Evaluation and management of a spontaneous corneal rupture secondary to pellucid marginal degeneration, using swept-source anterior segment optical coherence tomography

Abstract We describe a case of bilateral spontaneous corneal perforation secondary to pellucid marginal degeneration and present the associated swept-source anterior segment optical coherence tomography (SS-ASOCT) findings and management principles used. A 47-year-old woman presented with ocular pain, redness, foreign body sensation and clear discharge in the right eye in 2017 and with very similar symptoms in 2019 in the left eye. Clinically she had a corneal perforation at the inferior cornea with associated loss of anterior chamber volume. Corneal topography demonstrated peripheral thinning and steepening in the contralateral eye. ASOCT images revealed full-thickness perforation, iridocorneal touch and iris stranding. The patient was managed with a combination of contact bandaging and corneal gluing. SS-ASOCT is a useful adjunctive tool in the clinical assessment and evaluation of spontaneous corneal perforation. Alongside the clinical evaluation, it can be used to monitor the clinical response.

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Observation of anterior chamber volume after cataract surgery with swept-source optical coherence tomography

International Ophthalmology ◽

10.1007/s10792-018-1012-1 ◽

2018 ◽

Vol 39 (8) ◽

pp. 1837-1844

Author(s):

Minjie Chen ◽

Hailin Hu ◽

Wenwen He ◽

Yi Lu ◽

Xiangjia Zhu

Keyword(s):

Optical Coherence Tomography ◽

Cataract Surgery ◽

Anterior Chamber ◽

Optical Coherence ◽

Swept Source ◽

Chamber Volume ◽

Anterior Chamber Volume

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Serial anterior segment optical coherence tomography post autologous simple limbal epithelial transplantation

BMJ Case Reports ◽

10.1136/bcr-2020-236692 ◽

2020 ◽

Vol 13 (12) ◽

pp. e236692

Author(s):

Anahita Kate ◽

Swapna S Shanbhag ◽

Ritin Goyal ◽

Sayan Basu

Keyword(s):

Optical Coherence Tomography ◽

Anterior Segment ◽

Human Amniotic Membrane ◽

Optical Coherence ◽

Long Term Follow Up ◽

Limbal Stem Cell ◽

Contralateral Eye ◽

The Right

A 24-year-old young man presented to us with total limbal stem cell deficiency (LSCD) in the right eye 1 year post ocular chemical burn. The patient subsequently underwent limbal biopsy in the healthy contralateral eye and autologous simple limbal epithelial transplantation in the right eye. The patient was followed up with sequential imaging of the cornea with high-resolution anterior segment optical coherence tomography (HR-ASOCT) for 3 years. The serial HR-ASOCT imaging in the operated eye showed regeneration of the epithelium from the limbal transplant over the human amniotic membrane (hAM) with integration of the transplant within the cornea with subepithelial retention of the hAM. Over the long-term follow-up, thinning of the hAM and thickening of the epithelium was noted. At 3 years, the cornea maintained an intact epithelium with no signs of recurrence of LSCD.

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Evaluation of anterior chamber volume using Pentacam and anterior segment optical coherence tomography among normal subjects

Asian Journal of Ophthalmology ◽

10.35119/asjoo.v16i2.367 ◽

2018 ◽

Vol 16 (2) ◽

pp. 86-94

Author(s):

Vijaya Anandan ◽

Rekha Srinivasan ◽

Rashima Asokan ◽

Ronnie George

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Anterior Segment ◽

Normal Subjects ◽

Optical Coherence ◽

Cross Sectional ◽

Chamber Volume ◽

Anterior Chamber Volume ◽

Volume Measurements ◽

The Mean

Aim: To compare the anterior chamber volume measurements obtained with Pentacam and derived from anterior segment optical coherence tomography. Design: Cross-sectional study. Methods: We included normal subjects who underwent a comprehensive eye examination including refraction, keratometry, Goldmann applanation tonometry, gonioscopy, anterior segment optical coherence tomography (AS-OCT) (Carl Zeiss Meditec Inc.; Dublin, CA, USA) and Pentacam (Oculus Inc.; Lynnwood, WA, USA). Fifty scans were selected for Pentacam and 12 images were selected for calculation of anterior chamber volume. Only the right eye was considered for analysis. Results: One-hundred and nineteen eyes of 119 subjects were included for analysis. The mean age of the subjects was 42.58 ± 13.15 years, of which 74 were female and 45 were male. The mean anterior chamber volume measured using AS-OCT was 119.17 ± 26.56 mm3 and with Pentacam was 131.29 ± 34.26 mm3. The comparison of means between the two modalities was statistically significant (t = -8.857, Mean Difference (MD) = 12.11, 95% CI: (4.29, 19.95), p = 0.003). Bland-Altman plot showed poor agreement between the chamber volume measurements obtained by Pentacam and AS-OCT with MD of 12.1 mm3 (95 % CI: 41.4 to -17.1) and intra-class correlation between the two instruments was 0.94 (95% CI: 0.91, 0.96) (p < 0.0001). Conclusion: The anterior chamber volume can be measured using Pentacam as well as AS-OCT since these measurements were reliable. However, these measurements were not interchangeable due to poor levels of agreement.

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Repeatability and reproducibility of anterior chamber volume measurements using 3-dimensional corneal and anterior segment optical coherence tomography

Journal of Cataract & Refractive Surgery ◽

10.1016/j.jcrs.2010.08.053 ◽

2011 ◽

Vol 37 (3) ◽

pp. 461-468 ◽

Cited By ~ 18

Author(s):

Shinichi Fukuda ◽

Keisuke Kawana ◽

Yoshiaki Yasuno ◽

Tetsuro Oshika

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Anterior Segment ◽

Optical Coherence ◽

3 Dimensional ◽

Chamber Volume ◽

Anterior Chamber Volume ◽

Volume Measurements ◽

Repeatability And Reproducibility

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Objective quantification of lens nuclear opacities using swept-source anterior segment optical coherence tomography

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2020-318334 ◽

2021 ◽

pp. bjophthalmol-2020-318334

Author(s):

Wei Wang ◽

Jiaqing Zhang ◽

Xiaoxun Gu ◽

Xiaoting Ruan ◽

Xiaoyun Chen ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Anterior Segment ◽

Training Dataset ◽

Dissipated Energy ◽

Nuclear Density ◽

Optical Coherence ◽

Nuclear Cataract ◽

Swept Source ◽

Ultrasonic Time

Background/aimsThe primary objective is to quantify the lens nuclear opacity using swept-source anterior segment optical coherence tomography (SS-ASOCT) and to evaluate its correlations with Lens Opacities Classification System III (LOCS-III) system and surgical parameters. The secondary objective is to assess the diagnostic performance for hard nuclear cataract.MethodsThis cross-sectional study included 1222 patients eligible for cataract surgery (1222 eyes). The latest SS-ASOCT (CASIA-2) was used to obtain high-resolution lens images, and the average nuclear density (AND) and maximum nuclear density (MND) were measured by a custom ImageJ software. Spearman’s correlations analysis was used to assess associations of AND/MND with LOCS-III nuclear scores, visual acuity and surgical parameters. The subjects were then split randomly (9:1) into the training dataset and validating dataset. Receiver operating characteristic curves and calibration curves were constructed for the classification on hard nuclear cataract.ResultsThe AND and MND from SS-ASOCT images were significantly correlated with nuclear colour scores (AND: r=0.716; MND: r=0.660; p<0.001) and nuclear opalescence scores (AND: r=0.712; MND: r=0.655; p<0.001). The AND by SS-ASOCT images had the highest values of Spearman’s r for preoperative corrected distance visual acuity (r=0.3131), total ultrasonic time (r=0.3481) and cumulative dissipated energy (r=0.4265). The nuclear density had good performance in classifying hard nuclear cataract, with area under the curves of 0.859 (0.831–0.886) for AND and 0.796 (0.768–0.823) for MND.ConclusionObjective and quantitative evaluation of the lens nuclear density using SS-ASOCT images enable accurate diagnosis of hard nuclear cataract.

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