Parotid adenocarcinoma metastasis to the breast: a case report

Abstract Metastatic salivary gland tumors are rare clinical entities of the head and neck. Parotid gland carcinoma with distant metastases heralds a poor prognosis with a median survival of 4.3–7.3 months. The lungs, long bones, liver and brain are the most common sites of metastasis for parotid gland cancer, along with a few reported cases describing metastasis to the ileum, spleen and iliac crest. We present the first case to our knowledge of parotid adenocarcinoma metastasis to the breast.

Download Full-text

A Cribriform Cancer Metastatic to Liver: Case Report and Literature Review

Case Reports in Oncology ◽

10.1159/000502572 ◽

2019 ◽

Vol 12 (2) ◽

pp. 681-687 ◽

Cited By ~ 1

Author(s):

Annu Gupta ◽

Padmaja V. Mallidi ◽

Douglas J. Grider

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Past History ◽

Hepatic Metastases ◽

Distant Metastases ◽

First Case ◽

Complete Surgical Resection ◽

History Of ◽

Grade Malignancy ◽

Hepatic Lesions

Metastasis from salivary gland tumors to liver is exceedingly uncommon. Reported is the first case of a mammary analog secretory carcinoma (MASC) of salivary gland origin metastasized to the liver, even after complete surgical resection. A 76 year old female, with past history of a completely extirpated right parotid gland MASC, presented 2 years after right superficial parotidectomy and right neck dissection, with back and flank pain. Subsequent abdominal and pelvic CT revealed multiple small hepatic lesions. Biopsy of the largest hepatic lesion confirmed metastatic MASC of primary parotid gland origin. Both the parotid primary and the hepatic metastases had the confirmatory ETV6 rearrangement by fluorescence in situ hybridization. Although high-grade malignancy and distant metastases of MASC of salivary gland origin to liver is rare, recognizing metastatic MASC potentially alters prognosis and determines therapeutic options.

Download Full-text

Molecularly guided treatment of metastatic parotid gland carcinoma in adults

Wiener klinische Wochenschrift ◽

10.1007/s00508-020-01778-8 ◽

2020 ◽

Author(s):

Hossein Taghizadeh ◽

Leonhard Müllauer ◽

Robert M. Mader ◽

Thorsten Füreder ◽

Gerald W. Prager

Keyword(s):

Targeted Therapy ◽

Parotid Gland ◽

Poor Prognosis ◽

Treatment Approach ◽

Molecular Profiling ◽

Disease Entity ◽

Advanced Therapy ◽

Therapy Recommendation ◽

Gland Carcinoma ◽

Parotid Gland Carcinoma

Summary Background Advanced therapy-refractory parotid gland carcinomas have a poor prognosis with limited therapy options. We used molecular profiling to offer molecular guided therapies to patients with advanced metastatic parotid gland malignancies. Methods In this retrospective analysis we describe the molecular profiling of ten patients diagnosed with therapy-refractory metastatic parotid gland malignancies. Results We identified seven genetic aberrations in five patients: two mutations in CDKN2A and one mutation in APC, ATM, TP53, SMARCB1 and FGFR1, respectively. No mutations were detected in five patients. The IHC demonstrated frequent expressions of EGFR and p‑mTOR, as well as PTEN in eight patients. For four fifths (n = 8) of the patients, a targeted therapy was suggested. Eventually, three patients received the targeted therapy recommendation and one patient achieved stable disease for 14 months. Conclusion A total of eight therapy recommendations were provided. Based on our observations, molecular-guided therapies may be a feasible treatment approach for this rare disease entity.

Download Full-text

Ultrastructure of myoepithelial cell in parotid gland

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100103772 ◽

1988 ◽

Vol 46 ◽

pp. 342-343

Author(s):

C. N. Sun

Keyword(s):

Parotid Gland ◽

Osmium Tetroxide ◽

Individual Cell ◽

Branching Processes ◽

Muscle Cells ◽

Myoepithelial Cells ◽

Uranyl Acetate ◽

Thin Sections ◽

Gland Carcinoma ◽

Parotid Gland Carcinoma

Myoepithelial cells have been observed in the prostate, harderian, apocrine, exocrine sweat and mammary glands. Such cells and their numerous branching processes form basket-like structures around the glandular acini. Their shapes are quite different from structures seen either in spindleshaped smooth muscle cells or skeletal muscle cells. These myoepithelial cells lie on the epithelial side of the basement membrane in the glands. This presentation describes the ultrastructure of such myoepithelial cells which have been found also in the parotid gland carcinoma from a 45-year old patient.Specimens were cut into small pieces about 1 mm3 and immediately fixed in 4 percent glutaraldehyde in phosphate buffer for two hours, then post-fixed in 1 percent buffered osmium tetroxide for 1 hour. After dehydration, tissues were embedded in Epon 812. Thin sections were stained with uranyl acetate and lead citrate. Ultrastructurally, the pattern of each individual cell showed wide variations.

Download Full-text

Pretherapeutic Predictive Factors for Histological High‐Grade Parotid Gland Carcinoma

The Laryngoscope ◽

10.1002/lary.29728 ◽

2021 ◽

Author(s):

Takuya Mikoshiba ◽

Hiroyuki Ozawa ◽

Yoshihiro Watanabe ◽

Miho Kawaida ◽

Mariko Sekimizu ◽

...

Keyword(s):

Parotid Gland ◽

Predictive Factors ◽

High Grade ◽

Gland Carcinoma ◽

Parotid Gland Carcinoma

Download Full-text

54 ORAL Prediction of recurrence in parotid gland carcinoma

European Journal of Surgical Oncology ◽

10.1016/s0748-7983(06)70489-9 ◽

2006 ◽

Vol 32 ◽

pp. S18

Author(s):

J.F. Carrillo ◽

R. Vazquez ◽

F.J. Ochoa-Carrillo ◽

L.F. Oñate-Ocaña ◽

R. Herrera-Goepfert R

Keyword(s):

Parotid Gland ◽

Gland Carcinoma ◽

Parotid Gland Carcinoma

Download Full-text

Occult Primary Parotid Gland Acinic Cell Adenocarcinoma Presenting With Extensive Lung Metastasis

Archives of Pathology & Laboratory Medicine ◽

10.5858/2007-131-970-oppgac ◽

2007 ◽

Vol 131 (6) ◽

pp. 970-973

Author(s):

Fabio Tavora ◽

Negar Rassaei ◽

Konstantin Shilo ◽

Robert D. Foss ◽

Jeffrey R. Galvin ◽

...

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Clinical Evaluation ◽

Distant Metastases ◽

Salivary Gland Neoplasm ◽

Regional Lymph Nodes ◽

Acinic Cell ◽

Parotid Carcinoma ◽

Peripheral Lung ◽

Gland Type

Abstract Acinic cell adenocarcinoma is a malignant salivary gland neoplasm with a relatively low rate of lymphangitic spread to regional lymph nodes. Distant metastases are rare and their occurrence typically indicates an unfavorable outcome. We encountered an unusual example of acinic cell adenocarcinoma that initially presented in the lung, whereas the primary parotid carcinoma, despite extensive clinical evaluation, only became apparent 1 year after initial diagnosis. The histologic, immunohistochemical, and ultrastructural features of the tumor in the parotid gland and lung were similar. The tumor displayed an aggressive behavior resulting in death within 2 years of the initial presentation. This presentation is unique, showing that peripheral lung tumors of salivary gland type are likely to be metastatic, and careful clinical evaluation is warranted in establishing their primary site of origin.

Download Full-text

Signs and symptoms of parotid gland carcinoma and their prognostic value

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.ijom.2011.12.020 ◽

2012 ◽

Vol 41 (7) ◽

pp. 801-806 ◽

Cited By ~ 23

Author(s):

D. Stodulski ◽

B. Mikaszewski ◽

C. Stankiewicz

Keyword(s):

Parotid Gland ◽

Prognostic Value ◽

Signs And Symptoms ◽

Gland Carcinoma ◽

Parotid Gland Carcinoma

Download Full-text

Chronic Paroxysmal Hemicrania as a Manifestation of Intracranial Parotid Gland Carcinoma Metastasis — A Case Report

Cephalalgia ◽

10.1111/j.1468-2982.2003.00606.x ◽

2004 ◽

Vol 24 (3) ◽

pp. 223-227 ◽

Cited By ~ 7

Author(s):

H Mariano da Silva ◽

I Benevides-Luz ◽

AC Santos ◽

CA Bordini ◽

L Campaner ◽

...

Keyword(s):

Case Report ◽

Parotid Gland ◽

Paroxysmal Hemicrania ◽

Chronic Paroxysmal Hemicrania ◽

Gland Carcinoma ◽

Carcinoma Metastasis ◽

Parotid Gland Carcinoma

Download Full-text

Wegener’s granulomatosis mimicking a parotid abscess

The Journal of Laryngology & Otology ◽

10.1258/0022215054797952 ◽

2005 ◽

Vol 119 (9) ◽

pp. 746-749 ◽

Cited By ~ 9

Author(s):

G L Jones ◽

A D Lukaris ◽

H V Prabhu ◽

M J K M Brown ◽

J Bondeson

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Wegener’S Granulomatosis ◽

Wegener's Granulomatosis ◽

Clinical Suspicion ◽

Antineutrophil Cytoplasmic Antibodies ◽

Surgical Exploration ◽

First Case

We present the case of a previously healthy 59-year-old man who was under treatment for scleritis and episcleritis when he developed a parotid-gland swelling and pus-producing sinus. On surgical exploration, the features were those of a parotid abscess, but the lesion not only failed to heal post-operatively but increased in size very significantly. There was also severe necrotizing keratitis of the eyes. Due to clinical suspicion and a positive antineutrophil cytoplasmic antibodies test, Wegener’s granulomatosis was diagnosed and the patient successfully treated with cyclophosphamide and steroids. Previously, a number of cases of Wegener’s granulomatosis causing salivary-gland swelling have been reported in the literature; this is the first case in which the disease has masqueraded as a parotid abscess.

Download Full-text