Management during pregnancy
Physiologic haemodynamic changes during pregnancy carry a risk of cardiac complications in women with valvular disease. Mitral stenosis with valve area <1.5 cm² is poorly tolerated and percutaneous mitral commissurotomy is needed during pregnancy if symptoms persist under medical therapy. The risk of complications is lower with aortic stenosis when women were asymptomatic before pregnancy with preserved left ventricular function. Chronic regurgitations are generally well tolerated, even when severe, provided left ventricular systolic function is preserved. Surgery under cardiopulmonary bypass should be avoided during pregnancy due to the fetal risk. There is a high risk of thromboembolic complications during pregnancy in women with a mechanical prosthesis, leading to maternal mortality between 1-4%. The choice of the modalities of anticoagulant therapy should weigh fetal and maternal risks after careful patient information. Given its complexity and risks, the management of pregnant patients with valvular disease should be performed in multidisciplinary cardiac-obstetric team.