A puzzling case of high serum creatinine in a healthy woman

Background: Hypothyroidism is a common endocrinal disorder caused by insufcient production of thyroid hormones. Subclinical hypothyroidism (SCH) can be dened as a state of high serum thyroid stimulating hormone (TSH) levels (less than 10µIU/ml) with normal serum free thyroxine (fT ) and triiodothyronine (fT ) levels in 4 3 the presence or absence of symptoms. Creatinine is a chemical waste product that is produced by muscle metabolism. Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Thyroid dysfunction can affect renal physiology and development, and on the other hand, kidney disorders can inuence thyroid function. This study was aimed to nd out the status of serum fT , fT ,TSH and serum creatinine levels in subclinical hypothyroid cases and 3 4 healthy controls. Materials and Methods: The present study is descriptive case control study, was conducted in the Department of Biochemistry, J.L.N. Medical College and Associated group of Hospitals, Ajmer (Raj.). 130 cases of subclinical hypothyroidism attending Medical OPD of J.L.N. Hospitals were included and 50 age-sex matched euthyroid controls were selected. Results: The mean serum creatinine levels were found to be signicantly high in subclinical hypothyroid cases(0.99 + 0.19 mg%) as compared to healthy controls (0.75 + 0.15 mg%), (p<0.0001). Conclusion: Serum creatinine can be used as a biomarker for early detection of subclinical hypothyroidism in general population to prevent the morbidity and mortality which are associated with hypothyroidism. Early diagnosis and intervention of subclinical hypothyroid and their cluster of risk factor can prevent the renal dysfunction.

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High Serum Creatinine in Acute Pancreatitis: A Marker for Pancreatic Necrosis?

The American Journal of Gastroenterology ◽

10.1038/ajg.2009.688 ◽

2010 ◽

Vol 105 (5) ◽

pp. 1196-1200 ◽

Cited By ~ 19

Author(s):

Paul Georg Lankisch ◽

Bettina Weber-Dany ◽

Patrick Maisonneuve ◽

Albert B Lowenfels

Keyword(s):

Acute Pancreatitis ◽

Serum Creatinine ◽

Pancreatic Necrosis ◽

High Serum

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High serum creatinine in early life of preterm infants predicts the severe retinopathy of prematurity: a retrospective single-centre study

10.21203/rs.3.rs-198997/v1 ◽

2021 ◽

Author(s):

Seong Phil Bae ◽

Sung Shin Kim ◽

Won-Ho Han ◽

Ho Kim ◽

Ji Won Koh ◽

...

Keyword(s):

Risk Factors ◽

Serum Creatinine ◽

Retinopathy Of Prematurity ◽

Very Low Birth Weight ◽

High Serum ◽

University Hospital ◽

Vlbw Infants ◽

Erythropoietin Production ◽

Single Centre Study ◽

Cell Synthesis

Abstract BACKGROUND Hypoxia and anemia are among the risk factors for retinopathy of prematurity (ROP). The kidneys are important organs that sense oxygen levels and regulate red blood cell synthesis via erythropoietin production. We investigated the contribution of abnormal renal function (reflected by serum creatinine [SCr] levels) to severe ROP in very low birth weight (VLBW) infants. METHODS In the present study, we enrolled 242 VLBW infants of gestational age (GA) ranging between 25 and 32 weeks who were admitted at Soonchunhyang Cheonan University Hospital between Nov 2014 and Dec 2019. The cut-off value for normal SCr for each GA group based was defined as 95th percentile of SCr based on a reference chart developed in a previous study. Risk factors for ROP requiring treatment were analyzed using logistic regression. RESULTS Of the 242 infants, 63 (26%) were high SCr group and 30 (12.4%) infants had ROP requiring treatment. GA (odds ratio 0.38, 95% confidence interval 0.23–0.61) and high SCr group (4.68 [1.10–19.90]) were independent factors for ROP requiring treatment. CONCLUSIONS In VLBW infants, high SCr within the first 4 weeks after birth is one of the risk factors for ROP requiring treatment.

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POSTERIOR URETHRAL VALVES WITH PERSISTENT HIGH SERUM CREATININE: THE VALUE OF PERCUTANEOUS NEPHROSTOMY

The Journal of Urology ◽

10.1097/00005392-200010000-00067 ◽

2000 ◽

pp. 1340-1344 ◽

Cited By ~ 1

Author(s):

AHMED M. GHALI ◽

TALAL EL MALKI ◽

KHALED Z. SHEIR ◽

ALBEIR ASHMALLAH ◽

TAREK MOHSEN

Keyword(s):

Serum Creatinine ◽

Percutaneous Nephrostomy ◽

High Serum ◽

Posterior Urethral Valves ◽

Urethral Valves

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Starting lithium in patients with compromised renal function – is it wise?

Journal of Psychopharmacology ◽

10.1177/0269881120936541 ◽

2020 ◽

pp. 026988112093654

Author(s):

Mihaela Golic ◽

Harald Aiff ◽

Per-Ola Attman ◽

Bernd Ramsauer ◽

Staffan Schön ◽

...

Keyword(s):

Renal Function ◽

Renal Impairment ◽

Serum Creatinine ◽

Severe Renal Impairment ◽

Lithium Treatment ◽

Observation Time ◽

High Serum ◽

Normal Serum ◽

Somatic Comorbidity ◽

Matching Criteria

Background: Little is known of the risks involved for patients who, at the start of lithium treatment, already have compromised renal function. Aims: To assess the risk of developing severe renal impairment (chronic kidney disease (CKD) 4–5) among those patients and to explore predictors for the progression. Methods: A retrospective longitudinal cohort study using data from Sahlgrenska University Hospital’s laboratory database 1981–2017. We compared the risk of developing CKD 4–5 in two patient cohorts: an exposed cohort of 83 patients who had high serum creatinine prior to start of lithium and a reference cohort of 83 patients with normal serum creatinine, matched by gender, duration of lithium treatment and age at the start of lithium treatment. The patients’ medical charts were reviewed and the Swedish Renal Registry was used to identify patients with renal replacement therapy. Results: There were no significant differences between the exposed and reference cohorts with respect to our matching criteria. Almost half the patients in the exposed cohort versus only 10% of the reference patients progressed to CKD 4–5 (HR 6.7, 95%CI 3.1–14.3, p < 0.001) during a mean observation time of more than 10 years. The progressors were older at the start of lithium treatment and were characterised by a higher burden of comorbid somatic diseases, in particular cardiovascular diseases. Conclusions: Compromised renal function prior to initiating lithium treatment increases the risk of developing severe renal impairment. Monitoring of renal function should include somatic comorbidity among older patients.

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High serum creatinine is associated with reduction of vision impaired in patients with NMOSD

Journal of Neuroimmunology ◽

10.1016/j.jneuroim.2017.06.003 ◽

2017 ◽

Vol 310 ◽

pp. 32-37

Author(s):

De-Sheng Zhu ◽

Lu Yu ◽

Mei Li ◽

Lu Han ◽

Xin-Xin Huang ◽

...

Keyword(s):

Serum Creatinine ◽

High Serum

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Falsely high serum creatinine concentration associated with severe methanol intoxication.

Clinical Chemistry ◽

10.1093/clinchem/29.1.205 ◽

1983 ◽

Vol 29 (1) ◽

pp. 205-208 ◽

Cited By ~ 5

Author(s):

A H WU ◽

R Stout ◽

R B McComb

Keyword(s):

Drinking Water ◽

Renal Disease ◽

Serum Creatinine ◽

Visual Impairment ◽

High Serum ◽

Serum Creatinine Concentration ◽

Foreign Material ◽

Creatinine Concentration ◽

Methanol Intoxication ◽

Laboratory Experimentation

Abstract A case of severe methanol intoxication (1300 mg/L) was associated with markedly increased serum creatinine (490 mg/L) despite normal urea values and the absence of any other signs of renal disease. These values declined progressively to normal, and the patient recovered with no visual impairment. Additional laboratory experimentation suggested that the high creatinine value was probably ascribable to some unknown foreign material(s) in the patient's blood that reacted with the alkaline picrate used in the measurement of creatinine. One of the presumed metabolites of methanol, formaldehyde, reacts with creatinine but the product does not react with picrate. We believe that the foreign material was derived from either commercial preparations of methanol or contaminants in the patient's drinking water.

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Use of free and transthyretin-bound retinol-binding protein in serum as tests of vitamin A status in humans: effect of high creatinine concentrations in serum

Clinical Chemistry ◽

10.1093/clinchem/36.4.674 ◽

1990 ◽

Vol 36 (4) ◽

pp. 674-676 ◽

Cited By ~ 5

Author(s):

B J Burri ◽

D D Bankson ◽

T R Neidlinger

Keyword(s):

Renal Failure ◽

Acute Renal Failure ◽

Vitamin A ◽

Serum Creatinine ◽

Binding Protein ◽

High Serum ◽

Retinol Binding Protein ◽

Creatinine Concentration ◽

Vitamin A Status ◽

Chromatographic Peaks

Abstract We measured immunologically active (apo + holo) retinol-binding protein (RBP), vitamin A-carrying (holo) free RBP, and transthyretin-bound (TTR) holo-RBP in serum from 34 retrospective cases of fluctuating acute renal failure. All subjects had high serum creatinine concentrations caused by renal failure. Apo + holo, holo-TTR-RBP, and (especially) holo-free RBP all correlated poorly but significantly with serum creatinine concentration. Therefore, the use of any form of RBP to measure vitamin A status may be of limited value in subjects with high creatinine concentrations in serum. However, molecular-exclusion HPLC may be able to distinguish increases in RBP concentration associated with renal failure from those caused by altered vitamin A status, because renal failure causes abnormalities in the number and retention times of chromatographic peaks as well as their areas.

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High serum creatinine nonlinearity: a renal vital sign?

AJP Renal Physiology ◽

10.1152/ajprenal.00025.2016 ◽

2016 ◽

Vol 311 (2) ◽

pp. F305-F309 ◽

Cited By ~ 5

Author(s):

Carlos E. Palant ◽

Lakhmir S. Chawla ◽

Charles Faselis ◽

Ping Li ◽

Thomas L. Pallone ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Serum Creatinine ◽

High Serum ◽

Warning Sign ◽

Improved Method ◽

Ckd Progression ◽

Creatinine Concentration ◽

Time To Death ◽

Early Warning Sign ◽

Stage 4

Patients with chronic kidney disease (CKD) may have nonlinear serum creatinine concentration (SC) trajectories, especially as CKD progresses. Variability in SC is associated with renal failure and death. However, present methods for measuring SC variability are unsatisfactory because they blend information about SC slope and variance. We propose an improved method for defining and calculating a patient's SC slope and variance so that they are mathematically distinct, and we test these methods in a large sample of US veterans, examining the correlation of SC slope and SC nonlinearity (SCNL) and the association of SCNL with time to stage 4 CKD (CKD4) and death. We found a strong correlation between SCNL and rate of CKD progression, time to CKD4, and time to death, even in patients with normal renal function. We therefore argue that SCNL may be a measure of renal autoregulatory dysfunction that provides an early warning sign for CKD progression.

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