A novel zinc complex with antibacterial and antioxidant activity

Background In order to enhance the antibacterial activity and reduce the toxicity of Zn2+, novel complexes of Zn(II) were synthesized. Results A water-soluble zinc-glucose-citrate complex (ZnGC) with antibacterial activity was synthesized at pH 6.5. The structure, morphology, characterization, acute toxicity, antibacterial and antioxidant activities, and in situ intestinal absorption were investigated. The results showed that zinc ion was linked with citrate by coordinate bond while the glucose was linked with it through intermolecular hydrogen bonding. The higher the molecular weight of sugar is, the more favorable it is to inhibit the formation of zinc citrate precipitation. Compared with ZnCl2, ZnGC complex presented better antibacterial activity against Staphylococcus aureus (S. aureus, Gram-positive) and Escherichia coli (E. coli, Gram-negative). Conclusions The results of acute toxicity showed no obvious toxicity in this test and in situ intestinal absorption study, suggesting that ZnGC complex could be used as a potential zinc supplement for zinc deficiency.

Influence of the Plant-citrate Complex on Indicators of Systemic Inflammation in Patients with Urolithiasis

Treatment of urolithiasis is a complex task of modern medicine. The search for non-invasive methods of treatment, prevention of relapses and complications, slowing down the development of renal failure is an urgent issue of our time. The study demonstrated a comprehensive analysis of indicators of systemic inflammation in patients with urolithiasis and the effectiveness of using the plant-citrate complex. The objective: to conduct a clinical assessment of systemic inflammation in patients with urolithiasis, to determine the effectiveness of the use of the plant-citrate complex of the drug Uriklar on the indicators of systemic inflammation. Materials and methods. There were examined 52 (55.6 %) patients with urolithiasis, which were divided into two groups: Group I (main group) – 32 patients with urolithiasis who received the herbal citrate complex and Group II (comparison group) – 20 patients with urolithiasis. The control group included 20 almost healthy individuals. All patients underwent clinical and laboratory tests: general and biochemical blood tests to determine the parameters of iron metabolism, lipid profile, CRP, determination of the levels of cytokines in the blood, blood pressure, body mass index. Results. The results of this study demonstrate the development of systemic inflammation in patients with urolithiasis, determined by a decrease in GFR. Against the background of the treatment with Uriklar, a decrease in the levels of pro-inflammatory cytokines, CRP and ferritin is observed, which indicates the anti-inflammatory properties of the drug. Conclusion. Such properties of the plant-citrate complex are pathogenetically substantiated and can be recommended for urolithiasis, which, along with the therapeutic properties, allows to obtain the provision of metaphylaxis of urolithiasis and to slow down the rate of development of chronic kidney disease.

The Influence of the Reaction Conditions on the Size of Silver Nanoparticles in Carey Lea’s Concentrated Sols

The reaction of reduction solution of Ag (I) by Fe (II) citrate complex was studied herein. This allows you to receive silver nanoparticles with high stability with a concentration above 60 g/l. It was determined that the nanoparticles size depends on the injection rate, mixing rate, reagent concentration, pH and some post-synthetic operations on the average size of nanoparticles. It was shown that decreasing the concentration of Ag (I) and increasing the concentration of stabilizer also bringing pH to 7 lead to small and uniform particles. Optimal conditions were found that made it possible to reduce particle size and reduce the concentration of reagents by 33 % in the results. According to XPS, TEM, DLS and FTIR datas, nanoparticles of metallic silver with a size of 6.5±1.8 nm were obtained, which stabilized by the product of partial decay of the citrate ion