scholarly journals Ga-67 scintigraphy in the differential diagnosis between acute interstitial nephritis and acute tubular necrosis: an experimental study

2010 ◽  
Vol 25 (10) ◽  
pp. 3277-3282 ◽  
Author(s):  
A. I. Joaquim ◽  
G. E. F. Mendes ◽  
P. F. F. Ribeiro ◽  
M. A. F. Baptista ◽  
E. A. Burdmann
2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Cho Won-Yong ◽  
Jun Yong Lee ◽  
Kim Hyunseo ◽  
Ki Joon Lim ◽  
Yang Jihyun ◽  
...  

2020 ◽  
Vol 35 (26) ◽  
Author(s):  
Hyunseo Kim ◽  
Sang Kyung Jo ◽  
Shin Young Ahn ◽  
Young Joo Kwon ◽  
Hajeong Lee ◽  
...  

2019 ◽  
Author(s):  
Hyunseo Kim ◽  
Sang Kyung ◽  
Shin Young Ahn ◽  
Young Joo Kwon ◽  
Hajeong Lee ◽  
...  

Abstract Background: Although emerging evidence suggest acute kidney injury (AKI) progress to chronic kidney disease (CKD), longterm renal outcome of AKI still remains unclear. Unlike glomerular diseases, AKI is usually diagnosed in the clinical context without kidney biopsies, and lack of histology might contribute to this uncertainty. Acute tubular necrosis (ATN) is the most common cause of AKI due to ischemia, toxin or sepsis. Acute interstitial nephritis (AIN), caused by drugs or autoimmune diseases is also increasingly recognized as an important cause of AKI. Methods: Among 8,769 biopsy series, 253 adults who were histologically diagnosed with ATN and AIN from 1982 to 2018 at five university hospitals were included. Demographic and pathological features that are associated with the development of end stage renal disease (ESRD) were also examined. Results: Rate of non-recovery of renal function at 6 month was significantly higher in the AIN (ATN vs AIN 49.3 vs 69.4%, p=0.007) with a 2.709-fold higher risk of non- recovery compared to ATN (95% CI: 1.203–6.470). During the mean follow up of 76.5±91.9 months, ESRD developed in 39.4% of patients with AIN, and 21.5% patients of ATN. The risk of ESRD was significantly higher in AIN (23.050; 95% CI: 2.420-219.533) and also in ATN (12.136; 95% CI, 1.186-24.235) compared to control with non-specific pathology. Older age, female gender, renal function at the time of biopsy and at 6 months, proteinuria and pathological features including interstitial inflammation and fibrosis, tubulitis, vascular lesion were significantly associated with progression to ESRD. Conclusions: Our study demonstrated that patients with biopsy proven ATN and AIN are at high risk of developing ESRD.


2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Farheen Shah-Khan ◽  
Marc H. Scheetz ◽  
Cybele Ghossein

Vancomycin (VAN) has been associated with acute kidney injury (AKI) since it has been put into clinical use in the 1950's. Early reports of AKI were likely linked to the impurities of the VAN preparation. With the advent of the more purified forms of VAN, the incidence of AKI related to VAN were limited to acute interstitial nephritis (AIN) or as a potentiating agent to other nephrotoxins such as Aminoglycosides. VAN as the sole etiologic factor for nephrotoxic acute tubular necrosis (ATN) has not been described. Here, we report a case of biopsy-proven ATN resulting from VAN.


2020 ◽  
Author(s):  
Hyunseo Kim ◽  
Sang Kyung ◽  
Shin Young Ahn ◽  
Young Joo Kwon ◽  
Hajeong Lee ◽  
...  

Abstract The authors have withdrawn this preprint due to author disagreement.


2012 ◽  
Vol 51 (17) ◽  
pp. 2469-2471 ◽  
Author(s):  
Takeshi Nishijima ◽  
Hirohisa Yazaki ◽  
Fumihiko Hinoshita ◽  
Daisuke Tasato ◽  
Kazufusa Hoshimoto ◽  
...  

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