FP406THE ROLE OF ACTIVIN SIGNALING IN THE PATHOGENESIS OF RENAL OSTEODYSTROPHY OF CKD-MBD

It seems that CAPD may improve some patients with osteomalacia but may be similar to hemodialysis in regard to osteitis fibrosa. However, long-term prospective evaluation of the incidence of bone disease in CAPD patients is necessary before we can determine how CAPD may alter the incidence and expression of renal osteodystrophy. We need more information before we can conclude that CAPD may improve pure osteomalacia. Finally, the data available are insufficient to clarify the role of vitamin D analogues in these patients.

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Renal osteodystrophy: Role of calcimimetics

American Journal of Kidney Diseases ◽

10.1053/ajkd.2003.50096 ◽

2003 ◽

Vol 41 (3) ◽

pp. S104-S107 ◽

Cited By ~ 3

Author(s):

Walter H. Hörl

Keyword(s):

Renal Osteodystrophy

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Potential role of cytokines in renal osteodystrophy

Nephrology Dialysis Transplantation ◽

10.1093/oxfordjournals.ndt.a027290 ◽

1996 ◽

Vol 11 (2) ◽

pp. 399-400 ◽

Cited By ~ 7

Author(s):

A. Ferreira ◽

P. Simon ◽

T. B. Drueke ◽

Beatrice ◽

Descamps-Latscha

Keyword(s):

Renal Osteodystrophy ◽

Potential Role

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The Role of Imaging Techniques in the Study of Renal Osteodystrophy

The American Journal of the Medical Sciences ◽

10.1097/00000441-200008000-00005 ◽

2000 ◽

Vol 320 (2) ◽

pp. 90-95 ◽

Cited By ~ 8

Author(s):

Pablo Ambrosoni ◽

I. Olaizola ◽

H. Caorsi ◽

A. Petraglia ◽

C. Heuguerot ◽

...

Keyword(s):

Renal Osteodystrophy ◽

Imaging Techniques

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Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1708037114 ◽

2017 ◽

Vol 114 (32) ◽

pp. 8596-8601 ◽

Cited By ~ 26

Author(s):

Wei Song ◽

Edward Owusu-Ansah ◽

Yanhui Hu ◽

Daojun Cheng ◽

Xiaochun Ni ◽

...

Keyword(s):

Mitochondrial Dysfunction ◽

Mitochondrial Function ◽

Target Genes ◽

Fat Body ◽

Mitochondrial Activity ◽

Rna Seq ◽

Mitochondria Dysfunction ◽

Activin Signaling ◽

Triglyceride Accumulation

Mitochondrial dysfunction has been associated with obesity and metabolic disorders. However, whether mitochondrial perturbation in a single tissue influences mitochondrial function and metabolic status of another distal tissue remains largely unknown. We analyzed the nonautonomous role of muscular mitochondrial dysfunction in Drosophila. Surprisingly, impaired muscle mitochondrial function via complex I perturbation results in simultaneous mitochondrial dysfunction in the fat body (the fly adipose tissue) and subsequent triglyceride accumulation, the major characteristic of obesity. RNA-sequencing (RNA-seq) analysis, in the context of muscle mitochondrial dysfunction, revealed that target genes of the TGF-β signaling pathway were induced in the fat body. Strikingly, expression of the TGF-β family ligand, Activin-β (Actβ), was dramatically increased in the muscles by NF-κB/Relish (Rel) signaling in response to mitochondrial perturbation, and decreasing Actβ expression in mitochondrial-perturbed muscles rescued both the fat body mitochondrial dysfunction and obesity phenotypes. Thus, perturbation of muscle mitochondrial activity regulates mitochondrial function in the fat body nonautonomously via modulation of Activin signaling.

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