scholarly journals Differential Effects of Polychlorinated Biphenyl Congeners on Serum Thyroid Hormone Levels in Rats

2010 ◽  
Vol 117 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Lori Martin ◽  
Curtis D. Klaassen
Kanzo ◽  
1978 ◽  
Vol 19 (1) ◽  
pp. 67-74
Author(s):  
Kenichi KITANI ◽  
Masahiko IUCHI ◽  
Kyoko SHIBATA

2012 ◽  
Vol 97 (9) ◽  
pp. 3170-3178 ◽  
Author(s):  
Annemieke J. Lem ◽  
Yolanda B. de Rijke ◽  
Hans van Toor ◽  
Maria A. J. de Ridder ◽  
Theo J. Visser ◽  
...  

Critical Care ◽  
2013 ◽  
Vol 17 (S3) ◽  
Author(s):  
J Vidart ◽  
SM Wajner ◽  
BD Schaan ◽  
AL Maia

Author(s):  
Salih Saygin Eker ◽  
Cengiz Akkaya ◽  
Asli Sarandol ◽  
Sengul Cangur ◽  
Emre Sarandol ◽  
...  

1983 ◽  
Vol 29 (10) ◽  
pp. 1866-1867 ◽  
Author(s):  
F L Van de Vyver ◽  
J Kruse ◽  
L Muylle ◽  
O Bouque ◽  
P P Blockx

2005 ◽  
Vol 90 (12) ◽  
pp. 6498-6507 ◽  
Author(s):  
Robin P. Peeters ◽  
Serge van der Geyten ◽  
Pieter J. Wouters ◽  
Veerle M. Darras ◽  
Hans van Toor ◽  
...  

Context: Pronounced alterations in serum thyroid hormone levels occur during critical illness. T3 decreases and rT3 increases, the magnitudes of which are related to the severity of disease. It is unclear whether these changes are associated with decreased tissue T3 concentrations and, thus, reduced thyroid hormone bioactivity. Patients and Study Questions: We therefore investigated, in 79 patients who died after intensive care and who did or did not receive thyroid hormone treatment, whether total serum thyroid hormone levels correspond to tissue levels in liver and muscle. Furthermore, we investigated the relationship between tissue thyroid hormone levels, deiodinase activities, and monocarboxylate transporter 8 expression. Results: Tissue iodothyronine levels were positively correlated with serum levels, indicating that the decrease in serum T3 during illness is associated with decreased levels of tissue T3. Higher serum T3 levels in patients who received thyroid hormone treatment were accompanied by higher levels of liver and muscle T3, with evidence for tissue-specific regulation. Tissue rT3 and the T3/rT3 ratio were correlated with tissue deiodinase activities. Monocarboxylate transporter 8 expression was not related to the ratio of the serum over tissue concentration of the different iodothyronines. Conclusion: Our results suggest that, in addition to changes in the hypothalamus-pituitary-thyroid axis, tissue-specific mechanisms are involved in the reduced supply of bioactive thyroid hormone in critical illness.


1985 ◽  
Vol 24 (5) ◽  
pp. 509-517 ◽  
Author(s):  
I.J. Sharma ◽  
S.P. Agarwal ◽  
V.K. Agarwal ◽  
P.K. Dwaraknath

1986 ◽  
Vol 30 (1) ◽  
pp. 71-78 ◽  
Author(s):  
K. Rozman ◽  
J.R. Gorski ◽  
P. Rozman ◽  
A. Parkinson

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