scholarly journals SURG-08. GASTROINTESTINAL STROMAL TUMOR WITH INTRACRANIAL METASTASIS: CASE REPORT AND SYSTEMATIC REVIEW OF LITERATURE

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i32-i32 ◽  
Author(s):  
Akash Patel
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Stromal Tumors ◽  
Primary Site ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Patient Case ◽  
Intracranial Metastasis ◽  
Stromal Tumors ◽  
Metastatic Gist ◽  
The Brain

Abstract BACKGROUND: Intracranial metastasis of Gastrointestinal Stromal Tumors (GIST) is rare but presents unique treatment challenges. We present a case of intracranial metastasis of GIST with a systematic review of the literature regarding this rare clinical scenario. METHODS: A systematic review of the literature was performed to identify cases of intradural GIST metastases to the brain. Additionally, a patient case of GIST is discussed. RESULTS: Out of the 18 articles included for analysis in this review and our present case, fifteen of nineteen patients were male, and mean age was 58 years old (range 15–80 years, median 60 years). The primary site of the GIST along with site of intraperitoneal metastasis was variable. There was a large predilection for brain metastasis to the cerebrum with only one to infratentorial elements. The tumors in seven of the cases involved the dura, and there was one case with metastasis to the pituitary. Eight patients died following treatment of their intracranial disease. CONCLUSIONS: Surgery remains the mainstay of intracranial metastatic GIST, however there are many reports of good responses to radiation or chemotherapy alone. More investigation is required to determine the best course of treatment for patients with this unusual sequela of GIST.

scholarly journals Management of self-inflicted orchiectomy in psychiatric patient. Case report and non-systematic review of the literature

2018 ◽  
Vol 90 (3) ◽  
pp. 220-223
Author(s):  
Marco Garofalo ◽  
Alessandro Colella ◽  
Paolo Sadini ◽  
Lorenzo Bianchi ◽  
Giacomo Saraceni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Emergency Surgery ◽  
Psychiatric Evaluation ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Patient Case ◽  
Left Testicle ◽  
Rare Phenomenon ◽  
First Choice ◽  
Choice Of Treatment

Introduction: Self-inflicted orchidectomy and auto-castration, also known as “Eshmun complex” is a rare phenomenon. The aim of our study it to present the management of a patient who performed a self orchiectomy and propose a non-systematic review of literature about self-orchiectomy. Material and method: A 27-years old male Patient with psychiatric disorder was admitted to our ward to have been cutted his scrotum with scissors and cut away his left testicle causing active bleeding from the left spermatic artery. The patient underwent emergency surgery with clamping of the spermatic cord and hemostasis of the wound. Results: After surgery the clinical condition of the patient remained good during whole hospitalization. Urgent psychiatric evaluation was performed in order to administer proper therapy for acute management. To best of our knowledge, only 11 cases of self-orchidectomy are reported in literature and all of them except 1 case, underwent surgical exploration. Conclusions: Self-orchidectomy is an extremely rare phenomenon, often associated with psychiatric disorders, compounded by the use of drugs. In our opinion, emergency surgery should be the first choice of treatment, offering diagnostic and hemostatic purpose in a single act, aimed to prevent acute and postacute complications.

scholarly journals Medical Adjuvants in the Treatment of Surgically Refractory Arteriovenous Malformations of the Head and Face: Case Report and Review of Literature

2021 ◽  
pp. 1-7
Author(s):  
Vaidya Govindarajan ◽  
Joshua D. Burks ◽  
Evan M. Luther ◽  
John W. Thompson ◽  
Robert M. Starke
Keyword(s):  
Arteriovenous Malformations ◽  
Mtor Inhibitors ◽  
Molecular Target ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Early Results ◽  
Number Of Patients ◽  
Initiation Of Therapy ◽  
The Brain ◽  
Radiographic Improvement

<b><i>Background:</i></b> Arteriovenous malformations (AVMs) of the brain and face present unique challenges for clinicians. Cerebral AVMs may induce hemorrhage or form aneurysms, while facial AVMs can cause significant disfigurement and pain. Moreover, facial AVMs often draw blood supply from arteries providing critical blood flow to other important structures of the head which may make them impossible to treat curatively. Medical adjuvants may be an important consideration in the management of these patients. <b><i>Summary:</i></b> We conducted a systematic review of the literature to identify other instances of molecular target of rapamycin (mTOR) inhibitors used as medical adjuvants for the treatment of cranial and facial AVMs. We also present 2 cases from our own institution where patients were treated with partial embolization, followed by adjuvant therapy with rapamycin. After screening a total of 75 articles, 7 were identified which described use of rapamycin in the treatment of inoperable cranial or facial AVM. In total, 21 cases were reviewed. The median treatment duration was 12 months (3–24.5 months), and the highest recorded dose was 3.5 mg/m<sup>2</sup>. 76.2% of patients demonstrated at least a partial response to rapamycin therapy. In 2 patients treated at our institution, symptomatic and radiographic improvement were noted 6 months after initiation of therapy. <b><i>Key Messages:</i></b> Early results have been encouraging in a small number of patients with inoperable AVM of the head and face treated with mTOR inhibitors. Further study of medical adjuvants such as rapamycin may be worthwhile.

scholarly journals Skeletal Muscle Metastasis of a GIST: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Olga D. Savvidou ◽  
George D. Chloros ◽  
Georgios D. Agrogiannis ◽  
Penelope Korkolopoulou ◽  
Georgios N. Panagopoulos ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Case Report ◽  
Soft Tissue ◽  
Gastrointestinal Stromal Tumors ◽  
Review Of The Literature ◽  
Soft Tissue Metastasis ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Skeletal Muscle Metastasis ◽  
Muscle Metastasis

Gastrointestinal stromal tumors (GISTs) are the most common malignant mesenchymal tumors of the gastrointestinal tract. The most common sites of metastasis are the liver and the peritoneum, whereas metastasis to soft tissue is rare. The authors present the case of a 78-year-old male with a soft tissue metastasis of a GIST and the current literature is reviewed.

Gastrointestinal stromal tumors: report of an audit and review of the literature

2009 ◽  
Vol 18 (2) ◽  
pp. 106-116 ◽  
Author(s):  
Guido Biasco ◽  
Daniela Velo ◽  
Imerio Angriman ◽  
Maria Astorino ◽  
Anna Baldan ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Review Of The Literature ◽  
Stromal Tumors

Systematic review of current prognostication systems for primary gastrointestinal stromal tumors

2018 ◽  
Vol 44 (4) ◽  
pp. 388-394 ◽  
Author(s):  
Chun Yuet Khoo ◽  
Xun Chai ◽  
Richard QUEK ◽  
Melissa C.C. Teo ◽  
Brian K.P. Goh
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors
Sign in / Sign up

Export Citation Format

Share Document