Bronchiolitis obliterans and cryptogenic organizing pneumonia

2020 ◽  
pp. 4185-4190
Author(s):  
Vasilis Kouranos ◽  
A.U. Wells
Keyword(s):  
Bronchiolitis Obliterans ◽  
Immunosuppressive Agents ◽  
Clinical Signs ◽  
Classification Systems ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Diffuse Panbronchiolitis ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Systemic Symptoms ◽  
Tissue Matrix

The nomenclature of the bronchiolitides is complicated by the interchangeable use of pathological and clinical descriptions and a diversity of classification systems. The four primary histological patterns are: organizing pneumonia (also termed proliferative bronchiolitis and bronchiolitis obliterans organizing pneumonia); bronchiolitis obliterans (also termed obliterative bronchiolitis and constrictive bronchiolitis); follicular bronchiolitis; and diffuse panbronchiolitis. The most characteristic abnormality is a filling of alveoli with granulation tissue and buds of loose collagen and connective tissue matrix cells with a uniform appearance. Presentation is typically subacute with non-productive or minimally productive cough, insidious dyspnoea, and systemic symptoms including malaise, fever, or chills, weight loss, and myalgia. Clinical signs are non-specific. Corticosteroid therapy is usually effective, with other immunosuppressive agents given to fulminant cases or those that do not respond. Prognosis is usually good, with overall mortality less than 5%.

Bronchiolitis obliterans and cryptogenic organizing pneumonia

2010 ◽  
pp. 3382-3387
Author(s):  
A.U. Wells ◽  
Nicholas K. Harrison
Keyword(s):  
Case History ◽  
Bronchiolitis Obliterans ◽  
Classification Systems ◽  
Obliterative Bronchiolitis ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Diffuse Panbronchiolitis ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Follicular Bronchiolitis

Case History—A 77 yr old woman referred because her ‘pneumonia failed to clear’. The nomenclature of the bronchiolitides is complicated by the interchangeable use of pathological and clinical descriptions and a diversity of classification systems. The four primary histological patterns are (1) organizing pneumonia (also termed proliferative bronchiolitis and bronchiolitis obliterans organizing pneumonia); (2) bronchiolitis obliterans (also termed obliterative bronchiolitis and constrictive bronchiolitis); (3) follicular bronchiolitis; and (4) diffuse panbronchiolitis....

scholarly journals A Case of Cryptogenic Organizing Pneumonia Occurring in Crohn’s Disease

2005 ◽  
Vol 12 (8) ◽  
pp. 437-439 ◽  
Author(s):  
Pierluigi Carratù ◽  
Silvano Dragonieri ◽  
Maria Cristina Nocerino ◽  
Senia Maria Rosaria Trabucco ◽  
Donato Lacedonia ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bronchiolitis Obliterans ◽  
Clinical Findings ◽  
Organizing Pneumonia ◽  
Extraintestinal Manifestation ◽  
Cryptogenic Organizing Pneumonia ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Lung Histology

A 29 year-old-man with Crohn's disease, who developed diffuse pulmonary infiltrates and hypoxemia two months following oral administration of mesalazine, was examined. Clinical findings and computed tomography were suggestive of, and lung histology was diagnostic of, bronchiolitis obliterans organizing pneumonia, also known as cryptogenic organizing pneumonia. Although the data did not allow for definitive conclusions, they did suggest that the pulmonary disease was an extraintestinal manifestation of Crohn's disease, rather than an adverse reaction to mesalazine. In fact, the patient showed clinical, radiological and functional improvements, despite the treatment with mesalazine and the withdrawal of steroid therapy.

scholarly journals Cryptogenic Organizing Pneumonia in Tomm5–/– Mice

2012 ◽  
Vol 50 (1) ◽  
pp. 65-75 ◽  
Author(s):  
P. Vogel ◽  
R. W. Read ◽  
J. E. Rehg ◽  
G. M. Hansen
Keyword(s):  
Mitochondrial Membrane ◽  
Nuclear Dna ◽  
Mitochondrial Outer Membrane ◽  
Central Component ◽  
Outer Mitochondrial Membrane ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Almost All ◽  
Tissue Matrix

Almost all mitochondrial proteins are encoded in the nuclear DNA and synthesized in the cytosol as pre-proteins. There is a protein translocase located in the mitochondrial outer membrane that transports mitochondrial pre-proteins into mitochondria. The central component of this translocase of the outer mitochondrial membrane (TOMM) complex is TOMM40, and TOMM5 is one of three small subunits associated with TOMM40. Translocase of outer mitochondrial membrane 5 homolog ( Tomm5–/–) knockout mice demonstrated an unexpected lung-specific phenotype characterized by widespread intra-alveolar fibrosis. Although TOMM5-deficient mice tested normal in a very broad range of phenotyping assays, they displayed histopathological lesions in the lung that were consistent with those reported in humans with cryptogenic organizing pneumonia (COP), which is also known as bronchiolitis obliterans organizing pneumonia (BOOP). The lesions had a patchy distribution in the lung and were characterized by the presence of intraluminal fibrogenic buds consisting of fibroblasts and myofibroblasts embedded in a loose connective tissue matrix that occupied the lumina of alveoli and alveolar ducts, with preservation of underlying alveolar architecture. In addition to macrophages, which were numerous in affected and surrounding alveoli, eosinophils comprised the most common and widespread inflammatory cell. Taken together, the findings in Tomm5–/– mice provide yet another example of the value of histopathology as a baseline assay in high-throughput phenotyping systems.

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