scholarly journals Merkel cell carcinoma: a case report and literature review

2019 ◽  
Vol 2019 (11) ◽  
Author(s):  
Nicholas Mulchan ◽  
Alberto Cayton ◽  
Armand Asarian ◽  
Philip Xiao
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Surgical Excision ◽  
Merkel Cell ◽  
Cutaneous Malignancy ◽  
Uncommon Presentation ◽  
Prevalent Virus ◽  
Time Of Presentation

Abstract Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy of neuroendocrine origin presenting as a painless, rapidly growing nodule. MCC often presents in elderly, fair-skinned individuals in sun-exposed areas. Diagnosis is often overlooked at time of presentation due to its rarity, but MCC is twice as deadly as malignant melanoma. There has been bigger interest in the disease due to increasing incidence and an association with the prevalent virus Merkel cell polyomavirus. This study describes an uncommon presentation of MCC as a right gluteal lesion in an Afro-Panamanian patient. The tumor was suspected to be fibrolipoma, but Immunohistochemistry revealed the diagnosis of MCC, as stains for CD56 and CK20 were positive. In addition to surgical excision, the patient was referred for adjuvant radiotherapy. This case report and literature review elucidates the clinical, histopathologic and management aspects of MCC, which will help in recognizing and treating these tumors.

scholarly journals Merkel Cell Carcinoma: Case Report and Literature Review

2020 ◽  
Vol 48 (01) ◽  
pp. 061-065
Author(s):  
Margarida Areias Marques Miranda ◽  
Pedro Mota ◽  
Pedro Cardoso ◽  
Alexandre Pereira ◽  
Vânia Oliveira
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Clinical Case ◽  
Surgical Excision ◽  
Merkel Cell ◽  
Review Of The Literature ◽  
Rare Type ◽  
Left Hand

AbstractMerkel Cell Carcinoma is a rare type of aggressive and often fatal neuroendocrine tumor of the skin.We report a clinical case of a 56-year-old female with a Merkel cell carcinoma on the left hand, without distant metastasis, treated with surgical excision of the lesion and radiotherapy.Based on this clinical case a research and review of the literature on this rare neoplasia was carried out.

Merkel Cell Carcinoma In Situ Arising in a Trichilemmal Cyst: A Case Report and Literature Review

2008 ◽  
Vol 30 (5) ◽  
pp. 458-461 ◽  
Author(s):  
Wei Su ◽  
Sonia M Kheir ◽  
Brenda Berberian ◽  
Clay J Cockerell
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Carcinoma In Situ ◽  
Merkel Cell ◽  
Trichilemmal Cyst

scholarly journals Primary retroperitoneal Merkel cell carcinoma: Case report and literature review

2016 ◽  
Vol 19 ◽  
pp. 21-24 ◽  
Author(s):  
Osvaldo A. Quiroz-Sandoval ◽  
Mario Cuellar-Hubbe ◽  
Leonardo S. Lino-Silva ◽  
Rosa A. Salcedo-Hernández ◽  
Horacio N. López-Basave ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell ◽  
Primary Retroperitoneal

scholarly journals Merkel Cell Carcinoma: A Case-Report of Rare Presentation of Merkel Cell Carcinoma, Non-Indolent Proliferative Type, Polyomavirus-Negative: Hypothesis of MolecularPathogenesis

2020 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Surgical Excision ◽  
Molecular Pathogenesis ◽  
Merkel Cell ◽  
Rare Presentation ◽  
Ki 67 ◽  
Tissue Mass ◽  
Pelvic Mri

Introduction: Merkel cell carcinoma (MCC) is a rare cutaneous indolent neuroendocrine cancer, arising from the Merkel cells of the stratum basalis, of the epidermis. This type of tumor commonly arises in sun-exposed areas, such as head, neck, and lower extremities. Here, we describe a rare presentation of non-indolent proliferative type Merkel cell carcinoma. Case Report: This is a case-report of a 70-year-old Caucasian man with no pertinent past medical history, presenting as a large painless violaceous necrotic irregular bordered rapidly growing lesion, reaching to 8x10x15 cm3, within one-year period, on the lower back region with surface ulceration. Pelvic MRI showed a multilobulated enhancing soft tissue mass measuring 8.7x10.4x15.1 cm3 at the left gluteal region with exophytic extension to the left paraspinal muscles. The patient was admitted, tangential surgical excision and debridement of left flank wound was performed with partial primary closure. Pathology showed features of Merkel cell, show diffuse dot-like positivity with CK20 and are negative for CK7, there is diffuse positivity with NSE, synaptophysin and CD56 with strong diffuse Ki-67 positivity noted in >65% of tumor cells. CD99 shows diffuse small faint dot-like paranuclear positivity. Discussion: Merkel cell carcinoma (MCC) is a rare, aggressive tumor that generally arises in sun-exposed regions. After an initial course of slow growth, starting as a painless violaceous non-pruritic domed-shaped lesion, the tumor becomes more aggressive, rapidly growing, with metastasis with local lymph nodes and regional tissue invasion. Sixty percent of tumors can rapidly grow within a three-month period after initial diagnosis. MCC is also clonally associated with is polyomavirus. MCC Contributing molecular pathogenesis is imperative to determining the causation of rare non-indolent MCC tumors, and its association with prognosis and treatment. In polyomavirus negative patients, consideration for molecular pathogenesis as etiology is imperative.

scholarly journals Merkel cell carcinoma of the vulva – case report and the literature review

2013 ◽  
Vol 84 (5) ◽  
Author(s):  
Joanna Jońska-Gmyrek ◽  
Piotr Bobkiewicz ◽  
Leszek Gmyrek ◽  
Agnieszka Żółciak-Siwińska ◽  
Bogusław Lindner ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell

Merkel cell carcinoma of the forehead area: a literature review and case report

2019 ◽  
Vol 23 (3) ◽  
pp. 365-373 ◽  
Author(s):  
Claudio Caldarelli ◽  
Umberto Autorino ◽  
Caterina Iaquinta ◽  
Andrea De Marchi
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell

scholarly journals Merkel Cell Carcinoma of Anal Canal: Case Report and Literature Review

2021 ◽  
pp. 245
Author(s):  
◽  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Physical Examination ◽  
Anal Canal ◽  
Cell Carcinoma ◽  
Neuroendocrine Tumor ◽  
Merkel Cell Carcinoma ◽  
Anal Pain ◽  
Merkel Cell ◽  
Chronic Anemia

Few cases of anal canal Merkel cell Carcinoma have been reported in the literature. Merkel Cell Carcinoma is rare neuroendocrine tumor which commonly found in sun-exposed areas such as extremities. We describe a case of 74-year-old male with anal canal Merkel Cell Carcinoma. He presented with peri-anal pain, tenesmus and itching. Besides, he was found to have chronic anemia. An anal nodule was found during per-rectum physical examination that was excised during endoscopy. Histological examination of the nodule confirmed the diagnosis of Merkel Cell Carcinoma. Thenceforward, patient died 7 months after diagnosis with marked metastatic disease despite initiation of Pembrolizumab therapy.

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