scholarly journals 0065 Initial Findings on Associations Between Sleep and Clinical Measures with Neural Activations Accompanying Fear Conditioning and Extinction in Trauma-Exposed Individuals

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A26-A27
Author(s):  
J Seo ◽  
K I Oliver ◽  
C Daffre ◽  
E F Pace-Schott
Keyword(s):  
Sleep Quality ◽  
Fear Conditioning ◽  
Sleep Onset ◽  
Anterior Cingulate ◽  
Salience Network ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Post Traumatic Stress ◽  
Selective Activation ◽  
Extinction Learning

Abstract Introduction We examined associations of sleep and hyperarousal with neural responses to a fear conditioning and extinction protocol in trauma-exposed individuals. We hypothesized, greater hyperarousal, poorer sleep quality and more nightmares would accompany greater activation of the salience network (associated with fear) and lesser activation of the prefrontal cortex (PFC; associated with fear regulation) throughout this protocol. Methods Persons exposed to trauma within the past 2 years (N=119, 43 with Post-traumatic stress disorder; PTSD) completed the PTSD Checklist-5 (PCL-5), two weeks of actigraphy and sleep/nightmare diaries, and a 2-day fear-conditioning and extinction protocol during fMRI. Hyperarousal items from PCL-5, sleep quality, and nightmare frequency were used to predict fMRI contrasts representing (1) initial activations to reinforced conditioned stimuli (CS+) during fear conditioning, (2) change in neural activation to CS+s across extinction learning, and, (3) after 24 hours (extinction recall), selective activation to an extinguished (CS+E) versus an un-extinguished CS+. Results During fear conditioning, hyperarousal was positively correlated with activation to the CS+ in the right lateral PFC, whereas nightmare frequency was negatively correlated with activations in bilateral orbitofrontal cortex (OFC). Across extinction learning, sleep onset latency (SOL) was negatively correlated with increased activation to CS+ in bilateral insular and dorsal and middle anterior cingulate cortices (salience regions). At extinction recall, nightmare frequency was negatively correlated with selective activation to the CS+E in the left insular cortex. Conclusion Except that fewer nightmares predicted greater OFC activation during fear conditioning, results did not support hypothesized relationships of hyperarousal, poor sleep and nightmares with increased salience network and decreased PFC activation to fear-related stimuli. Support Funding: R01MH109638

778 Poor Sleep Quality is Associated with Reduced Myelination in Patients with Psychotic Disorders

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A303-A303
Author(s):  
Cagri Yuksel ◽  
Xi Chen ◽  
Lauren Watford ◽  
Margaret Gardner ◽  
Kathryn Lewandowski ◽  
...  
Keyword(s):  
White Matter ◽  
Sleep Quality ◽  
Psychotic Disorders ◽  
Sleep Onset ◽  
Sleep Loss ◽  
Magnetization Transfer Ratio ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Healthy Controls ◽  
Poor Sleep Quality

Abstract Introduction Recent studies show that sleep favors oligodendrocyte proliferation and myelination, and sleep loss is associated with alterations in white matter structure and decreased myelination. Psychotic disorders are characterized by disrupted white matter integrity, and abnormal axon and myelin structure. Despite common sleep disturbances in these disorders, little is known about the relationship between sleep quality and white matter findings. A novel in vivo neuroimaging technique that combines diffusion tensor spectroscopy (DTS) and magnetization transfer ratio (MTR) allows separately examining the axon structure and glial function, and myelin content, respectively. Using this method, we examined the association of sleep quality with white matter biology in a sample of patients with psychotic disorders and matched healthy controls. Methods Participants included patients diagnosed with bipolar disorder with psychotic features (euthymic or depressed, n=12) and schizophrenia spectrum disorders (n=9), and age and sex matched healthy controls (n=20). DTS and MTR data was collected from the right prefrontal white matter at 4T. DTS measures included apparent diffusion coefficients of water, NAA, creatine and choline. Sleep quality was measured using Pittsburgh Sleep Quality Index (PSQI). Results PSQI total score was significantly higher in patients. and patient sample included a higher percentage of poor sleepers (PSQI total score>5). In patients, total PSQI score and sleep onset latency were significantly and negatively associated with MTR (F=6.9, p=0.02 and F=9.7, p=0.007, respectively). There was no difference in any DTS measures between groups. Conclusion Our preliminary results show that poor sleep quality is associated with decreased myelin content in the frontal lobe, in patients with psychotic disorders. This finding suggests that sleep loss may be a mediator of white matter alterations in psychosis. Support (if any) This work is supported by National Institute of Mental Health K23MH119322 to Cagri Yuksel

Abstract 037: History Of Weight Cycling Is Prospectively Associated With Shorter And Poorer Quality Sleep, And Higher Sleep Apnea Risk In Diverse Us Women: Results From The AHA Go Red For Women Strategically Focused Research Network

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Vivian Cao ◽  
Nour Makarem ◽  
Moorea Maguire ◽  
Ivan Samayoa ◽  
Huaqing Xi ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Sleep Onset ◽  
Research Network ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Weight Cycling ◽  
Onset Latency ◽  
Cross Sectional ◽  
History Of ◽  
Insomnia Severity

Introduction: Poor sleep and history of weight cycling (HWC) are associated with worse cardiovascular health, yet limited research has evaluated the association between HWC and poor sleep patterns. Hypothesis: We hypothesized that HWC would be associated with poor sleep in US women. Methods: The AHA Go Red for Women Strategically Focused Research Network cohort at Columbia University (n=506, mean age 37 ± 15.7y, 61% racial/ethnic minority) was used to evaluate cross-sectional associations of HWC and sleep characteristics at baseline, and prospective associations of HWC from baseline with sleep measures at 1-yr. HWC, defined as losing and gaining ≥ 10 lbs at least once (excluding pregnancy), and number of WC episodes were self-reported. Sleep duration, measures of sleep quality, insomnia severity, and obstructive sleep apnea (OSA) risk were assessed using the validated Pittsburgh Sleep Quality Index, Insomnia Severity Index, and Berlin questionnaire. Linear and logistic regression models, adjusted for age, race/ethnicity, education, health insurance status, pregnancy history, and menopausal status, were used to evaluate the relation of HWC with sleep. Results: Most women reported ≥1episode of weight cycling (72%). In linear models of cross-sectional and prospective data, each additional weight cycling episode was related to shorter sleep duration, poorer sleep quality, longer sleep onset latency, greater insomnia severity, more sleep disturbances and daytime dysfunction, lower sleep efficiency, and higher sleep medication use frequency. In logistic models, HWC (≥1 vs. 0 episodes) was associated with greater odds for short sleep, poor sleep quality, long sleep onset latency ≥26 min, high OSA risk, and sleep efficiency<85% ( Table ). Conclusion: HWC predicted poor sleep among women, suggesting that weight maintenance may represent an important strategy to promote sleep health. Long-term studies are needed to disentangle the complex relations between weight fluctuations and sleep across the life course.

scholarly journals The Impact of Sleep Timing, Sleep Duration, and Sleep Quality on Depressive Symptoms and Suicidal Ideation amongst Japanese Freshmen: The EQUSITE Study

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Atin Supartini ◽  
Takanori Honda ◽  
Nadzirah A. Basri ◽  
Yuka Haeuchi ◽  
Sanmei Chen ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Suicidal Ideation ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Sleep Onset ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Onset Latency ◽  
Poor Sleep Quality ◽  
The Impact

Aim. The aim of this study was to identify the impact of bedtime, wake time, sleep duration, sleep-onset latency, and sleep quality on depressive symptoms and suicidal ideation amongst Japanese freshmen.Methods. This cross-sectional data was derived from the baseline survey of the Enhancement of Q-University Students Intelligence (EQUSITE) study conducted from May to June, 2010. A total of 2,631 participants were recruited and completed the following self-reported questionnaires: the Pittsburgh Sleep Quality Index (PSQI), the Center for Epidemiologic Studies Depression Scale (CES-D), and the original Health Support Questionnaires developed by the EQUSITE study research team.Results. Of 1,992 participants eligible for analysis, 25.5% (n=507) reported depressive symptoms (CES-D total score ≥ 16), and 5.8% (n=115) reported suicidal ideation. The present study showed that late bedtime (later than 01:30), sleep-onset latency (≥30 minutes), and poor sleep quality showed a marginally significant association with depressive symptoms. Poor sleep quality was seen to predict suicidal ideation even after adjusting for depressive symptoms.Conclusion. The current study has important implications for the role of bedtime in the prevention of depressive symptoms. Improving sleep quality may prevent the development of depressive symptoms and reduce the likelihood of suicidal ideation.

scholarly journals What type of mattress should be chosen to avoid back pain and improve sleep quality? Review of the literature

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Gianfilippo Caggiari ◽  
Giuseppe Rocco Talesa ◽  
Giuseppe Toro ◽  
Eugenio Jannelli ◽  
Gaetano Monteleone ◽  
...  
Keyword(s):  
Systematic Review ◽  
Low Back Pain ◽  
Back Pain ◽  
Sleep Quality ◽  
Sleep Disturbances ◽  
Meta Analysis ◽  
Sleep Onset ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Low Back

AbstractEnergy spent during daily activities is recuperated by humans through sleep, ensuring optimal performance on the following day. Sleep disturbances are common: a meta-analysis on sleep quality showed that 15–30% of adults report sleep disorders, such as sleep onset latency (SOL), insufficient duration of sleep and frequently waking up at night. Low back pain (LBP) has been identified as one of the main causes of poor sleep quality. Literature findings are discordant on the type of mattress that might prevent onset of back pain, resulting in an improved quality of sleep. We conducted a systematic literature review of articles published until 2019, investigating the association of different mattresses with sleep quality and low back pain. Based on examined studies, mattresses were classified according to the European Committee for Standardization (2000) as: soft, medium-firm, extra-firm or mattresses customized for patients affected by supine decubitus. A total of 39 qualified articles have been included in the current systematic review. Results of this systematic review show that a medium-firm mattress promotes comfort, sleep quality and rachis alignment.

scholarly journals Considering Sleep, Mood, and Stress in a Family Context: A Preliminary Study

2019 ◽  
Vol 1 (2) ◽  
pp. 259-272 ◽  
Author(s):  
Valeria Bacaro ◽  
Bernd Feige ◽  
Andrea Ballesio ◽  
Paola De Bartolo ◽  
Anna F. Johann ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Gender Gap ◽  
Negative Mood ◽  
Family Members ◽  
Sleep Onset ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Mothers And Fathers ◽  
Sleep Diaries ◽  
Lack Of Sleep

Background: During the first years of life, parental sleep strongly depends on child’s sleep quality. Poor parental sleep may relate to increased stress and negative mood. However, there is a lack of sleep studies focusing on all family members. This study aimed to investigate the relationship between sleep, mood, and stress in mothers, fathers and children. Methods: Data were obtained from 65 parental couples and 65 children (2 to 36 months). Data on sleep for all family members and stress of parents were completed by both mothers and fathers through questionnaires and sleep diaries. Results: Toddlers’ positive mood before nocturnal sleep was significantly associated with reduced wake times after sleep onset. Mothers reported worse sleep quality compared to fathers. Shorter sleep onset latency in fathers and better sleep efficiency in mothers were linked with better self-reported mood upon awakening. In mothers, but not in fathers, poor sleep quality was associated with higher perceived stress. Conclusion: Results suggest bidirectional relationships between sleep and mood in children, mothers and fathers. Moreover, results evidence poorer sleep in mothers, compared to fathers, which was linked with increased parenting stress. This gender gap should be further considered in studies with larger samples and in clinical contexts.

scholarly journals Occupational stress and quality of sleep among dentists in the Philippines

2021 ◽  
Author(s):  
Junhel Dalanon ◽  
Ivy Fernandez ◽  
Cora Estalani ◽  
Sachiko Chikahisa ◽  
Noriyuki Shimizu ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Occupational Stress ◽  
Sleep Onset ◽  
The Philippines ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Self Assessment ◽  
Bidirectional Relationship ◽  
Low Prevalence

ABSTRACTBackgroundOccupational stress and sleep quality share a bidirectional relationship among other comorbidities. Dentistry remains among the health professions that suffer the greatest stress.AimThis study aimed to evaluate the correlation between occupational stress and sleep quality among dentists in the Philippines.MethodsThe Caregiver Self-Assessment Questionnaire assessed occupational stress and the Pittsburgh Sleep Quality Index measured sleep quality in purposively sampled dentists (n=420) in the Philippines.ResultsThe prevalence of occupational stress (19%) was low yet poor sleep quality (71%) was high. The global PSQI score (p=0.047) and sleep onset latency (p=0.036) were found to be associated with occupational stress.ConclusionsThis study supports the vast literature on the relationship between occupational stress and sleep quality, despite documenting an unexpected low prevalence of occupational stress in Filipino dentists. Further research on the coping mechanisms of these dentists is warranted.

scholarly journals Sleep quality and athletic performance according to chronotype

2020 ◽  
Author(s):  
Seung-Taek Lim ◽  
Do-Yoon Kim ◽  
Hyeong-Tae Kwon ◽  
Eunjae Lee
Keyword(s):  
Sleep Quality ◽  
Athletic Performance ◽  
Peak Power ◽  
Elite Athletes ◽  
Sleep Onset ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Early Type ◽  
Late Type ◽  
Mean Power

Abstract Background: When studying the quality of sleep in relation to athletic performance, the athlete's chronotype and habitual time consider important factors. We aim to investigate the sleep quality and athletes’ performance according to chronotype in elite athletes. Methods: Three hundred forty elite athletes (males = 261, females = 79) were recruited for the present study. All participants were screening for chronotype by the Korean versions of the Morningness - Eveningness Questionnaire (MEQ-K). The Pittsburgh Sleep Quality Index (PSQI) and Wingate Anaerobic Test (WAnT) were measurement after screening.Results: PSQI global score, PSQI sleep quality, PSQI sleep onset latency, PSQI sleep disturbance, and PSQI daytime dysfunction were significant differences among the groups. WAnT mean power (W), mean power (W/kg), peak power (W), and peak power (W/kg) were significant differences among the groups. A negative correlation coefficient was found between PSQI score and WAnT mean power (W), mean power (W/kg), peak power (W), and peak power (W/kg).Conclusions: This study indicates that related poor sleep quality and late-type chronotype may reduce the athletes’ performance in elite athletes. In addition, the sleep quality is much better in the early-type chronotype than in the late-type chronotype. Moreover, it also the athletic performance was better in the early-type chronotype than in the late-type chronotype.

Actigraphy assessment of sleep quality among patients with acute myeloid leukaemia during induction chemotherapy

2018 ◽  
Vol 8 (3) ◽  
pp. 274-277 ◽  
Author(s):  
Chi-Fu Jeffrey Yang ◽  
Kelli Aibel ◽  
Ryan Meyerhoff ◽  
Frances Wang ◽  
David Harpole ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Sleep Quality ◽  
Myeloid Leukaemia ◽  
Induction Chemotherapy ◽  
Sleep Onset ◽  
Sleep Efficiency ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Onset Latency ◽  
Acute Myeloid

ObjectivesPatients receiving induction chemotherapy for acute myeloid leukaemia (AML) anecdotally describe poor sleep, but sleep disturbances have not been well-characterised in this population. We aimed to test the feasibility of measuring sleep quality in AML inpatients using a wearable actigraphy device.MethodsUsing the Actigraph GT3X ‘watch’, we assessed the total sleep time, sleep onset latency, wake after sleep onset, number of awakenings after sleep onset and sleep efficiency for inpatients with AML receiving induction chemotherapy. We assessed patient self-reported sleep quality using the Pittsburgh Sleep Quality Index (PSQI).ResultsOf the 12 patients enrolled, 11 completed all actigraphy and PSQI assessments, demonstrating feasibility. Patients wore the Actigraph device for a mean (SD) of 15.92 (8.3) days, and actigraphy measures suggested poor sleep. Patients had a median average awakening length of 6.92 min, a median number of awakenings after sleep onset of 4 and a median sleep onset latency of 10.8 min. Actual median sleep efficiency (0.91) was high, suggesting that patients’ poor sleep was not due to insomnia but perhaps due to interruptions, such as administration of medications, lab draws and vital sign measurements.ConclusionsCollection of sleep quality data among inpatients with AML via a wearable actigraphy device is feasible. AML inpatients appear to have poor sleep quality and quantity, suggesting that sleep issues represent an area of unmet supportive care needs in AML. Further research in this areas is needed to inform the development of interventions to improve sleep duration and quality in hospitalised patients with AML.

scholarly journals Sleep Quality and Athletic Performance According to Chronotype

2020 ◽  
Author(s):  
Seung-Taek Lim ◽  
Do-Yoon Kim ◽  
Hyeong-Tae Kwon ◽  
Eunjae Lee
Keyword(s):  
Sleep Quality ◽  
Athletic Performance ◽  
Peak Power ◽  
Elite Athletes ◽  
Sleep Onset ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Early Type ◽  
Late Type ◽  
Mean Power

Abstract Background: When studying the quality of sleep in relation to athletic performance, the athlete's chronotype and habitual time were considered important factors. We aimed to investigate the sleep quality and athletes’ performance according to chronotype in elite athletes. Methods: Three hundred forty elite athletes (males = 261, females = 79) were recruited for the present study. All participants were screened for chronotype. Measurements of the Korean versions of the Morningness - Eveningness Questionnaire (MEQ-K), Pittsburgh Sleep Quality Index (PSQI), and Wingate Anaerobic Test (WAnT). Results: PSQI global score, PSQI sleep quality, PSQI sleep onset latency, PSQI sleep disturbance, and PSQI daytime dysfunction were significantly difference in among the groups. Mean power, and peak power were significantly difference in among the groups. A negative correlation was found between PSQI score and mean power (W), mean power (W/kg), peak power (W), and peak power (W/kg). Conclusions: This study indicates that related poor sleep quality and late type of chronotype may reduce the athletes’ performance in elite athletes. In additional, significant better sleep quality in early type of chronotype more than late type of chronotype. Moreover, also significant higher athletic performance in early type of chronotype more than late type of chronotype.

scholarly journals Sleep quality and athletic performance according to chronotype

2020 ◽  
Author(s):  
Seung-Taek Lim ◽  
Do-Yoon Kim ◽  
Hyeong-Tae Kwon ◽  
Eunjae Lee
Keyword(s):  
Sleep Quality ◽  
Athletic Performance ◽  
Peak Power ◽  
Elite Athletes ◽  
Sleep Onset ◽  
Poor Sleep ◽  
Sleep Onset Latency ◽  
Early Type ◽  
Late Type ◽  
Mean Power

Abstract Background: When studying the quality of sleep in relation to athletic performance, the athlete's chronotype and habitual time consider important factors. We aim to investigate the sleep quality and athletes’ performance according to chronotype in elite athletes.Methods: Three hundred forty elite athletes (males = 261, females = 79) were recruited for the present study. All participants were screening for chronotype by the Korean versions of the Morningness - Eveningness Questionnaire (MEQ-K). The Pittsburgh Sleep Quality Index (PSQI) and Wingate Anaerobic Test (WAnT) were measurement after screening.Results: PSQI global score, PSQI sleep quality, PSQI sleep onset latency, PSQI sleep disturbance, and PSQI daytime dysfunction were significant differences among the groups. WAnT mean power (W), mean power (W/kg), peak power (W), and peak power (W/kg) were significant differences among the groups. A negative correlation coefficient was found between PSQI score and WAnT mean power (W) (r= -0.256, p <0.01), mean power (W/kg) (r= -0.270, p <0.01), peak power (W) (r= -0.220, p <0.01), and peak power (W/kg) (r= -0.248, p <0.01).Conclusions: This study indicates that related poor sleep quality and late-type chronotype may reduce the athletes’ performance in elite athletes. In addition, the sleep quality is much higher in the early-type chronotype than in the late-type chronotype. Moreover, it also the athletic performance was better in the early-type chronotype than in the late-type chronotype.

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