Autoimmune liver disease

2011 ◽  
Author(s):  
R. Mark Beattie ◽  
Anil Dhawan ◽  
John W.L. Puntis
Keyword(s):  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Sclerosing Cholangitis ◽  
Liver Disorder ◽  
Overlap Syndrome ◽  
Autoimmune Liver Disease ◽  
Autoimmune Sclerosing Cholangitis

Autoimmune hepatitis (AIH) 386Autoimmune hepatitis/sclerosing cholangitis overlap syndrome (ASC) 388In paediatrics, two forms of autoimmune liver disease are recognized: • Autoimmune hepatitis (AIH)• AIH/sclerosing cholangitis overlap syndrome (autoimmune sclerosing cholangitis, ASC).• Progressive inflammatory liver disorder, preferentially affecting females, characterized serologically by high levels of transaminases and IgG and presence of autoantibodies, and histologically by interface hepatitis in the absence of a known aetiology....

scholarly journals Autoimmune Hepatitis and Primary Sclerosing Cholangitis: An Overlap Syndrome Resistant to Azathioprine and Intolerant to Tacrolimus with Sepsis Mimicking Flare UP-A Clinical Dilemma

2020 ◽  
Vol 07 (02) ◽  
pp. 11-14
Author(s):  
Sharon T Mathews ◽  
Keyword(s):  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Kidney Injury ◽  
Scoring Systems ◽  
Overlap Syndrome ◽  
Rare Presentation ◽  
First Line Therapy ◽  
Progressive Liver Disease

Patients with autoimmune liver disease in a frequency of 7% -18% fit into the diagnostic criteria for more than one condition. Up to 12.5% of Autoimmune Hepatitis (AIH) and Primary Sclerosing Cholangitis (PSC) cohorts have a label of AIH/PSC overlap. There can be an unpredictable interval of many years between the diagnosis of the two conditions. There are scoring systems but no established criteria for the diagnosis of AIH/PSC overlap. Therefore, a diagnosis based on combination of biochemistry, autoantibody profile, cholangiogram, and liver histologyis made. Histopathology staging of AIH/PSC overlap influences therapeutic options and prognosis. There is beneficial role of immunosuppression, even though there is a higher relapse rate and evidence of progressive liver disease despite immunosuppression in some cases. Liver related outcomes in this overlap are better than PSC alone but are poorer than AIH. We herein report a rare presentation of an overlap syndrome with AIH and PSC in a patient in whom, treatment with first line therapy showed incomplete response and the salvage therapy was not tolerated, presenting with Acute Kidney Injury (AKI) and a clinical picture of sepsis resembling AIH flare.

Autoimmune hepatitis

2018 ◽  
Author(s):  
Satish Keshav ◽  
Alexandra Kent
Keyword(s):  
Liver Disease ◽  
Natural History ◽  
Autoimmune Hepatitis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Autoimmune Liver Disease ◽  
Diagnostic Approach ◽  
Primary Biliary Cholangitis ◽  
Disease Etiology

This chapter discusses autoimmune liver disease, including autoimmune hepatitis (AIH), primary biliary cholangitis, and primary sclerosing cholangitis. It explores definitions of the disease, etiology, typical symptoms, uncommon symptoms, demographics, natural history, complications, diagnostic approach and other diagnoses that should be considered, prognosis, and treatment.

Diagnosis of autoimmune sclerosing cholangitis in children with autoimmune hepatitis

2017 ◽  
Vol 66 (1) ◽  
pp. S360
Author(s):  
M. Ferreira ◽  
C. Gonçalves ◽  
S. Nobre ◽  
S. Ferreira ◽  
I. Gonçalves
Keyword(s):  
Autoimmune Hepatitis ◽  
Sclerosing Cholangitis ◽  
Autoimmune Sclerosing Cholangitis

scholarly journals Regulatory T‐cell conditioning endows activated effector T cells with suppressor function in autoimmune hepatitis/autoimmune sclerosing cholangitis

Hepatology ◽  
2017 ◽  
Vol 66 (5) ◽  
pp. 1570-1584 ◽  
Author(s):  
Rodrigo Liberal ◽  
Charlotte R. Grant ◽  
Muhammed Yuksel ◽  
Jonathon Graham ◽  
Alireza Kalbasi ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Autoimmune Hepatitis ◽  
Regulatory T Cell ◽  
Sclerosing Cholangitis ◽  
Effector T Cells ◽  
Suppressor Function ◽  
Autoimmune Sclerosing Cholangitis

scholarly journals Autoimmune Hepatitis-Primary Sclerosing Cholangitis Overlap Syndrome Complicated by Crohn’s Disease

Digestion ◽  
2010 ◽  
Vol 82 (1) ◽  
pp. 24-26 ◽  
Author(s):  
Talha A. Malik ◽  
Alexandra M. Gutierrez ◽  
Brendan McGuire ◽  
Jessica G. Zarzour ◽  
Faisal Mukhtar ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Autoimmune Hepatitis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Overlap Syndrome
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