A Cautionary Tale of Criteria Based on Anecdotal Evidence with Etanercept in Toxic Epidermal Necrolysis

Author(s):  
Tessa LeWitt ◽  
Kayla St. Claire ◽  
Steven Daveluy
Author(s):  
Janie Faris ◽  
Jordan Wilson ◽  
Heather S Dolman ◽  
Andrew Isaacson ◽  
Alfred E Baylor ◽  
...  

Abstract Toxic epidermal necrolysis (TEN) is a severe cutaneous reaction that can be life-threatening. In the United States, there are no established guidelines for the treatment of TEN. Supportive care including fluids and supportive therapies are the current recommendations. Research surrounding TEN involves mostly case studies or small, uncontrolled studies. Recent literature describes the use of tumor necrosis factor blockers in the treatment of TEN with positive results. These case reports describe decreased time to reepithelization, hospital length of stay, and minimal side effects. Conversely, we present three fatalities after the administration of etanercept.


1975 ◽  
Vol 111 (8) ◽  
pp. 1073b-1073
Author(s):  
J. E. Rasmussen

1974 ◽  
Vol 110 (1) ◽  
pp. 103-104 ◽  
Author(s):  
G. F. Radimer

1976 ◽  
Vol 112 (12) ◽  
pp. 1757-1760 ◽  
Author(s):  
H. M. Robinson

1965 ◽  
Vol 116 (4) ◽  
pp. 515-517 ◽  
Author(s):  
S. Minekowitz

2007 ◽  
Vol 12 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Marisa L. Beeble ◽  
Deborah Bybee ◽  
Cris M. Sullivan

While research has found that millions of children in the United States are exposed to their mothers being battered, and that many are themselves abused as well, little is known about the ways in which children are used by abusers to manipulate or harm their mothers. Anecdotal evidence suggests that perpetrators use children in a variety of ways to control and harm women; however, no studies to date have empirically examined the extent of this occurring. Therefore, the current study examined the extent to which survivors of abuse experienced this, as well as the conditions under which it occurred. Interviews were conducted with 156 women who had experienced recent intimate partner violence. Each of these women had at least one child between the ages of 5 and 12. Most women (88%) reported that their assailants had used their children against them in varying ways. Multiple variables were found to be related to this occurring, including the relationship between the assailant and the children, the extent of physical and emotional abuse used by the abuser against the woman, and the assailant's court-ordered visitation status. Findings point toward the complex situational conditions by which assailants use the children of their partners or ex-partners to continue the abuse, and the need for a great deal more research in this area.


2003 ◽  
Author(s):  
Gerard J. Solan ◽  
Jean M. Casey

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