scholarly journals Modulation of PC12 Cell Viability by Forskolin-Induced Cyclic AMP Levels Through ERK and JNK Pathways: An Implication for L-DOPA-Induced Cytotoxicity in Nigrostriatal Dopamine Neurons

2012 ◽  
Vol 128 (1) ◽  
pp. 247-257 ◽  
Author(s):  
K. H. Park ◽  
H. J. Park ◽  
K. S. Shin ◽  
H. S. Choi ◽  
M. Kai ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Cell Viability ◽  
Pc12 Cell ◽  
Dopamine Neurons ◽  
Nigrostriatal Dopamine ◽  
Nigrostriatal Dopamine Neurons

scholarly journals Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson’s Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Rayul Wi ◽  
Young Cheul Chung ◽  
Byung Kwan Jin ◽  
Lihua Duan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Significant Loss ◽  
Glial Activation ◽  
Dopamine Neurons ◽  
Pcr Analysis ◽  
Beneficial Effects ◽  
Nigrostriatal Dopamine ◽  
Nigrostriatal Dopamine Neurons

The present study examined whether crosstalk between cannabinoid (CB) and transient potential receptor vanilloid type 1 (TRPV1) could contribute to the survival of nigrostriatal dopamine neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD). MPTP induced a significant loss of nigrostriatal dopamine neurons and glial activation in the substantia nigra (SN) and striatum (STR) as visualized by tyrosine hydroxylase (TH) or macrophage antigen complex-1 (MAC-1) or glial fibrillary acidic protein (GFAP) immunocytochemistry, respectively. RT-PCR analysis shows the upregulation of inducible nitric oxide synthase, interleukin-1β, and tumor necrosis factor-α in microglia in the SN in vivo, indicating the activation of the inflammatory system. By contrast, treatment with capsaicin (a specific TRPV1 agonist) increased the survival of dopamine neurons in the SN and their fibers and dopamine levels in the STR in MPTP mice. Capsaicin neuroprotection is accompanied by inhibiting MPTP-induced glial activation and production of inflammatory cytokines. Treatment with AM251 and AM630 (CB1/2 antagonists) abolished capsaicin-induced beneficial effects, indicating the existence of a functional crosstalk between CB and TRPV1. Moreover, treatment with anandamide (an endogenous agonist for both CB and TRVP1) rescued nigrostriatal dopamine neurons and reduced gliosis-derived neuroinflammatory responses in MPTP mice. These results suggest that the cannabinoid and vanilloid system may be beneficial for the treatment of neurodegenerative diseases, such as PD, that are associated with neuroinflammation.

Reciprocal influences of activating and immobilizing stimuli on the activity of nigrostriatal dopamine neurons

1979 ◽  
Vol 176 (2) ◽  
pp. 385-390 ◽  
Author(s):  
Louis A. Chiodo ◽  
Anthony R. Caggiula ◽  
Seymour M. Antelman ◽  
Charles G. Lineberry
Keyword(s):  
Dopamine Neurons ◽  
Nigrostriatal Dopamine ◽  
Nigrostriatal Dopamine Neurons ◽  
Reciprocal Influences

scholarly journals 9-Cis Retinoic Acid Protects Against Methamphetamine-Induced Neurotoxicity in Nigrostriatal Dopamine Neurons

2013 ◽  
Vol 25 (3) ◽  
pp. 248-261 ◽  
Author(s):  
David J. Reiner ◽  
Seong-Jin Yu ◽  
Hui Shen ◽  
Yi He ◽  
Eunkyung Bae ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Dopamine Neurons ◽  
Nigrostriatal Dopamine ◽  
Nigrostriatal Dopamine Neurons
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