Prothrombotic conditions

2018 ◽  
Author(s):  
Raza Alikhan
Keyword(s):  
Risk Factors ◽  
Arterial Thrombosis ◽  
Hypercoagulable State ◽  
Diagnosis And Management

The term thrombophilia is used to describe an individual who has a tendency to develop thrombosis. Arterial thrombosis is usually linked with classical risk factors such as age, smoking, hypertension, hyperlipidaemia, or diabetes; a thrombophilia assessment and workup is not usually considered in cases of arterial thrombosis. A clinically useful approach to the diagnosis and management of a patient with a venous thrombotic process is to categorize the disorder as either a primary (inherited) or secondary (acquired) hypercoagulable state. This topic addresses the diagnosis and management of prothrombotic conditions.

Does HbA1cc Play a Role in the Development of Cardiovascular Diseases?

2018 ◽  
Vol 24 (24) ◽  
pp. 2876-2882 ◽  
Author(s):  
Kailash Prasad
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Half Life ◽  
Serum Levels ◽  
Serum Glucose ◽  
Cvd Risk ◽  
Factors Affecting ◽  
Diagnosis And Management ◽  
Coronary Artery Atherosclerosis

Cardiovascular diseases (CVD) may be mediated through increases in the cardiovascular risk factors. Hemoglobin A1c (HbA1c) also called glycated hemoglobin is presently used for the diagnosis and management of diabetes. It has adverse effects on cardiovascular system. This review deals with its synthesis and effects on the cardiovascular system. The serum levels of HbA1c have been reported to be affected by various factors including, the lifespan of erythrocytes, factors affecting erythropoiesis, agents interfering glycation of Hb, destruction of erythrocytes, drugs that shift the formation of Hb, statins, and drugs interfering the HbA1c assay. Levels of HbA1c are positively correlated with serum glucose and advanced glycation end products ( AGE), but no correlation between AGE and serum glucose. AGE cannot replace HbA1c for the diagnosis and management of diabetes because there is no correlation of AGE with serum glucose, and because the half-life of protein with which glucose combines is only 14-20 days as compared to erythrocytes which have a half-life of 90-120 days. HbA1c is positively associated with CVD such as the carotid and coronary artery atherosclerosis, ischemic heart disease, ischemic stroke and hypertension.HbA1c induces dyslipidemia, hyperhomocysteinemia, and hypertension, and increases C-reactive protein, oxidative stress and blood viscosity that would contribute to the development of cardiovascular diseases. In conclusion, HbA1c serves as a useful marker for the diagnosis and management of diabetes. AGE cannot replace HbA1c in the diagnosis and management of diabetes. There is an association of HbA1c with CVD which be mediated through modulation of CVD risk factors.

Haemostatic Genetic Risk Factors in Arterial Thrombosis

2001 ◽  
Vol 86 (07) ◽  
pp. 374-385 ◽  
Author(s):  
Rachel Simmonds ◽  
José Hermida ◽  
Suely Rezende ◽  
David Lane
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Genetic Polymorphism ◽  
Genetic Risk ◽  
Arterial Thrombosis ◽  
Membrane Glycoprotein ◽  
Thrombotic Disease ◽  
Integral Role ◽  
Technical Simplicity ◽  
Digital Nature

SummaryHaemostasis plays an integral role in arterial thrombotic disease. However, establishing which of the factors are risk factors has proven surprisingly difficult. Because of its technical simplicity and digital nature, the study of haemostatic polymorphisms as risk factors has grown in popularity. Once established as a risk factor, a genetic polymorphism has the potential to aid selective prophylaxis and therapy of disease. Numerous reports have now been published on polymorphisms of coagulation and fibrinolytic factors, of coagulation and fibrinolytic inhibitory proteins, and of platelet membrane glycoprotein receptors. This article describes the polymorphisms and evaluates the results of these studies using the premises of consistency of within-report genotype/phenotype/disease relationships and consistency of outcome between studies. Many studies have been only of association between polymorphisms and disease, a type of study that is prone to error. Furthermore, the collective outcome of these studies has primarily been inconsistent. It is concluded that despite the early promise of polymorphisms as risk factors, fresh approaches differing in scale and design are now required to clarify their possible importance.

Arterial Thrombosis—Diagnosis and Management

2020 ◽  
pp. 191-203
Author(s):  
H. Patrick McNeil ◽  
Steven A. Krilis ◽  
Colin N. Chesterman
Keyword(s):  
Arterial Thrombosis ◽  
Diagnosis And Management

AWARENESS AND KNOWLEDGE OF OBSTRUCTIVE SLEEP APNEA AMONG THE MEHSANA POPULATION

2021 ◽  
pp. 53-55
Author(s):  
Darshan SodhaSodha ◽  
Shrish Srivastava ◽  
Ajay Kubavat
Keyword(s):  
Risk Factors ◽  
Social Media ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Disorders ◽  
Diagnosis And Management ◽  
Knowledge Questionnaire ◽  
Obstructive Sleep ◽  
Level Of Knowledge

Obstructive sleep apnea is one of the most common sleep disorders and is an increasingky prevalent condition that remains largely undiagnosed. An observational crosssectional survey conducted in Orthodontic department of Narsinhbhai Patel Dental College using OSA knowledge containing 24 questions including knowledge. questionnaire consisting 24 questions was prepared and circulated to mehsana population across mehsana via google forms. 1000 pediatricians were approached via various social media and whatsapp groups to ll up the google forms. We got 612 complete responses to consider in the study. The level of knowledge regarding diagnosis and management of OSA in the Mehsana population is not optimal. Large number 80.1% were not aware about OSA and 4.7% were aware about risk factors related to OSA.

Postpneumonectomy empyema: risk factors, prevention, diagnosis, and management

2019 ◽  
Vol 28 (2) ◽  
pp. 89-96
Author(s):  
Harmouchi Hicham ◽  
Issoufou Ibrahim ◽  
Sani Rabiou ◽  
Lakranbi Marouane ◽  
Ouadnouni Yassine ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chest Wall ◽  
Bronchopleural Fistula ◽  
Pleural Space ◽  
Late Period ◽  
Considerable Time ◽  
Goals Of Care ◽  
Acute Period ◽  
Diagnosis And Management ◽  
Contralateral Lung

Postpneumonectomy empyema is a collection of pus in the pleural space after removal of the underlying lung. Postpneumonectomy empyema is a serious complication responsible for high rates of morbidity and mortality. Several risk factors for the development of postpneumonectomy empyema have been highlighted in the literature. The association of postpneumonectomy empyema with a bronchopleural fistula increases the rate of mortality by flooding the remaining lung. The management of postpneumonectomy empyema depends on the timing of presentation and the presence or absence of a bronchopleural fistula. The goals of care in the acute period are mainly preservation of the contralateral lung and sterilization of the pleural space, which may take a considerable time. The aims in the late period are closure of the bronchopleural fistula, obliteration of the pleural space, and closure of the chest wall.

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