Role of diffusion weighted magnetic resonance imaging in assessment of urinary bladder cancer

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mahmoud Mohamed S Al Thqaby ◽  
Sherif H Abu-Gamrah ◽  
Ayman M Ibrahem ◽  
Ahmed M Hussein ◽  
Mohamed Elazab
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Pathological Examination ◽  
Low Grade ◽  
Bladder Tumors ◽  
T Stage ◽  
Diffusion Weighted ◽  
Contrast Enhanced ◽  
The Mean

Abstract Purpose The aim of this work is to ellucidate the role of diffusion-weighted imaging in T-stage of bladder cancer, to find correlation between the apparent diffusion coefficient (ADC) and histologic grade and to detect early tumor recurrence. Materials and Methods In this retrospective study, 34 patients were gathered, 28 men and 6 women, with ages ranging from 46 to 90 years, presented with gross hematuria or suspected of urinary bladder tumors detected on U/S and/or CT examinations. The patients were referred to Radiology department at national cancer institute for MRI examination after fulfilling inclusion and exclusion criteria. The urinary bladder tumors were classified in accordance with TNM classification from the American Joint Committee on Cancer into: T1 or lower, T2 (T2a or T2b), T3 (T3a or T3b), and T4.The mean ADC value of patients with low grade tumor (G1) and patients with high grade tumor (G2 or G3) was done The results were compared with histo-pathological examination obtained by transurethral resection (TUR) or after radical cystectomy. Results The overall accuracy of T stage diagnosis was 74.29% for T2-weighted images, 88.57 % for DW images, 80 % for contrast-enhanced images, and about 88.57 % for T2 plus DWIs. The mean ADC of G3 tumors was significantly lower than that of G1 and G2 tumors. Conclusion Our results suggest that adding DWIs to T2WIs lead to marked improvement regarding the accuracy for differentiating T2 or lower tumors from T3 and higher tumors, helping to limit the usage of contrast enhanced MRI imaging as a noninvasive diagnostic tool.

scholarly journals Role of Diffusion Weighted MRI in Evaluation of Urinary Bladder Cancer in Iraqi Patient in Correlation with Histopathological Grade.

2017 ◽  
Vol 12 (02) ◽  
pp. 74-77
Author(s):  
Dr. Khaleel Ibraheem Mohson MBChB, CABMS(Rad) ◽  
Dr. Mohammed Bassil Ismail, MBChB,CABMS(uro) ◽  
Dr. Sura Tami Abduljabbar , MBChB
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Urinary Bladder Cancer ◽  
Diffusion Weighted Mri ◽  
Histopathological Grade ◽  
Diffusion Weighted

Urinary Bladder Cancer: Diffusion-weighted MR Imaging—Accuracy for Diagnosing T Stage and Estimating Histologic Grade

Radiology ◽  
2009 ◽  
Vol 251 (1) ◽  
pp. 112-121 ◽  
Author(s):  
Mitsuru Takeuchi ◽  
Shigeru Sasaki ◽  
Masato Ito ◽  
Shinsuke Okada ◽  
Satoru Takahashi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Mr Imaging ◽  
Urinary Bladder Cancer ◽  
Histologic Grade ◽  
T Stage ◽  
Diffusion Weighted

scholarly journals Effectiveness of contrast-enhanced ultrasound for detecting the staging and grading of bladder cancer: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Xinyue Ge ◽  
Zhong-Kai Lan ◽  
Jing Chen ◽  
Shang-Yong Zhu
Keyword(s):  
Bladder Cancer ◽  
Diagnostic Accuracy ◽  
Likelihood Ratio ◽  
Positive Likelihood Ratio ◽  
Cochrane Library ◽  
Forest Plot ◽  
Low Grade ◽  
High Grade ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

Aim: The study retrospectively analysed the accuracy of preoperative contrast-enhanced ultrasound (CEUS) in differenti-ating stage Ta-T1 or low-grade bladder cancer (BC) from stage T2 or high-grade bladder cancer. Material and methods: We systematically searched the literature indexed in PubMed, Embase, and the Cochrane Library for original diagnostic articles of bladder cancer. The diagnostic accuracy of CEUS was compared with cystoscopy and/or transurethral resection of bladder tumors (TURBT). The bivariate logistic regression model was used for data pooling, couple forest plot, diagnostic odds ratio (DOR) and summary receiver operating characteristic (SROC). Results: Five studies met the selection criteria; the overall number of reported bladder cancers patients were 436. The pooled-sensitivity (P-SEN), pooled-specificity (P-SPE), pooled-positive likelihood ratio (PLR+), pooled-negative likelihood ratio (PLR−), DOR, and area under the SROC curve were 94.0% (95%CI: 85%–98%), 90% (95%CI: 83%–95%), 9.5 (95%CI: 5.1–17.6), 0.06 (95%CI: 0.02–0.17), 147 (95%CI: 35–612) and 97% (95% CI: 95%–98%) respectively. Conclusion: CEUS reaches a high efficiency in discriminating Ta-T1 or low-grade bladder cancer from stage T2 or high-grade bladder cancer. It can be a promising method in patients to distinguish T staging and grading of bladder cancer because of its high sensitivity, specificity and diagnostic accuracy.

scholarly journals Combination role of DAPK methylation in urinary sediment and B ultrasound in evaluating follow-up of urinary bladder cancer

2020 ◽  
Author(s):  
Linlin Wang ◽  
Fuquan Jiang ◽  
Changfeng Li ◽  
Jiansong Han
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
High Performance ◽  
Urinary Bladder Cancer ◽  
Youden Index ◽  
Urinary Sediment ◽  
Negative Results ◽  
Kappa Test

Abstract Background: Urinary bladder cancer (UBC) is a highly prevalent disease and is associated with substantial morbidity, mortality and cost. This paper aims to explore the combination role of DAPK methylation in urinary sediment and B ultrasound in diagnosing recurrent UBC. Methods: A total of 1021 cases of primary UBC undergone electrocision of bladder tumor through urethra were included and were subjected to follow up every 3 month within 2 years. B ultrasound, DAPK methylation in urinary sediment, examination of exfoliated cells in urine and cystoscopy were performed during the follow up. The data recorded in follow up were subjected to chi-square test and Kappa test. ROC was drawn to evaluate the diagnostic role of each parameter in recurrent UBC. Results: Among the 1021 patients, 115 patients were found with recurrent UBC by cystoscopy and biopsy two years after the operation, and failed to complete the follow up, thus the effective number of follow up was 906. The cystoscopy results were not only consistent with that of B ultrasound (Kappa = 0.785, P < 0.05), but also agreed with that of DAPK methylation in urinary sediment and combination of B ultrasound with DAPK methylation (Kappa = 0.517, P < 0.05, Kappa = 0.593, P < 0.05). ROC curve indicated that the area under curve of combination of B ultrasound with DAPK methylation was 0.922 (sensitivity, 92.86%; specificity, 91.63%; Youden index, 0.845) with negative prediction value of 99.4% which suggested that the recurrent risk would be low in case negative results were obtained. Conclusion: Those data supported that combination of DAPK methylation with B ultrasound has high performance in diagnosing recurrent UBC.

Treatment of Large Non-Muscle-Invasive Bladder Cancer: The Potential Role of Neoadjuvant Intravesical Chemotherapy

2020 ◽  
pp. 1-6
Author(s):  
Marco Raber ◽  
Noor Buchholz ◽  
Augusto Vercesi ◽  
Nashaat A. Hendawi ◽  
Vincenzo Inneo ◽  
...  
Keyword(s):  
Potential Role ◽  
Tumor Volume ◽  
Neoadjuvant Treatment ◽  
Complete Resection ◽  
Bladder Mucosa ◽  
Bladder Tumors ◽  
Muscle Invasive Bladder Cancer ◽  
The Mean ◽  
Muscle Invasive

<b><i>Introduction:</i></b> The endoscopic resection of large and bulky bladder cancers represents a challenge. To reduce the tumor and make it more easy to resect, we used neoadjuvant short and intensive intravesical mitomycin (MMC) therapy. <b><i>Methods:</i></b> Patients with large bladder tumors were evaluated for this study. At cystoscopy, the surgeon evaluated the feasibility of complete resection. In patients where this was not possible, biopsies from the tumor, bladder mucosa, and prostatic urethra were taken. These patients then underwent a short and intensive cytoreductive schedule of intravesical MMC. This was then followed by TUR-BT. <b><i>Results:</i></b> Fifteen patients were included in our study. The mean age was 74 years (range: 56–82; SD ±6 years). Mean tumor size was 51 mm (range: 35–65; SD ±8 mm). After neoadjuvant treatment, complete resection was then feasible in all patients. The mean tumor volume after the chemo-resection had reduced to 34 mm (range: 10–50; SD ±13 mm). No adverse effects were reported. <b><i>Conclusion:</i></b> Intravesical cytoreductive neoadjuvant MMC as an initial treatment of large NMIBC can be considered safe, effective, and feasible.

Sign in / Sign up

Export Citation Format

Share Document