Severe iron deficiency anaemia

2013 ◽  
pp. 35-42
Author(s):  
Daniel Marks ◽  
Marcus Harbord
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Blood Loss ◽  
Iron Deficiency Anaemia ◽  
Parasite Load ◽  
Deficiency Anaemia ◽  
Iron Stores ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Developed World

Implication of iron deficiency Causes of iron deficiency Overt or occult bleeding Diagnosing iron deficiency Presentation and investigations Treatment Anaemia of chronic disease In the developed world, the commonest cause of iron deficiency anaemia (IDA) and its prelude iron deficiency is menstrual blood loss. Worldwide, hookworm infection is prevalent and causes IDA in those with heavy parasite load. About 4% of men/post-menopausal women have iron deficiency, and 1–2% have related IDA. Iron deficiency rises to ~20% in pre-menopausal women (remainder often have considerably reduced iron stores)....

scholarly journals Safety and Efficacy of Intravenous Ferric Carboxy Maltose in Iron Deficiency Anaemia During Postpartum Period

2018 ◽  
Vol 15 (3) ◽  
pp. 208-211 ◽  
Author(s):  
Vineet Mishra ◽  
Priyankur Roy ◽  
Khushali Gandhi ◽  
Sumesh Choudhary ◽  
Rohina Aggarwal ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Binding Capacity ◽  
World Health Organisation ◽  
World Health ◽  
Serious Adverse Events ◽  
Deficiency Anaemia ◽  
Iron Stores ◽  
Mild Anaemia ◽  
High Doses

Background: Iron deficiency is the commonest treatable cause of postpartum anaemia. Parenteral iron therapy results in faster and higher replenishment of iron stores and correction of haemoglobin levels with better compliance. Ferric Carboxy Maltose is an effective and a safe option which can be administered intravenously in single total correction dose without any serious adverse effects.The study was done to evaluate the efficacy and safety of Ferric Carboxy Maltose in the treatment of iron deficiency anaemia in post-natal patients.Methods: It was an open, single arm study including 615 women with diagnosis of Iron deficiency anaemia and haemoglobin (Hb) levels between 4gm% and 11gm% from January 2013 to December 2016. Intravenous Ferric Carboxy Maltose(500-1500mg) was administered and the improvement in haemoglobin levels and iron stores were assessed after three weeks of total dose infusion.Results: Out of the 615 women, 595 women were included in the analysis. Most of the women were in the age group of 27-30 years. Most of the women had mild anaemia as per World Health Organisation guidelines. Mean hemoglobin levels significantly increased over a period of three weeks after Ferric Carboxy Maltose administration. Other parameters like total iron binding capacity, Ferritin and Iron also had a significant improvement after Ferric Carboxy Maltose administration. No serious adverse events were observed after Ferric Carboxy Maltose.Conclusions: Intravenous Ferric Carboxy Maltose was an effective and a safe treatment option for iron deficiency anaemia and has an advantage of single administration of high doses without serious adverse effects.

MENSTRUAL BLOOD-LOSS IN IRON-DEFICIENCY ANÆMIA

The Lancet ◽  
1965 ◽  
Vol 286 (7409) ◽  
pp. 407-409 ◽  
Author(s):  
A. Jacobs ◽  
E.Blanche Butler
Keyword(s):  
Iron Deficiency ◽  
Blood Loss ◽  
Iron Deficiency Anaemia ◽  
Menstrual Blood ◽  
Menstrual Blood Loss ◽  
Deficiency Anaemia

scholarly journals Comparative study of efficacy and safety of parenteral iron sucrose versus ferric carboxymaltose in treatment of postpartum iron deficiency anaemia

2021 ◽  
Vol 11 (1) ◽  
pp. 100
Author(s):  
Ganesh N. Dakhle ◽  
Mrunalini V. Kalikar ◽  
Rujuta P. Fuke ◽  
Anisha S. Parmarthi ◽  
Mrunalini K. Chokhandre
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Iron Deficiency Anaemia ◽  
Maximum Dose ◽  
Iron Sucrose ◽  
Ferric Carboxymaltose ◽  
Care Hospital ◽  
Deficiency Anaemia ◽  
Iron Stores ◽  
Parenteral Iron

Background: Postpartum anaemia often leads to multiple clinical complications in mother as well as infant and iron supplementation with parenteral iron is the preferred treatment modality. The present study was planned to compare the efficacy and tolerability of IV iron sucrose and IV ferric carboxymaltose in treatment of postpartum iron deficiency anaemia.Methods: This randomized, parallel, open label, prospective 4-weeks study was conducted from June 2019 to December 2020 in women with postpartum anaemia admitted to obstetrics and gynaecology inpatient department of a tertiary care hospital. Women with postpartum iron deficiency anaemia (N=60) were randomly divided into two groups; receiving Injection iron sucrose (N=30, maximum dose 500 mg) or Injection ferric carboxymaltose (N=30, maximum dose 500 mg). Change in haemoglobin and serum ferritin levels from baseline to the end of 2 and 4 weeks of treatment were evaluated.Results: The results showed early, sustained and significant increase in the haemoglobin levels in both the groups. However, the difference was not significant between groups (p=0.2). Evaluation of replenishment of iron stores (serum ferritin) showed improvement in both the groups, however in FCM group the rise was found to be significant (p<0.05).Conclusions: FCM in a lower dose of 500mg was found to be safe and effective in significantly improving haemoglobin concentration as well as in replenishing iron stores in patients with postpartum anaemia.

scholarly journals Ferritin and iron studies in anaemia and chronic disease

2016 ◽  
Vol 54 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Ying Y Peng ◽  
James Uprichard
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Iron Overload ◽  
Iron Deficiency Anaemia ◽  
Iron Homeostasis ◽  
Red Cells ◽  
Pivotal Role ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Common Causes

Anaemia is a condition in which the number of red cells necessary to meet the body's physiological requirements is insufficient. Iron deficiency anaemia and the anaemia of chronic disease are the two most common causes of anaemia worldwide;1 iron homeostasis plays a pivotal role in the pathogenesis of both diseases. An understanding of how iron studies can be used to distinguish between these diseases is therefore essential not only for diagnosis but also in guiding management. This review will primarily focus on iron deficiency anaemia and anaemia of chronic disease; however, iron overload in anaemia will also be briefly discussed.

EP.WE.548The prevalence iron deficiency anaemia in patients with oesophago-gastric cancer

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Catherine McCollum ◽  
Khurram Khan ◽  
Rongkagorn Chuntamongkol ◽  
Matthew Forshaw
Keyword(s):  
Gastric Cancer ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Iron Level ◽  
Serum Iron Level ◽  
Blood Profile ◽  
Deficiency Anaemia ◽  
Adult Men ◽  
High Prevalence ◽  
Post Menopausal

Abstract Aims Blood loss from the gastrointestinal tract is the most common cause of iron deficiency anaemia (IDA) in adult men and post-menopausal women. Up to 10% of patients with IDA have underlying gastrointestinal cancer. The aim of this study was to investigate prevalence of IDA in patients with oesophago-gastric cancer. Methods A retrospective cohort study of all newly diagnosed oesophago-gastric cancers (adenocarcinoma and squamous cell carcinoma) and high grade dysplasia discussed at tertiary multi-disciplinary team meeting between October 2019 and September 2020. Electronic case notes and blood profile at presentation, including ferritin and serum iron level, were analysed. Patients who did not have blood profile within three months of presentation were excluded. Results A total of 349 patients were identified, 12 were excluded due to missing data. 226 (67.1%) were male and the mean age was 69.7 ± 11.7 years. 260 (77.2%) were referred from primary care. After initial investigations, 256 (76.0%) were oesophageal cancer, 248 (73.6%) were adenocarcinoma, and 134 (39.8%) were metastatic at presentation. 128 (38.0%) patients were anaemic: 30 (23.4%) microcytic, 88 (68.8%) normocytic and 10 (7.8%) macrocytic. 98 (76.6%) anaemic patients had ferritin and/or iron levels checked. Analysis of these identified 63 (49.2%) patients with bloods consistent with IDA: 22 (34.9%) microcytic, 40 (63.5%) normocytic, and 1 (1.6%) macrocytic. Conclusions This study confirms that while there is high prevalence of anaemia in patients presenting with oesophagi-gastric cancer, IDA was diagnosed in only half of these. The predominant form of anaemia identified in these patients is normocytic.

Sign in / Sign up

Export Citation Format

Share Document