scholarly journals Discrepancy Between SAA and CRP levels Linked to the Difference of SAA/CRP ratio in Early Rheumatoid Arthritis

2021 ◽  
Author(s):  
Hiroshi Uda ◽  
Rika Ebisu ◽  
Keiji Maeda ◽  
Osamu Saiki
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Rheumatoid Arthritis ◽  
Serum Amyloid A ◽  
High Ratio ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
Follow Up Study ◽  
The Difference

Abstract Objectives Indeed, serum amyloid A (SAA) and C-reactive protein (CRP) reportedly seem to have moderate correlation, but discrepancies between CRP and SAA levels have often been reported in patients with early rheumatoid arthritis (ERA). This study aimed to determine the reasons for this discrepancy. Methods ERA patients (n = 206) were enrolled and treated with anti-RA drugs. Clinical features and disease activities were estimated. CRP and SAA levels were monitored, and the SAA/CRP ratio was compared. Correlations between CRP and SAA levels in individuals and between individuals, and disease activity scores were examined. Results In a follow-up study, the SAA/CRP ratio remained almost constant over time in the same patients. However, SAA/CRP ratios differed widely between patients (0.233–106.3). In patients with high SAA/CRP ratio (>6.52), many (26.2%) had abnormal SAA values only. In patients with low SAA/CRP ratio (<6.52), not a few (6.8%) exhibited abnormal CRP values only. Conclusions The SAA/CRP ratio remained virtually constant in the same patients but differed dramatically between patients, which clarifies the discrepancy between CRP and SAA levels. CRP is the better marker in low-ratio patients, but not in high-ratio patients; the SAA/CRP ratio is critical for its interpretation.

scholarly journals Predictive factors related to the progression of periodontal disease in patients with early rheumatoid arthritis: a cohort study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ana María Heredia-P ◽  
Gloria Inés Lafaurie ◽  
Wilson Bautista-Molano ◽  
Tamy Goretty Trujillo ◽  
Philippe Chalem-Choueka ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Disease Activity ◽  
Early Rheumatoid Arthritis ◽  
Predictive Factors ◽  
Related Protein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Generalised Linear Mixed Model

Abstract Background Rheumatoid arthritis (RA) and periodontal disease are inter-related conditions. However, factors predictive of periodontal disease progression in patients with early rheumatoid arthritis (eRA) are lacking. The aim of this study was to identify factors associated with the progression of clinical attachment loss (CAL) in interproximal dental sites of eRA patients. Methods Twenty-eight eRA patients were evaluated for the progression of CAL at 280 interproximal dental sites at 1 year of follow-up. Markers of RA activity (rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein), a marker of bone resorption (Dickkopf-related protein 1), Disease Activity Score 28 and Simple Disease Activity Index were included as potential systemic predictive factors. Plaque index, gingival index, pocket depth, clinical attachment level and Dickkopf-related protein 1 in crevicular fluid at baseline were included as potential local predictive factors. Data were analysed in a hierarchical structure using generalised linear mixed models for progression at each site (> 2 mm) during follow-up. Results C-reactive protein level was the most important predictive systemic factor for the progression of CAL. The mean CAL and a high degree of gingival inflammation in interproximal sites at baseline were important predictive local factors (p <  0.0001). Patients who received combined treatment with disease-modifying antirheumatic drugs and corticosteroids exhibited less CAL (p <  0.0001). The predictive value of the generalised linear mixed model for progression was 85%. Conclusions Systemic factors, including RA disease activity and baseline periodontal condition, were associated with periodontal progression. Pharmacological treatment may affect periodontal progression in patients with early RA.

scholarly journals COVID-19 AMONG DIABETES PATIENTS TYPE 2

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
Mozoun Dafer Alahmari
Keyword(s):  
T Lymphocyte ◽  
Serum Amyloid A ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A

A total of 74 COVID-19 diabetic patients were enrolled in the study. Twenty-seven patients (36.5%) were severely ill, and ten patients (13.5%) died. Severe patients had higher blood glucose, serum amyloid A (SAA), C reactive protein, and interleukin 6 levels than non-severe patients (P>  0.05). Severe patients had lower levels of albumin, cholesterol, high density lipoprotein, small and dense low density lipoprotein, and CD4 T lymphocyte counts than non-severe patients (P > 0.05). Reduced CD4 21 + T lymphocyte counts (OR = 0.988, 95 percent confidence interval [95 percent CI] 0.979–0.997) and elevated SAA levels (OR = 1.029, 95 percent CI 1.002–1.058) were found as risk variables for COVID- 19 severity with diabetes in a logistic regression analysis (P > 0.05). Keywords: COVID-19, Diabetes, Hyperglycemia, Dislipidemia, CD4+ T lymphocyte , follow up symptoms.

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