scholarly journals REM sleep-dependent short-term and long-term hourglass processes in the ultradian organization and recovery of REM sleep in the rat

SLEEP ◽  
2020 ◽  
Vol 43 (8) ◽  
Author(s):  
Adrián Ocampo-Garcés ◽  
Alejandro Bassi ◽  
Enzo Brunetti ◽  
Jorge Estrada ◽  
Ennio A Vivaldi
Keyword(s):  
Sleep Deprivation ◽  
Rem Sleep ◽  
Transition Probability ◽  
Nrem Sleep ◽  
Short Term ◽  
Rem Sleep Deprivation ◽  
Sleep Episode ◽  
Organization Of Sleep ◽  
Sleep Transition

Abstract Study Objectives To evaluate the contribution of long-term and short-term REM sleep homeostatic processes to REM sleep recovery and the ultradian organization of the sleep wake cycle. Methods Fifteen rats were sleep recorded under a 12:12 LD cycle. Animals were subjected during the rest phase to two protocols (2T2I or 2R2I) performed separately in non-consecutive experimental days. 2T2I consisted of 2 h of total sleep deprivation (TSD) followed immediately by 2 h of intermittent REM sleep deprivation (IRD). 2R2I consisted of 2 h of selective REM sleep deprivation (RSD) followed by 2 h of IRD. IRD was composed of four cycles of 20-min RSD intervals alternating with 10 min of sleep permission windows. Results REM sleep debt that accumulated during deprivation (9.0 and 10.8 min for RSD and TSD, respectively) was fully compensated regardless of cumulated NREM sleep or wakefulness during deprivation. Protocol 2T2I exhibited a delayed REM sleep rebound with respect to 2R2I due to a reduction of REM sleep transitions related to enhanced NREM sleep delta-EEG activity, without affecting REM sleep consolidation. Within IRD permission windows there was a transient and duration-dependent diminution of REM sleep transitions. Conclusions REM sleep recovery in the rat seems to depend on a long-term hourglass process activated by REM sleep absence. Both REM sleep transition probability and REM sleep episode consolidation depend on the long-term REM sleep hourglass. REM sleep activates a short-term REM sleep refractory period that modulates the ultradian organization of sleep states.

I. Time course of interventions and recovery sleep

2002 ◽  
Vol 283 (2) ◽  
pp. R521-R526 ◽  
Author(s):  
Esther Werth ◽  
Kimberly A. Cote ◽  
Eva Gallmann ◽  
Alexander A. Borbély ◽  
Peter Achermann
Keyword(s):  
Sleep Deprivation ◽  
Rem Sleep ◽  
Time Course ◽  
Early Morning ◽  
Adult Males ◽  
Sleep Regulation ◽  
Rem Sleep Deprivation ◽  
Sleep Episode ◽  
Recovery Sleep ◽  
Sleep Propensity

Although repeated selective rapid eye movement (REM) sleep deprivation by awakenings during nighttime has shown that the number of sleep interruptions required to prevent REM sleep increases within and across consecutive nights, the underlying regulatory processes remained unspecified. To assess the role of circadian and homeostatic factors in REM sleep regulation, REM sleep was selectively deprived in healthy young adult males during a daytime sleep episode (7–15 h) after a night without sleep. Circadian REM sleep propensity is known to be high in the early morning. The number of interventions required to prevent REM sleep increased from the first to the third 2-h interval by a factor of two and then leveled off. Only a minor REM sleep rebound (11.6%) occurred in the following undisturbed recovery night. It is concluded that the limited rise of interventions during selective daytime REM sleep deprivation may be due to the declining circadian REM sleep propensity, which may partly offset the homeostatic drive and the sleep-dependent disinhibition of REM sleep.

Effects of short- and long-term REM sleep deprivation on sexual behavior in male rats

1996 ◽  
Vol 59 (2) ◽  
pp. 277-281 ◽  
Author(s):  
Javier Velasquez-Moctezuma ◽  
Emilio Domiguez alazar ◽  
Socorro Retana-Marguez
Keyword(s):  
Sexual Behavior ◽  
Sleep Deprivation ◽  
Rem Sleep ◽  
Male Rats ◽  
Rem Sleep Deprivation ◽  
Short And Long Term

scholarly journals Neurogenesis in the rat neonate's hippocampus with maternal short‐term REM sleep deprivation restores by royal jelly treatment

2021 ◽  
Author(s):  
Atena Khodaverdiloo ◽  
Mona Farhadi ◽  
Melikasadat Jameie ◽  
Seyed behnamedin Jameie ◽  
Vahid Pirhajati
Keyword(s):  
Sleep Deprivation ◽  
Rem Sleep ◽  
Royal Jelly ◽  
Short Term ◽  
Rem Sleep Deprivation

Differential effect of short-term REM sleep deprivation on NGF and BDNF protein levels in the rat brain

2000 ◽  
Vol 877 (2) ◽  
pp. 387-390 ◽  
Author(s):  
Hiroyoshi Sei ◽  
Daisuke Saitoh ◽  
Kei Yamamoto ◽  
Kyoji Morita ◽  
Yusuke Morita
Keyword(s):  
Sleep Deprivation ◽  
Rat Brain ◽  
Rem Sleep ◽  
Differential Effect ◽  
Short Term ◽  
Rem Sleep Deprivation ◽  
Protein Levels

Effects of selective sleep deprivation on ventilation during recovery sleep in normal humans

1992 ◽  
Vol 72 (1) ◽  
pp. 100-109 ◽  
Author(s):  
J. B. Neilly ◽  
N. B. Kribbs ◽  
G. Maislin ◽  
A. I. Pack
Keyword(s):  
Sleep Deprivation ◽  
Eye Movement ◽  
Rem Sleep ◽  
Minute Ventilation ◽  
Nrem Sleep ◽  
Rapid Eye Movement ◽  
Rem Sleep Deprivation ◽  
Sleep Period ◽  
Recovery Sleep ◽  
The Relationship

To assess the effects of selective sleep loss on ventilation during recovery sleep, we deprived 10 healthy young adult humans of rapid-eye-movement (REM) sleep for 48 h and compared ventilation measured during the recovery night with that measured during the baseline night. At a later date we repeated the study using awakenings during non-rapid-eye-movement (NREM) sleep at the same frequency as in REM sleep deprivation. Neither intervention produced significant changes in average minute ventilation during presleep wakefulness, NREM sleep, or the first REM sleep period. By contrast, both interventions resulted in an increased frequency of breaths, in which ventilation was reduced below the range for tonic REM sleep, and in an increased number of longer episodes, in which ventilation was reduced during the first REM sleep period on the recovery night. The changes after REM sleep deprivation were largely due to an increase in the duration of the REM sleep period with an increase in the total phasic activity and, to a lesser extent, to changes in the relationship between ventilatory components and phasic eye movements. The changes in ventilation after partial NREM sleep deprivation were associated with more pronounced changes in the relationship between specific ventilatory components and eye movement density, whereas no change was observed in the composition of the first REM sleep period. These findings demonstrate that sleep deprivation leads to changes in ventilation during subsequent REM sleep.

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