Whole-body Retention, Tissue Distribution and Excretion of Selenium-75 after Oral and Intravenous Administration in Lambs Fed Varying Selenium Intakes

1969 ◽  
Vol 97 (1) ◽  
pp. 123-132 ◽  
Author(s):  
Perla L. Lopez ◽  
R. L. Preston ◽  
W. H. Pfander
Keyword(s):  
Tissue Distribution ◽  
Intravenous Administration ◽  
Whole Body ◽  
Body Retention ◽  
Selenium 75

scholarly journals Whole-body Retention and Tissue Distribution of Cesium-134 in New-born, Young and Adult Rats

1967 ◽  
Vol 8 (3-4) ◽  
pp. 132-140 ◽  
Author(s):  
Jiro INABA ◽  
Naonori MATSUSAKA ◽  
Ryushi ICHIKAWA
Keyword(s):  
Tissue Distribution ◽  
Whole Body ◽  
Adult Rats ◽  
New Born ◽  
Body Retention

scholarly journals Metabolic studies of [75Se]selenocystine and [75Se]selenomethionine in the rat

1975 ◽  
Vol 34 (3) ◽  
pp. 501-509 ◽  
Author(s):  
Christine D. Thomson ◽  
Bridget A. Robinson ◽  
R. D. H. Stewart ◽  
Marion F. Robinson
Keyword(s):  
Oral Dose ◽  
Urinary Excretion ◽  
Tissue Distribution ◽  
Similar Rate ◽  
Whole Body ◽  
Rabbit Kidney ◽  
Body Retention ◽  
Metabolic Pool

1. The long-term fate in rats of an oral dose of [75Se]selenocystine was compared with that of an oral dose of [75Se]selenomethionine.2. Urinary and faecal radioactivities were measured during the 1st week and whole-body radioactivity was determined for 10 weeks. Rats were killed at weekly intervals for 4 weeks and at weeks 6 and 10 for analysis of tissue distribution of 75Se.3. Intestinal absorption of [75Se]selenocystine was 81% of the administered dose; that of [75Se]selenomethionine was 86%. Urinary excretion of absorbed [75Se]selenocystine was 13.9% and that of [75Se]selenomethionine was 5.8%, in the 1st week.4. Whole-body retention of 75Se was greater for [75Se]selenomethionine than for [75Se]-selenocystine but after the 1st week it decreased at a similar rate in both groups. Tissue distribution of retained 75Se was also similar in both groups.5. The initial utilization of [75Se]selenocystine was different from that of [75Se]selenomethionine. However, after the 1st week 75Se from both sources appeared to be metabolized similarly, suggesting that dietary Se of both forms is ultimately incorporated into the same metabolic pool.6. When these findings were compared with those of earlier studies with [75Se]selenite and 75Se incorporated in vivo into rabbit kidney (RK-75Se) (Thomson, Stewart & Robinson, 1975) the metabolism of [75Se]selenocystine resembled that of [75Se]selenite and RK-75Se, rather than that of [75Se]selenomethionine.

The whole body retention and tissue distribution of [203Hg]methylmercury in adult cats

1975 ◽  
Vol 33 (3) ◽  
pp. 438-449 ◽  
Author(s):  
J.G. Hollins ◽  
R.F. Willes ◽  
F.R. Bryce ◽  
S.M. Charbonneau ◽  
I.C. Munro
Keyword(s):  
Tissue Distribution ◽  
Whole Body ◽  
Body Retention ◽  
Adult Cats

scholarly journals Metabolic studies of [75Se]selenomethionine and [75Se]selenite in the rat

1973 ◽  
Vol 30 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Christine D. Thomson ◽  
R. D. H. Stewart
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Tissue Distribution ◽  
Intestinal Absorption ◽  
Initial Period ◽  
Similar Rate ◽  
Whole Body ◽  
Body Retention ◽  
Metabolic Pool

1. Information was sought concerning the long-term fate of orally and intravenously administered [75Se]selenomethionine and [75Se]selenite in rats.2. Urinary and faecal radioactivity was assayed during the 1st week and whole-body radio-activity was determined weekly for 16 weeks. Rats were killed at intervals for analysis of 75Se tissue distribution.3. Intestinal absorption after oral administration was estimated to be 91–93% for selenite and 95–97% for selenomethionine.4. Urinary excretion of absorbed [75Se]selenite was greater than that of [75Se]selenomethionine during the 1st week.5. After the 1st week, whole-body retention diminished exponentially at a similar rate in rats given either selenomethionine or selenite. Except for the erythrocytes, 75Se content of individual tissues also decreased exponentially.6. It appears that, after an initial period, 75Se from either selenomethionine or selenite is metabolized similarly, suggesting that Se from both potential dietary sources is ultimately incorporated into the same metabolic pool.

scholarly journals Whole Body Retention and Tissue Distribution Studies of 75Se-selenonorcholesterol and Evaluation of Radiation Dose

RADIOISOTOPES ◽  
1979 ◽  
Vol 28 (2) ◽  
pp. 89-91
Author(s):  
Hirofumi MORI ◽  
Ryusuke FUTATSUYA ◽  
Hikaru SETO ◽  
Kiyoshi KOIZUMI ◽  
Atsushi ANDO ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Tissue Distribution ◽  
Whole Body ◽  
Body Retention ◽  
Distribution Studies

The Relationship of 67Ga Uptake to Citrate Dose, Compared with 67Ga-Chloride and 67Ga-Transferrin in Rodent Tissues and Tumours

1980 ◽  
Vol 19 (01) ◽  
pp. 25-28
Author(s):  
Maureen A. Zivanovic ◽  
P. A. G. Hammersley
Keyword(s):  
Tissue Distribution ◽  
Whole Body ◽  
Retention Data ◽  
Tumour Uptake ◽  
Citrate Concentration ◽  
Citrate Complex ◽  
Body Retention ◽  
Injection Dose ◽  
Relationship Of ◽  
The Relationship

The uptake of 67Ga-citrate in the tissues of the mouse and rat and in two mouse tumours, S180 and PC6, has been measured and shown to be independent of the citrate concentration of the injection dose. The tumour uptake and tissue distribution of 67Ga-chloride and 67Ga-transferrin were identical with those of the citrate complex. Whole-body retention data for h7Ga-citrate in the mouse for 14 days after injection are also presented.

Whole-body Retention and Tissue Distribution of 60Co in Rats After Oral Administration of Freshwater Fish Contaminated With 60Co

1982 ◽  
Vol 43 (2) ◽  
pp. 247-250 ◽  
Author(s):  
Jiro Inaba ◽  
Yoshikazu Nishimura ◽  
Ken-Ichi Kimura ◽  
Ryushi Ichikawa
Keyword(s):  
Oral Administration ◽  
Tissue Distribution ◽  
Freshwater Fish ◽  
Whole Body ◽  
Body Retention

scholarly journals Metabolic studies in rats of [75Se]selenomethionine and of 75Se incorporated in vivo into rabbit kidney

1975 ◽  
Vol 33 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Christine D. Thomson ◽  
R. D. H Stewart ◽  
Marion F. Robinson
Keyword(s):  
Oral Dose ◽  
Tissue Distribution ◽  
Similar Rate ◽  
Whole Body ◽  
Rabbit Kidney ◽  
Kidney Homogenate ◽  
Body Retention ◽  
Metabolic Pool

1. [75Se]selenomethionine was administered to four rabbits and after 4 d their kidneys were removed and homogenized. The long-term fate in rats of an oral dose of this kidney homogenate (RK-75Se) was compared with that of an oral dose of [75Se]selenomethionine mixed with unlabelled rabbit kidney homogenate.2. Urinary and faecal radioactivities were measured during the 1st week and whole-body radioactivity was determined for 10 weeks. Rats were killed at weekly intervals for 4 weeks for analysis of tissue distribution of 75Se.3. Intestinal absorption of RK-75Se was 87%; that of [75Se]selenomethionine was 91%. Urinary excretion of absorbed RK-75Se was 13·3% and that of [75Se]selenomethionine was 7·6%, in the 1st week.4. Whole-body retention of 75Se was greater for [75Se]selenomethione than for RK-75Se but after the 1st week decreased at a similar rate in both groups. Tissue distribution of retained 75Se was also similar in both groups.5. The initial utilization of 75Se in rabbit kidney is different from that of [75Se]selenomethionine. However, after the 1st week 75Se from these sources appears to be metabolized similarly, suggesting that Se from both is ultimately incorporated into the same metabolic pool.

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