Long-term treatment of IgA nephropathy with cyclosporin A-a preliminary report

This paper gives a description of the development and initial empirical testing of the Report Form for Aggressive Episodes, a behavioural rating scale used to measure displayed aggressive behaviour and the situational determinant(s) according to a list of 30 potential precipitants to aggression. Findings from a one-year study in a special secure unit for the long-term treatment of dangerous patients show very high rates of underreporting of aggressive episodes in ward journals and patient files compared to this scale. Illustrations of the clinical use of the scale are provided by scoring examples and two case vignettes.

Download Full-text

Efficacy and safety of long-term treatment with cyclosporin A for atopic dermatitis

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/j.1468-3083.2006.01877.x ◽

2007 ◽

Vol 21 (1) ◽

pp. 85-89 ◽

Cited By ~ 53

Author(s):

DJ Hijnen ◽

O ten Berge ◽

L Timmer-de Mik ◽

CAFM Bruijnzeel-Koomen ◽

MS de Bruin-Weller

Keyword(s):

Atopic Dermatitis ◽

Cyclosporin A ◽

Term Treatment ◽

Efficacy And Safety ◽

Long Term Treatment

Download Full-text

Long-term salvage therapy with cyclosporin A in refractory idiopathic thrombocytopenic purpura

Blood ◽

10.1182/blood.v99.4.1482 ◽

2002 ◽

Vol 99 (4) ◽

pp. 1482-1485 ◽

Cited By ~ 58

Author(s):

Giovanni Emilia ◽

Monica Morselli ◽

Mario Luppi ◽

Giuseppe Longo ◽

Roberto Marasca ◽

...

Keyword(s):

Cyclosporin A ◽

Idiopathic Thrombocytopenic Purpura ◽

Complete Response ◽

Term Treatment ◽

Thrombocytopenic Purpura ◽

Long Term Treatment ◽

Life Threatening ◽

Difficult Challenge

Treatment of severe, chronic idiopathic thrombocytopenic purpura (ITP) refractory to most usual therapies is a difficult challenge. Little information exists on the clinical use of cyclosporin A (CyA) in the treatment of ITP. This report describes long-term treatment with CyA (median, 40 months) and follow-up (median, 36.8 months) in 12 adult patients with resistant ITP. CyA used in relatively low doses (2.5-3 mg/kg of body weight per day) led to a clinical improvement in 10 patients (83.3%). Five had a complete response (41.1%), 4 a complete response to maintenance therapy (33.3%), and one a partial response (8.3%). Two patients had no response. Most patients with a response (60%) had a long-term remission (mean, 28.6 months) after discontinuation of CyA. One patient had a relapse of ITP 4 years after CyA therapy was stopped. Side effects were moderate and transient, even in patients dependent on continued CyA treatment. CyA seems to represent reasonable salvage treatment in severe, potentially life-threatening, refractory ITP.

Download Full-text

Long-term treatment with heparin dramatically reduced massive proteinuria in patients with advanced IgA nephropathy

Nephrology ◽

10.1046/j.1440-1797.7.s.39.x ◽

2002 ◽

Vol 7 ◽

pp. A114-A114

Author(s):

Y ITO ◽

T KAWAMURA ◽

M OGURA ◽

Y UTSUNOMIYA ◽

T HOSOYA

Keyword(s):

Iga Nephropathy ◽

Term Treatment ◽

Long Term Treatment

Download Full-text

The effects of Cyclosporin A and Heteropterys tomentosaon the rat liver

Anais da Academia Brasileira de Ciências ◽

10.1590/0001-3765201520130351 ◽

2015 ◽

Vol 87 (1) ◽

pp. 369-379 ◽

Cited By ~ 6

Author(s):

Karine M. de Freitas ◽

Jacqueline M. Almeida ◽

Juliana C. Monteiro ◽

Maria Aparecida S. Diamante ◽

Jéssica S.F. do Vale ◽

...

Keyword(s):

Side Effects ◽

Cyclosporin A ◽

Wistar Rats ◽

Term Treatment ◽

Immunosuppressive Drug ◽

Water Control ◽

Simultaneous Treatment ◽

Long Term Treatment ◽

Liver Morphology

Cyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosais a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa(administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15mg/kg/day), H. tomentosainfusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosaadministered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H. tomentosaadministration did not alter the parameters analyzed. Biochemical plasma dosages and liver stereology showed impairment caused by CsA-treatment after 21 days; these results were not observed after 56 days of treatment. The simultaneous treatment with CsA and H. tomentosafor 21 or 56 days did not alleviate nor accentuate CsA hepatic effects. The present study showed that the 21 days treatment with CsA caused more alteration to the liver than the 56 days treatment; this could be related to hepatic recovery after the long term treatment.

Download Full-text