scholarly journals Calcinosis cutis in limited cutaneous systemic sclerosis

QJM ◽  
2021 ◽  
Author(s):  
Sumantro Mondal ◽  
Debanjali Sinha ◽  
Alakendu Ghosh
Keyword(s):  
Systemic Sclerosis ◽  
Soft Tissue ◽  
Clinical Image ◽  
Soft Tissue Calcification ◽  
Radiographic Image ◽  
Calcinosis Cutis ◽  
Tissue Calcification ◽  
Rheumatological Diseases

Abstract Soft tissue calcification is seen in some rheumatological diseases, including systemic sclerosis. We herein present a clinical image of calcinosis cutis of finger pulps and its characteristic radiographic image in a patient with limited cutaneous systemic sclerosis.

Systemic sclerosis skin is a primed microenvironment for soft tissue calcification—a hypothesis

Rheumatology ◽  
2021 ◽  
Author(s):  
Kyle A. Burgess ◽  
Ariane L. Herrick ◽  
Rachel E. B. Watson
Keyword(s):  
Soft Tissue ◽  
Type I Collagen ◽  
Driving Forces ◽  
Clinical Problem ◽  
Therapeutic Interventions ◽  
Type I ◽  
Soft Tissue Calcification ◽  
Calcinosis Cutis ◽  
Tissue Calcification ◽  
Digital Ischaemia

Abstract Calcinosis cutis, defined as sub-epidermal deposition of calcium salts, is a major clinical problem in patients with SSc, affecting 20–40% of patients. A number of recognized factors associated with calcinosis have been identified, including disease duration, digital ischaemia and acro-osteolysis. Yet, to date, the pathogenesis of SSc-related calcinosis remains unknown, and currently there is no effective disease-modifying pharmacotherapy. Following onset of SSc, there are marked changes in the extracellular matrix (ECM) of the skin, notably a breakdown in the microfibrillar network and accumulation of type I collagen. Our hypothesis is that these pathological changes reflect a changing cellular phenotype and result in a primed microenvironment for soft tissue calcification, with SSc fibroblasts adopting a pro-osteogenic profile, and specific driving forces promoting tissue mineralization. Considering the role of the ECM in disease progression may help elucidate the mechanism(s) behind SSc-related calcinosis and inform the development of future therapeutic interventions.

Widespread soft tissue calcification in systemic sclerosis, polymyositis, and polyarthritis

The Lancet ◽  
2021 ◽  
Vol 397 (10272) ◽  
pp. 409
Author(s):  
Ole Hudowenz ◽  
Philipp Klemm ◽  
Uwe Lange ◽  
Ulf Mueller-Ladner
Keyword(s):  
Systemic Sclerosis ◽  
Soft Tissue ◽  
Soft Tissue Calcification ◽  
Tissue Calcification

scholarly journals Spinal Stenosis Caused by Calcinosis in a Patient With Systemic Sclerosis

2021 ◽  
pp. jrheum.201389
Author(s):  
Tal Gazitt ◽  
Joy Feld ◽  
Devy Zisman
Keyword(s):  
Systemic Sclerosis ◽  
Soft Tissue ◽  
Spinal Stenosis ◽  
Juvenile Dermatomyositis ◽  
Phosphorus Metabolism ◽  
Soft Tissue Calcification ◽  
Connective Tissues ◽  
Tissue Calcification ◽  
Calcium Phosphorus ◽  
Normal Calcium

Calcinosis or dystrophic soft-tissue calcification occurs in damaged/devitalized tissues in the presence of normal calcium/ phosphorus metabolism.1 It is a known complication of connective tissues diseases, especially juvenile dermatomyositis and systemic sclerosis (SSc), and may be localized or widespread.2

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