Plasma phospholipid transfer protein prevents vascular endothelium dysfunction by delivering α‐tocopherol to endothelial cells

1999 ◽  
Vol 13 (8) ◽  
pp. 883-892 ◽  
Author(s):  
Catherine Desrumaux ◽  
Valérie Deckert ◽  
Anne Athias ◽  
David Masson ◽  
Gérard Lizard ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelium ◽  
Plasma Phospholipid ◽  
Phospholipid Transfer Protein ◽  
Endothelium Dysfunction ◽  
Transfer Protein ◽  
Phospholipid Transfer

scholarly journals Biosynthesis and secretion of human plasma phospholipid transfer protein

1998 ◽  
Vol 39 (10) ◽  
pp. 2021-2030 ◽  
Author(s):  
Jarkko Huuskonen ◽  
Matti Jauhiainen ◽  
Christian Ehnholm ◽  
Vesa M. Olkkonen
Keyword(s):  
Human Plasma ◽  
Plasma Phospholipid ◽  
Phospholipid Transfer Protein ◽  
Transfer Protein ◽  
Phospholipid Transfer

New therapeutic horizons for plasma phospholipid transfer protein (PLTP): Targeting endotoxemia, infection and sepsis

2021 ◽  
pp. 108105
Author(s):  
Thomas Gautier ◽  
Valérie Deckert ◽  
Maxime Nguyen ◽  
Catherine Desrumaux ◽  
David Masson ◽  
...  
Keyword(s):  
Plasma Phospholipid ◽  
Phospholipid Transfer Protein ◽  
Transfer Protein ◽  
Phospholipid Transfer

Pig plasma phospholipid transfer protein releases apo A-I from HDL, causing HDL interconversion

1994 ◽  
Vol 109 (1-2) ◽  
pp. 236
Author(s):  
P. Pussinen ◽  
M. Jauhiainen ◽  
J. Metso ◽  
C. Ehnholm
Keyword(s):  
Plasma Phospholipid ◽  
Phospholipid Transfer Protein ◽  
Transfer Protein ◽  
Phospholipid Transfer

scholarly journals Measurement of Human Plasma Phospholipid Transfer Protein by Sandwich ELISA

2000 ◽  
Vol 46 (9) ◽  
pp. 1357-1364 ◽  
Author(s):  
Tomoichiro Oka ◽  
Takeshi Kujiraoka ◽  
Mayumi Ito ◽  
Makoto Nagano ◽  
Mitsuaki Ishihara ◽  
...  
Keyword(s):  
Chinese Hamster Ovary Cells ◽  
Sandwich Elisa ◽  
Chinese Hamster ◽  
Plasma Phospholipid ◽  
Hdl Cholesterol ◽  
Phospholipid Transfer Protein ◽  
Ovary Cells ◽  
Transfer Protein ◽  
Phospholipid Transfer ◽  
Hdl2 Cholesterol

Abstract Background: Plasma phospholipid transfer protein (PLTP) plays a central role in the remodeling of HDLs. Reliable and accurate methods for assaying PLTP concentration are required. Methods: A sandwich ELISA for PLTP has been developed, using two monoclonal antibodies against recombinant human PLTP (rhPLTP) expressed in Chinese hamster ovary cells. The ELISA allows for the quantification of PLTP in the range 0.625–15.0 ng/assay (1.2–30.0 mg/L). Intra- and interassay CVs were <3.0% and <4.2% respectively. The assay was used to quantify plasma PLTP concentrations in 132 Japanese subjects (75 males and 57 females). Results: PLTP concentrations were 12.0 ± 3.0 mg/L (mean ± SD; range, 4.9–20.5 mg/L). No sex difference was observed. Plasma PLTP concentration was positively correlated with HDL-cholesterol (r = 0.72; P <0.001), apolipoprotein (apo) A-I (r = 0.62; P <0.001) and HDL2-cholesterol (r = 0.72; P <0.001), and was negatively correlated with triacylglycerol (r = −0.45; P <0.001). There was no correlation with plasma apo A-II. These results agree with other evidence that plasma PLTP is associated with large apo A-I-containing lipoproteins. There was no correlation (r = −0.01) between plasma PLTP and plasma phosphatidylcholine transfer activity (range, 3.5–10.5 μmol · mL−1 · h−1), suggesting that PLTP may exist in active and inactive forms. Conclusion: This new ELISA will be of value for further studies of PLTP in health and disease.

scholarly journals Plasma Phospholipid Transfer Protein Deficiency in Mice Is Associated With a Reduced Thrombotic Response to Acute Intravascular Oxidative Stress

2010 ◽  
Vol 30 (12) ◽  
pp. 2452-2457 ◽  
Author(s):  
Catherine Desrumaux ◽  
Valérie Deckert ◽  
Stéphanie Lemaire-Ewing ◽  
Claude Mossiat ◽  
Anne Athias ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Plasma Phospholipid ◽  
Protein Deficiency ◽  
Phospholipid Transfer Protein ◽  
Transfer Protein ◽  
Phospholipid Transfer
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