Single nucleotide polymorphisms (SNPs) in cytokine genes may alter the level
and function of secreted cytokine; therefore, SNPs can influence the immune
response. The aim of the present study was to determine the association of
TNF-? -308G/A single nucleotide polymorphism in tuberculosis patients in the
Azeri population of Iran. The TNF-308G/A single nucleotide polymorphism in
the promoter region was genotyped by using the allele-specific PCR method in
200 healthy controls and 124 tuberculosis patients. The distribution of
allele frequencies for TNF-? -308G/A polymorphism between control and
tuberculosis patient groups was not significant (P-value = 0.058, OR = 1.5).
Furthermore, no statistically significant association was found between TNF-?
-308G/A genotype and resistance/susceptibility to TB (P-value = 0.102). Our
results suggest that TNF-? -308G/A polymorphism has no measurable effect on
the development of tuberculosis in Azeri population of Iran.
The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function