scholarly journals Sequential estrogen receptor determinations from primary breast cancer and at relapse: Prognostic and therapeutic relevance

1992 ◽  
Vol 3 (9) ◽  
pp. 733-740 ◽  
Author(s):  
V. Spataro ◽  
K. Price ◽  
A. Goldhirsch ◽  
F. Cavalli ◽  
E. Simoncini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Primary Breast Cancer ◽  
Therapeutic Relevance

scholarly journals Neoadjuvant endocrine therapy for estrogen receptor-positive primary breast cancer

2020 ◽  
Vol 9 (3) ◽  
pp. 30-30
Author(s):  
Yutaka Yamamoto ◽  
Lisa Goto-Yamaguchi ◽  
Masako Takeno ◽  
Mutsuko Yamamoto-Ibusuki
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Endocrine Therapy ◽  
Primary Breast Cancer ◽  
Neoadjuvant Endocrine Therapy ◽  
Estrogen Receptor Positive

Phosphorylation of Estrogen Receptor β at Serine 105 in Primary Breast Cancer.

2009 ◽  
Author(s):  
W. Hamilton-Burke ◽  
A. Shaaban ◽  
M. Cummings ◽  
D. Holliday ◽  
S. Pollock ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Primary Breast Cancer ◽  
Estrogen Receptor Β

Microsomal Epoxide Hydrolase Expression as a Predictor of Tamoxifen Response in Primary Breast Cancer: A Retrospective Exploratory Study With Long-Term Follow-Up

2001 ◽  
Vol 19 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Peter Fritz ◽  
Thomas E. Mürdter ◽  
Michel Eichelbaum ◽  
Isabel Siegle ◽  
Matthias Weissert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Prognostic Factor ◽  
Exploratory Study ◽  
Primary Breast Cancer ◽  
Epoxide Hydrolase ◽  
Disease Outcome ◽  
Tamoxifen Treatment ◽  
Microsomal Epoxide Hydrolase

PURPOSE: It has been suggested that estrogen receptor–independent high-affinity binding sites for antiestrogens could limit their local bioavailability and response. Microsomal epoxide hydrolase (mEH) was recently shown to be a component of the antiestrogen binding site complex. We investigated whether mEH expression in primary breast tumors is related to disease outcome and to the efficacy of tamoxifen treatment. PATIENTS AND METHODS: Expression of mEH was semiquantitatively assessed by immunohistochemistry in sections prepared from archival paraffin blocks of primary breast cancers from 179 patients with a mean follow-up time of 81 months. RESULTS: Expression of mEH was correlated with poor disease outcome in all patients (P < .01; n = 179) and in patients receiving tamoxifen (P < .01; n = 78), but not in patients not treated with tamoxifen. Moreover, mEH was an independent prognostic factor by Cox regression analysis. CONCLUSION: The results of this first exploratory study suggest that mEH expression in primary breast cancer could be of predictive value for response to tamoxifen treatment and/or may be a novel independent prognostic factor for survival. The results are in agreement with the model that mEH participates in an estrogen receptor–independent tamoxifen- binding complex.

Muss der ER-Grenzwert neu definiert werden?

2018 ◽  
Vol 50 (02) ◽  
pp. 82-84
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Clinical Oncology ◽  
Primary Breast Cancer ◽  
Estrogen Receptor Positivity ◽  
American Society ◽  
Definition Of ◽  
Er Expression

Fujii T, Kogawa T, Dong W et al. Revisiting the definition of estrogen receptor positivity in HER2-negative primary breast cancer. Ann Oncol 2017; 28: 2420–2428 Gemäß den Empfehlungen der „American Society of Clinical Oncology“ sowie der Fachgesellschaft der US-Pathologen werden Mammakarzinome mit einer ER-Expression < 1% als rezeptornegativ bewertet. Wissenschaftliche Untersuchungen deuten jedoch darauf hin, dass diese Tumoren in molekulargenetischer und prognostischer Hinsicht Karzinomen mit einer ER-Expression zwischen 1 und 9% ähneln. Sollte der Grenzwert angehoben werden?

Differences in expression of proliferation-associated genes and RANKL across the menstrual cycle in estrogen receptor-positive primary breast cancer

2014 ◽  
Vol 148 (2) ◽  
pp. 327-335 ◽  
Author(s):  
Ben P. Haynes ◽  
Giuseppe Viale ◽  
Viviana Galimberti ◽  
Nicole Rotmensz ◽  
Bianca Gibelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Menstrual Cycle ◽  
Primary Breast Cancer ◽  
Estrogen Receptor Positive

Correlation of primary breast cancer histopathology and estrogen receptor content

1981 ◽  
Vol 1 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Edwin R. Fisher ◽  
C. Kent Osborne ◽  
William L. McGuire ◽  
Carol Redmond ◽  
William A. Knight ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Primary Breast Cancer
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