scholarly journals A Cribriform Cancer Metastatic to Liver: Case Report and Literature Review

2019 ◽  
Vol 12 (2) ◽  
pp. 681-687 ◽  
Author(s):  
Annu Gupta ◽  
Padmaja V. Mallidi ◽  
Douglas J. Grider
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Past History ◽  
Hepatic Metastases ◽  
Distant Metastases ◽  
First Case ◽  
Complete Surgical Resection ◽  
History Of ◽  
Grade Malignancy ◽  
Hepatic Lesions

Metastasis from salivary gland tumors to liver is exceedingly uncommon. Reported is the first case of a mammary analog secretory carcinoma (MASC) of salivary gland origin metastasized to the liver, even after complete surgical resection. A 76 year old female, with past history of a completely extirpated right parotid gland MASC, presented 2 years after right superficial parotidectomy and right neck dissection, with back and flank pain. Subsequent abdominal and pelvic CT revealed multiple small hepatic lesions. Biopsy of the largest hepatic lesion confirmed metastatic MASC of primary parotid gland origin. Both the parotid primary and the hepatic metastases had the confirmatory ETV6 rearrangement by fluorescence in situ hybridization. Although high-grade malignancy and distant metastases of MASC of salivary gland origin to liver is rare, recognizing metastatic MASC potentially alters prognosis and determines therapeutic options.

scholarly journals Parotid adenocarcinoma metastasis to the breast: a case report

2020 ◽  
Vol 2020 (6) ◽  
Author(s):  
Brandon M Smith ◽  
Vitali Azouz ◽  
Louisa Liu ◽  
Gary Williams
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Poor Prognosis ◽  
Iliac Crest ◽  
Distant Metastases ◽  
Long Bones ◽  
Parotid Gland Cancer ◽  
First Case ◽  
Gland Carcinoma ◽  
Parotid Gland Carcinoma

Abstract Metastatic salivary gland tumors are rare clinical entities of the head and neck. Parotid gland carcinoma with distant metastases heralds a poor prognosis with a median survival of 4.3–7.3 months. The lungs, long bones, liver and brain are the most common sites of metastasis for parotid gland cancer, along with a few reported cases describing metastasis to the ileum, spleen and iliac crest. We present the first case to our knowledge of parotid adenocarcinoma metastasis to the breast.

scholarly journals Splenic undifferentiated high grade pleomorphic sarcoma of a small size with fatal tumor rupture

1970 ◽  
Vol 1 (2) ◽  
pp. 151-153 ◽  
Author(s):  
BM Amatya ◽  
M Sawabe ◽  
T Arai ◽  
T Kumakawa ◽  
K Takubo ◽  
...  
Keyword(s):  
Past History ◽  
Distant Metastases ◽  
Tumor Rupture ◽  
Retroperitoneal Hemorrhage ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Bone Marrow Histology ◽  
Pleomorphic Sarcoma ◽  
Fatal Bleeding ◽  
History Of ◽  
The Right

(The order of authors on this article was changed on 09/01/2012.)Primary undifferentiated pleomorphic sarcoma of the spleen is a rare and highly aggressive neoplasm that usually presents with splenomegaly, constitutional symptoms and frequent distant metastases. We report a case of 77-year old male patient with a past history of dissecting aortic aneurysm that developed acute hemorrhagic shock. Aneurysmal rupture was clinically suspected, but the postmortem examination revealed a 25 mm-sized tumor in an atrophic spleen weighing 65 gram with massive retroperitoneal bleeding. Metastases were found in the right renal hilus, the right adrenal gland and femoral bone marrow. Histology of the tumor showed undifferentiated pleomorphic sarcoma. Tumor rupture with fatal bleeding and systemic metastases had occurred despite the small size of the tumor. Tumor size is not a reliable predictor of systemic metastasis or tumor rupture for splenic undifferentiated pleomorphic sarcoma. Keywords: Undifferentiated pleomorphic sarcoma; Malignant fibrous histiocytoma; Splenic neoplasms; Retroperitoneal hemorrhage DOI: http://dx.doi.org/10.3126/jpn.v1i2.5411 JPN 2011; 1(2): 151-153

Occult Primary Parotid Gland Acinic Cell Adenocarcinoma Presenting With Extensive Lung Metastasis

2007 ◽  
Vol 131 (6) ◽  
pp. 970-973
Author(s):  
Fabio Tavora ◽  
Negar Rassaei ◽  
Konstantin Shilo ◽  
Robert D. Foss ◽  
Jeffrey R. Galvin ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Clinical Evaluation ◽  
Distant Metastases ◽  
Salivary Gland Neoplasm ◽  
Regional Lymph Nodes ◽  
Acinic Cell ◽  
Parotid Carcinoma ◽  
Peripheral Lung ◽  
Gland Type

Abstract Acinic cell adenocarcinoma is a malignant salivary gland neoplasm with a relatively low rate of lymphangitic spread to regional lymph nodes. Distant metastases are rare and their occurrence typically indicates an unfavorable outcome. We encountered an unusual example of acinic cell adenocarcinoma that initially presented in the lung, whereas the primary parotid carcinoma, despite extensive clinical evaluation, only became apparent 1 year after initial diagnosis. The histologic, immunohistochemical, and ultrastructural features of the tumor in the parotid gland and lung were similar. The tumor displayed an aggressive behavior resulting in death within 2 years of the initial presentation. This presentation is unique, showing that peripheral lung tumors of salivary gland type are likely to be metastatic, and careful clinical evaluation is warranted in establishing their primary site of origin.

scholarly journals Warthin tumor of the oropharyngeal minor salivary gland

2018 ◽  
Vol 6 ◽  
pp. 2050313X1881871 ◽  
Author(s):  
Nicole Diaz-Segarra ◽  
Lauren K Young ◽  
Kristin Levin ◽  
William Rafferty ◽  
Joshua Brody ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Minor Salivary Gland ◽  
Previous History ◽  
Salivary Gland Tumor ◽  
Gland Tumor ◽  
Warthin Tumor ◽  
Diagnosis And Management ◽  
History Of ◽  
A Minor

Warthin tumor is the second most common benign salivary gland tumor that classically arises in the parotid gland. It can be synchronous, metachronous, multifocal, bilateral, or unilateral, which complicates diagnosis and management. Rare cases of Warthin tumor of the minor salivary gland are described, but no cases of unilateral, synchronous Warthin tumor involving the parotid and minor salivary gland have been reported. We present a case of Warthin tumor arising from a minor salivary gland in the left oropharynx of a 71-year-old male with a previous history of left parotid Warthin tumor, later determined to be synchronous.

scholarly journals Wegener’s granulomatosis mimicking a parotid abscess

2005 ◽  
Vol 119 (9) ◽  
pp. 746-749 ◽  
Author(s):  
G L Jones ◽  
A D Lukaris ◽  
H V Prabhu ◽  
M J K M Brown ◽  
J Bondeson
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Clinical Suspicion ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Surgical Exploration ◽  
First Case

We present the case of a previously healthy 59-year-old man who was under treatment for scleritis and episcleritis when he developed a parotid-gland swelling and pus-producing sinus. On surgical exploration, the features were those of a parotid abscess, but the lesion not only failed to heal post-operatively but increased in size very significantly. There was also severe necrotizing keratitis of the eyes. Due to clinical suspicion and a positive antineutrophil cytoplasmic antibodies test, Wegener’s granulomatosis was diagnosed and the patient successfully treated with cyclophosphamide and steroids. Previously, a number of cases of Wegener’s granulomatosis causing salivary-gland swelling have been reported in the literature; this is the first case in which the disease has masqueraded as a parotid abscess.

scholarly journals Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Toufik Mahfood Haddad ◽  
Muhammad Sarfraz Nawaz ◽  
Ahmed S. Abuzaid ◽  
Smrithy Upadhyay ◽  
Pallavi Bellamkonda ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Past History ◽  
Uncontrolled Hypertension ◽  
African American Female ◽  
Pericardial Disease ◽  
First Case ◽  
Segmental Wall Motion ◽  
Segmental Wall ◽  
History Of ◽  
Artery Disease

Hydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. Her medications included hydrochlorothiazide (HCTZ) which was started three months ago for uncontrolled hypertension. Significant laboratory parameters included erythrocyte sedimentation rate (ESR) of 47 mm/hr and peak troponin of 0.26 ng/mL. Transthoracic echocardiogram (TTE) revealed preserved ejection fraction with no segmental wall motion abnormalities; however, it showed moderate pericardial effusion without tamponade physiology. We hypothesize that this myopericarditis could be due to HCTZ allergic reaction after all other common etiologies have been ruled out. There is a scarcity of the literature regarding HCTZ as an etiology for pericardial disease, with only one case reported as presumed hydrochlorothiazide-induced pericardial effusion. Management involves discontinuation of HCTZ and starting anti-inflammatory therapy.

scholarly journals Hepatocellular Carcinoma Metastasis to the Orbit in a Coinfected HIV+ HBV+ Patient Previously Treated with Orthotopic Liver Transplantation: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
S. Guerriero ◽  
G. Infante ◽  
E. Giancipoli ◽  
S. Cocchi ◽  
M. G. Fiore ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Past History ◽  
Bone Biopsy ◽  
Biopsy Specimens ◽  
First Case ◽  
History Of ◽  
Previously Treated ◽  
Carcinoma Metastasis ◽  
End Stage ◽  
Irregular Mass

Hepatocellular carcinoma rarely metastasizes to the orbit. We report a 45-year-old male, HBV+, HIV+, with a past history of a liver transplant for ELSD (end-stage liver disease) with hepatocellular carcinoma and recurrent HCC, who presented with proptosis and diplopia of the left eye. CT scans of the head revealed a large, irregular mass in the left orbit causing superior and lateral destruction of the orbital bone. Biopsy specimens of the orbital tumor showed features of metastatic foci of hepatocellular carcinoma. Only 16 other cases of HCC metastasis to the orbit have been described in literature, and this is the first case in a previously transplanted HIV+, HBV+ patient.

scholarly journals Mixed cortico-medullary adrenal carcinoma in children: looks are deceptive!!

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Arti Khatri ◽  
Nidhi Mahajan ◽  
Niyaz Ahmed Khan ◽  
Natasha Gupta
Keyword(s):  
Past History ◽  
Case Reports ◽  
Final Diagnosis ◽  
Adrenal Carcinoma ◽  
Case Presentation ◽  
First Case ◽  
Contrast Enhanced ◽  
Paediatric Age ◽  
History Of ◽  
Enhanced Computed Tomography

Abstract Background Mixed cortico-medullary adrenal carcinoma (MCMAC) is an extremely rare entity with scarce literature on its cytomorphology. Case presentation A 2-year-old girl presented with abdominal pain for 3 days and a past history of fever with significant weight loss. On examination, a non-tender left hypochondrial firm mass and an enlarged left supraclavicular node were found. Twenty-four-hour urinary levels of VMA were marginally high. Contrast-enhanced computed tomography of the abdomen showed a suprarenal heterogeneous mass encasing major vessels. Aspiration cytology of both mass and node showed similar features comprising a predominant population of singly scattered large cells with moderate cytoplasm, eccentric nucleus and prominent nucleolus in a necrotic background. Tumour cells expressed Synaptophysin and Melan-A. In view of increasing respiratory distress, debulking surgery was performed, and histopathology of the specimen revealed the presence of both malignant medullary and cortical components supported by immunohistochemistry making a final diagnosis of MCMAC. The patient succumbed to death in the postoperative period. The cytology slides were reviewed and were seen to show a dual cell population. Conclusion Coexistent malignant cortical and medullary tumour of the adrenal gland is the first case reported in the paediatric age group in the literature with only three previous case reports in adults.

Presumed Choroidal Metastasis From Oncocytic Carcinoma of the Parotid Gland: A Case Report

2019 ◽  
Vol 4 (3) ◽  
pp. 253-256
Author(s):  
Yousef J. Cruz-Iñigo ◽  
Stephen A.M. De Souza
Keyword(s):  
Parotid Gland ◽  
External Beam Radiotherapy ◽  
Subretinal Fluid ◽  
Malignant Neoplasm ◽  
Distant Metastases ◽  
Choroidal Metastasis ◽  
Current Case ◽  
Oncocytic Carcinoma ◽  
History Of ◽  
The Right

Purpose: This article reports a case of presumed choroidal metastasis from an oncocytic carcinoma of the parotid gland. Methods: A 70-year-old man with history of an oncocytic carcinoma of the parotid gland presented owing to a 1-month history of progressive blurred central vision shortly after metastatic surveillance workup revealed liver, lung, and spine metastases. Fundus examination of the right eye showed a yellow choroidal mass surrounding the optic nerve and extending inferonasally, which is associated with subretinal fluid involving the foveal center. A-scan and B-scan ultrasonography were remarkable for a dome-shaped choroidal mass with medium-to-high internal reflectivity. Fluorescein angiography revealed pinpoint foci of hyperfluorescence over the choroidal lesion with late leakage. Magnetic resonance imaging of the brain showed evidence of metastatic disease to the cerebellum. While the patient underwent systemic chemotherapy, external beam radiotherapy was used to treat the eye. Results: Four months later, visual acuity improved, the tumor reduced in size, and the subretinal fluid resolved. Systemic workup disclosed no new metastases. Conclusion: Oncocytic carcinoma of the parotid gland is a rare and aggressive malignant neoplasm with frequent recurrences and distant metastases. The current case suggests that oncocytic carcinoma can metastasize to the choroid and, consequently, ocular metastasis surveillance is advised in these patients.

Apocrine Hidrocystoma of the Parotid Gland

2021 ◽  
pp. 014556132110310
Author(s):  
Ines Kharrat ◽  
Imen Achour ◽  
Wadii Thabet ◽  
Mohamed Amine Chaabouni ◽  
Majdi Trigui ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Histological Examination ◽  
Outpatient Clinic ◽  
French Literature ◽  
Sweat Glands ◽  
Cystic Tumor ◽  
Superficial Parotidectomy ◽  
Parotid Region ◽  
First Case ◽  
History Of

Apocrine hidrocystoma is a cystic tumor originating from apocrine sweat glands. It is predominantly located in the eyelid margins. Here, we report a case of apocrine hidrocystoma of the parotid gland in a 19-year-old man who was referred to our outpatient clinic with a 5-year history of a gradual swelling in the left parotid region. The patient underwent left superficial parotidectomy. Histological examination confirmed the diagnosis of apocrine hidrocystoma. The case is original by the tumor’s location: to the best of our knowledge, this could be the first case in English and French literature reporting an apocrine hidrocystoma affecting the parotid gland. The purpose of this article is to report our case and discuss its clinical and anatomopathological features as well as its differential diagnoses.

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