A RECESSIVE CURLY-HAIR CHARACTER OF THE NORWAY RAT

We have reported that the myogenic response of the renal afferent arteriole (Af-art) and middle cerebral artery (MCA) and autoregulation of renal and cerebral blood flow are impaired in Fawn-Hooded Hypertensive (FHH) rats. Transfer of a region of chromosome 1 containing γ-adducin (Add3) from the Brown Norway rat rescued the vascular dysfunction and the development of renal disease. To examine whether Add3 is a viable candidate gene altering renal and cerebral hemodynamics in FHH rats, we knocked down the expression of Add3 in rat Af-arts and MCAs cultured for 36-h using a 27-mer Dicer-substrate short interfering RNA (DsiRNA). Control Af-arts constricted by 10 ± 1% in response to an elevation in pressure from 60 to 120 mmHg but dilated by 4 ± 3% when treated with Add3 DsiRNA. Add3 DsiRNA had no effect on the vasoconstrictor response of the Af-art to norepinephrine (10−7 M). Add3 DsiRNA had a similar effect on the attenuation of the myogenic response in the MCA. Peak potassium currents were threefold higher in smooth muscle cells isolated from Af-arts or MCAs transfected with Add3 DsiRNA than in nontransfected cells isolated from the same vessels. This is the first study demonstrating that Add3 plays a role in the regulation of potassium channel function and vascular reactivity. It supports the hypothesis that sequence variants in Add3, which we previously identified in FHH rats, may play a causal role in the impaired myogenic response and autoregulation in the renal and cerebral circulation.

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Age-associated changes in mitogen-induced lymphoproliferation and lymphokine production in the long-lived brown-norway rat: effect of caloric restriction

Mechanisms of Ageing and Development ◽

10.1016/0047-6374(95)01609-4 ◽

1995 ◽

Vol 83 (2) ◽

pp. 103-116 ◽

Cited By ~ 17

Author(s):

I.Michael Goonewardene ◽

Donna M. Murasko

Keyword(s):

Caloric Restriction ◽

Brown Norway ◽

Norway Rat ◽

Lymphokine Production ◽

Brown Norway Rat

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Kinetics of bromadiolone, anticoagulant rodenticide, in the norway rat (Rattus norvegicus)

Pharmacological Research Communications ◽

10.1016/0031-6989(87)90011-7 ◽

1987 ◽

Vol 19 (11) ◽

pp. 767-775 ◽

Cited By ~ 17

Author(s):

Nahas Kamil

Keyword(s):

Rattus Norvegicus ◽

Anticoagulant Rodenticide ◽

Norway Rat ◽

Kinetics Of

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Field trials of flocoumafen against warfarin-resistant infestations of the Norway rat (Rattus norvegicus Berk)

Journal of Hygiene ◽

10.1017/s0022172400066250 ◽

1986 ◽

Vol 96 (3) ◽

pp. 467-473 ◽

Cited By ~ 15

Author(s):

A. P. Buckle

Keyword(s):

Rattus Norvegicus ◽

Field Trials ◽

Anticoagulant Rodenticide ◽

Complete Control ◽

Norway Rat ◽

Norway Rats ◽

Farm Buildings

SUMMARYThe anticoagulant rodenticide flocoumafen was tested against warfarin-resistant Norway rats (Rattus norvegicus Berk.) infesting farm buildings. Complete control was obtained in 10–21 days (mean 14·2 days) in six treatments in which baits poisoned with 0·005% flocoumafen were maintained, in surplus, until rats ceased to feed from them. A further six treatments, in which the application of poisoned bait was restricted to periodic placements of 50 g, were also completely successful in 15–30 days (mean 21·0 days). Less poisoned bait was used in the restricted flocoumafen treatments than in the unrestricted treatments but the time taken to control the rat infestations was significantly longer.

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