Anesthetics

Author(s):  
Jie Jack Li

The easiest pain to bear is someone else’s. In the preanesthesia era, the prospect of surgery was so terrifying that it was not uncommon for a tough-hearted man to commit suicide rather than go through that unbearable, excruciating agony. It is hard to believe t hat t here was a time when nothing was effective to a lleviate surgical pain. The patients were simply strapped down and that was it. As a consequence, speed was the most important attribute of a surgeon in those days. A great English surgeon, Robert Liston at the University College Hospital, once boasted that he had amputated a leg in 29 seconds, along with a testicle of his patient and a finger of his assistant. The operation rooms were often strategically located at the tops of towers in the hospitals to keep fearful screams from being heard. During wartime, surgeries were even worse than battlefield injuries, because during the fight soldiers were temporarily “hypnotized” and became oblivious to pain. Before anesthesia, surgeons resorted to whatever means were available to deaden the pain oft heir patients during operations. The three most popular methods were alcohol, ice, and narcotics. Legend has it that a surgeon first conceived the idea of operating during a patient’s alcoholic coma when he noticed that a drunkard had had parts of his face chewed away by a hog but was not aware of it during a drunken stupor. Chinese surgeon Bian Què (401–310 B.C.) was reported to have operated on a patient’s brain using herbal extracts to render him unconscious more than 2,000 years ago. Hua Tuo (115–205 A.D.) made his patients take an effervescing powder (possibly cannabis) in wine that produced numbness and insensibility before surgical operations. Cold deadens pain by slowing the rate impulse conduction by nerve fiber. Some surgeons used ice to numb limbs before amputations. This method was invented by Baron Dominique Jean Larrey (1766–1842), surgeon of Napoleon’s Grande Armée.

Author(s):  
Biobele J. Brown ◽  
Regina E. Oladokun ◽  
Babatunde O. Ogunbosi ◽  
Kikelomo Osinusi

Introduction: This study describes the epidemiologic features and clinical course of children with blood transfusion-associated HIV infection (TAHI) in Ibadan, Nigeria. Methodology: All children diagnosed to have TAHI at the University College Hospital, Ibadan, were studied and compared with children who acquired HIV vertically using the pediatric HIV database in the hospital. Results: Transfusion-associated HIV infection accounted for 14 (2.3%) of the 597 children diagnosed to have HIV infection between January 2004 and December 2011. The mean age at diagnosis of TAHI was 10.2 years and that of vertically acquired HIV infection was 3.9 years ( P < .001). In 9 cases, blood transfusion took place in private hospitals and in 5 cases in public hospitals. Median interval between infection and diagnosis of AIDS was 84 months in cases with TAHI and 48 months in vertically acquired cases ( P = .542). Conclusion: Optimal blood safety practices are advocated for prevention of TAHI in Nigeria.


Author(s):  
Abiodun Adeoso ◽  
Tola Atinmo

Recent upsurge of cancer cases across the globe is of concern to all and many studies shows the relationship between nutrient and the immune system and consequently cancer. This work aims to compare the dietary pattern, anthropometry and serum ascorbate status of the persons living with and those living without non-Hodgkin’s lymphoma (NHL). A case-control study was conducted using blood samples of eight patients diagnosed for NHL at the University College Hospital (UCH) Ibadan, while eight (8) volunteers were the control group. Socio-economic characteristics, medical history, food preferences, anthropometric indices were retrieved from questionnaires. Ascorbic Serum assay done with ultraviolet absorption spectrophotometry method using Klett-summerson photoelectric. Students’ t-test and Chi-square were used to test the educational levels fruit consumption. 25% of the respondents suffering from NHL skipped lunch and dinner, but none skipped breakfast. 66.67% of the cases and 100% of the control have their weight normally distributed. Cases had 11.11% slightly underweight and 11.11% obese. 25% of the population of the respondents had normal range of 0.4 mg/100 of serum ascorbate, while six had low serum ascorbate levels.


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