fractions are separated on two standard 180-cm glass columns: acid and neutral drugs with the liquid phase XE-60 (3.5%) and basic drugs with the liquid phase OV-17(3%). Sera from more than 50 patients have been analyzed by this technique, and the concentrations of several sedatives and tranquilizers are reported.

Contribution to the standardization of the chromatographic conditions for the lipophilicity assessment of neutral and basic drugs

2006 ◽  
Vol 573-574 ◽  
pp. 311-318 ◽  
Author(s):  
Costas Giaginis ◽  
Stamatios Theocharis ◽  
Anna Tsantili-Kakoulidou
Keyword(s):  
Basic Drugs ◽  
Neutral And Basic Drugs
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