scholarly journals Selection of the Dominant Follicle in Cattle: Role of Two-Way Functional Coupling Between Follicle-Stimulating Hormone and the Follicles1

2000 ◽  
Vol 62 (4) ◽  
pp. 920-927 ◽  
Author(s):  
O.J. Ginther ◽  
D.R. Bergfelt ◽  
L.J. Kulick ◽  
K. Kot
1991 ◽  
Vol 125 (3) ◽  
pp. 280-285 ◽  
Author(s):  
J. Alan Talbot ◽  
Ann Lambert ◽  
Robert Mitchell ◽  
Marek Grabinski ◽  
David C. Anderson ◽  
...  

Abstract We have investigated the role of Ca2+ in the control of FSH-induced estradiol secretion by Sertoli cells isolated from 8-10 days old rats. Exogenous Ca2+ (4-8 mmol/1) inhibited FSH-stimulated E2 secretion such that, with 8 mmol/l Ca2+ and FSH (8 IU/l) E2 secretion decreased from 2091±322 to 1480±84 pmol/l (p<0.002), whilst chelation of Ca2+ in the culture medium with EGTA (3 mmol/l) increased E2 secretion from 360±45 to 1242±133 pmol/l) in the absence of FSH. Further, EGTA (3 mmol/l) markedly potentiated FSH (8 IU/l), forskolin (1 μmol/l) and dibutyryl cAMP (1 mmol/l)-stimulated E2 secretion. Addition of the Ca2+ ionophores, ionomycin (2-5 μmol/l) and A23187 (2 μmol/l), inhibited FSH (8 IU/l)-stimulated E2 secretion by >80%. The effect of ionomycin was totally reversible, whereas that of A23187 was irreversible. Ionomycin (5 μmol/l) had no effect on EGTA-induced E2 secretion in the absence of FSH, but reduced EGTA-provoked E2 secretion by 59% in the presence of FSH (8 IU/l). Similarly, forskolin- and dibutyryl cAMP-provoked E2 production was inhibited 46-50% by ionomycin (5 μmol/l). We conclude that FSH-induced E2 secretion from immature rat Sertoli cells is modulated by intra- and extracellular Ca2+.


2008 ◽  
Vol 70 (2) ◽  
pp. 266-272 ◽  
Author(s):  
Richard J. Kline ◽  
Izhar A. Khan ◽  
Kiyoshi Soyano ◽  
Megumi Takushima

Author(s):  
Ravi Kant ◽  
Mahendra Kumar Meena

Kisspeptin or GPR-54 is a product of KISS 1 gene regulating the production of gonadotropin releasing hormone (GnRH), luteinizing (LH) as well follicle stimulating hormone (FSH). Both LH and FSH are important hormones for reproduction in animals as well in humans. The recognition of Kisspeptin has a landmark bearing in reproductive biology. Few recent pilot studies have convincingly proven it to be a promising molecule in treating infertile couples especially those having hypogonadotropic hypogonadism not responding to conventional treatment.


1996 ◽  
Vol 271 (52) ◽  
pp. 33317-33324 ◽  
Author(s):  
Tamara L. Goetz ◽  
Tracy L. Lloyd ◽  
Michael D. Griswold

2013 ◽  
Vol 12 (3) ◽  
pp. 2945-2952 ◽  
Author(s):  
X.L. Zhou ◽  
Y. Teng ◽  
R. Cao ◽  
H. Fu ◽  
K. Xiong ◽  
...  

Endocrine ◽  
1999 ◽  
Vol 11 (3) ◽  
pp. 205-216 ◽  
Author(s):  
Alfredo Ulloa-Aguirre ◽  
Carlos Timossi ◽  
Pablo Damián-Matsumura ◽  
James A. Dias

1997 ◽  
Vol 57 (6) ◽  
pp. 1320-1327 ◽  
Author(s):  
E. L. Gastal ◽  
M. O. Gastal ◽  
D. R. Bergfelt ◽  
O. J. Ginther

Sign in / Sign up

Export Citation Format

Share Document