scholarly journals Does angiotensin blockade influence graft outcome in renal transplant recipients with IgA nephropathy?

2006 ◽  
Vol 21 (12) ◽  
pp. 3550-3554 ◽  
Author(s):  
A. E. Courtney ◽  
P. T. McNamee ◽  
W. E. Nelson ◽  
A. P. Maxwell
Keyword(s):  
Renal Transplant ◽  
Iga Nephropathy ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Graft Outcome ◽  
Angiotensin Blockade

scholarly journals Complement Genes Strongly Predict Recurrence and Graft Outcome in Adult Renal Transplant Recipients with Atypical Hemolytic and Uremic Syndrome

2013 ◽  
Vol 13 (3) ◽  
pp. 663-675 ◽  
Author(s):  
M. Le Quintrec ◽  
J. Zuber ◽  
B. Moulin ◽  
N. Kamar ◽  
M. Jablonski ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Graft Outcome ◽  
Uremic Syndrome

65 CAN LYMPHOCYTE SUBSET DYNAMICS PREDICT GRAFT OUTCOME IN RENAL TRANSPLANT RECIPIENTS INDUCED WITH POLYCLONAL ANTIBODIES?

2004 ◽  
Vol 52 (Suppl 2) ◽  
pp. S356.6-S357
Author(s):  
J. S. Karam ◽  
K. Gillis ◽  
Y. Qazi ◽  
K. Tornatore ◽  
G. Blessios ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Polyclonal Antibodies ◽  
Lymphocyte Subset ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Graft Outcome

Clinicopathologic evaluation of IgA nephropathy in renal transplant recipients

2001 ◽  
Vol 33 (1-2) ◽  
pp. 1249-1253 ◽  
Author(s):  
K Toki ◽  
K Oka ◽  
M Kyo ◽  
K Yazawa ◽  
T Tanaka ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Iga Nephropathy ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Donor CYP3A5 Gene Polymorphism Alone Cannot Predict Tacrolimus Intrarenal Concentration in Renal Transplant Recipients

2020 ◽  
Vol 21 (8) ◽  
pp. 2976
Author(s):  
Mengyu Zhang ◽  
Soichiro Tajima ◽  
Tomohiro Shigematsu ◽  
Rao Fu ◽  
Hiroshi Noguchi ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Renal Transplant ◽  
Gene Polymorphism ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Renal Metabolism ◽  
Renal Tubular Cells ◽  
Transplant Patients ◽  
Graft Outcome ◽  
Cyp3a5 Gene

CYP3A5 gene polymorphism in recipients plays an important role in tacrolimus blood pharmacokinetics after renal transplantation. Even though CYP3A5 protein is expressed in renal tubular cells, little is known about the influence on the tacrolimus intrarenal exposure and hence graft outcome. The aim of our study was to investigate how the tacrolimus intrarenal concentration (Ctissue) could be predicted based on donor CYP3A5 gene polymorphism in renal transplant recipients. A total of 52 Japanese renal transplant patients receiving tacrolimus were enrolled in this study. Seventy-four renal biopsy specimens were obtained at 3 months and 1 year after transplantation to determine the donor CYP3A5 polymorphism and measure the Ctissue by liquid chromatography-tandem mass spectrometry (LC-MS-MS). The tacrolimus Ctissue ranged from 52 to 399 pg/mg tissue (n = 74) and was weak but significantly correlated with tacrolimus trough concentration (C0) at 3 months after transplantation (Spearman, r = 0.3560, p = 0.0096). No significant relationship was observed between the donor CYP3A5 gene polymorphism and Ctissue or Ctissue/C0. These data showed that the tacrolimus systemic level has an impact on tacrolimus renal accumulation after renal transplantation. However, donor CYP3A5 gene polymorphism alone cannot be used to predict tacrolimus intrarenal exposure. This study may be valuable for exploring tacrolimus renal metabolism and toxicology mechanism in renal transplant recipients.

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