Ten-Year Course of Borderline Personality Disorder

Author(s):  
Kevin Johnson ◽  
Erica Robinson ◽  
Sarah Fineberg

This chapter provides a summary of a landmark study on borderline personality disorder. What is the long-term prognosis of those with borderline personality disorder (BPD) compared to those with major depressive disorder or other personality disorders? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The findings show a favorable long-term prognosis that is comparable to that of other psychiatric disorders; 85% of those with BPS show at least 12-months of continuous remission after ten years. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

Author(s):  
David Grunwald ◽  
Erica Robinson ◽  
Sarah Fineberg

This chapter provides a summary of a landmark study on borderline personality disorder. How does transference-focused psychotherapy, supportive therapy, and dialectical behavioral therapy compare in the treatment of borderline personality disorder? Starting with that question, the chapter describes the basics of this study, including funding sources, study location, who was studied, and how many patients participated in the study. The study design is described, as well as the study intervention, follow-up, endpoints, results, and finally a discussion of criticisms and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.


Author(s):  
David Saunders ◽  
Erica Robinson ◽  
Sarah Fineberg

This chapter provides a summary of a landmark study on borderline personality disorder. Is dialectical behavior therapy more effective than treatment offered by nonbehavioral psychotherapy experts in reducing suicidal behaviors and treating borderline personality disorder? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.


Author(s):  
Daniel Barron ◽  
Robert Ostroff

This chapter provides a summary of a landmark study on major depressive disorder. Is paroxetine or cognitive therapy more effective in treating patients with moderate to severe major depressive disorder? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.


2010 ◽  
Vol 197 (6) ◽  
pp. 456-462 ◽  
Author(s):  
Kate M. Davidson ◽  
Peter Tyrer ◽  
John Norrie ◽  
Stephen J. Palmer ◽  
Helen Tyrer

BackgroundLonger-term follow-up of patients with borderline personality disorder have found favourable clinical outcomes, with long-term reduction in symptoms and diagnosis.AimsWe examined the 6-year outcome of patients with borderline personality disorder who were randomised to 1 year of cognitive–behavioural therapy for personality disorders (CBT–PD) or treatment as usual (TAU) in the BOSCOT trial, in three centres across the UK (trial registration: ISRCTN86177428).MethodIn total, 106 participants met criteria for borderline personality disorder in the original trial. Patients were interviewed at follow-up by research assistants masked to the patient's original treatment group, CBT–PD or TAU, using the same measures as in the original randomised trial. Statistical analyses of data for the group as a whole are based on generalised linear models with repeated measures analysis of variance type models to examine group differences.ResultsFollow-up data were obtained for 82% of patients at 6 years. Over half the patients meeting criteria for borderline personality disorder at entry into the study no longer did so 6 years later. The gains of CBT–PD over TAU in reduction of suicidal behaviour seen after 1-year follow-up were maintained. Length of hospitalisation and cost of services were lower in the CBT–PD group compared with the TAU group.ConclusionsAlthough the use of CBT–PD did not demonstrate a statistically significant cost-effective advantage, the findings indicate the potential for continued long-term cost-offsets that accrue following the initial provision of 1 year of CBT–PD. However, the quality of life and affective disturbance remained poor.


Author(s):  
Michael E. Hochman

This chapter provides a summary of a landmark study in abdominal surgery. Does bariatric surgery in obese individuals reduce mortality? Starting with that question, it describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case involving possible bariatric surgery, including gastric banding, vertical banded gastroplasty, or gastric bypass, for an obese man who has not had success with dieting.


2015 ◽  
Vol 27 (1) ◽  
pp. 51-63 ◽  
Author(s):  
Bjørnar T. Antonsen ◽  
Elfrida H. Kvarstein ◽  
Øyvind Urnes ◽  
Benjamin Hummelen ◽  
Sigmund Karterud ◽  
...  

Author(s):  
Michael Maksimowski ◽  
Zheala Qayyum

This chapter provides a summary of a landmark study on major depressive disorder. What are the drug–placebo differences among antidepressants when both published and unpublished data are analyzed? Does antidepressant efficacy depend on the severity of initial depression scores? Starting with these questions, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The main finding from this meta-analysis is that antidepressant-placebo differences are inconsequential for mildly-to-moderately depressed patients and minimal for severely depressed patients. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.


2017 ◽  
Vol 31 (5) ◽  
pp. 590-605 ◽  
Author(s):  
Irene Alvarez-Tomás ◽  
Joaquim Soler ◽  
Arturo Bados ◽  
Ana Martín-Blanco ◽  
Matilde Elices ◽  
...  

Author(s):  
Zachary Engler ◽  
Robert Beech

This chapter provides a summary of a landmark study on bipolar disorder. What is the natural progression of symptoms in patients with bipolar I disorder? Overall, how long do people with bipolar I disorder spend with depressive, manic, or other affective symptoms versus periods of euthymia, without controlling treatment modality? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.


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