scholarly journals The Loss of Endogenous Neuregulin‐4 Increases Intestinal Epithelial Permeability and Apoptosis

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Jessica Kathleen Bernard ◽  
Michael A Schumacher ◽  
Mark R Frey
Keyword(s):  
Intestinal Epithelial ◽  
Epithelial Permeability ◽  
Neuregulin 4

T1270 Gliadin Induced Increase in Intestinal Epithelial Permeability Is Independent of MEK

2008 ◽  
Vol 134 (4) ◽  
pp. A-520
Author(s):  
Alex Staudacher ◽  
Barry C. Powell ◽  
Guy R. Sander
Keyword(s):  
Intestinal Epithelial ◽  
Epithelial Permeability

The role of caspase-3 in lipopolysaccharide-mediated disruption of intestinal epithelial tight junctions

2006 ◽  
Vol 84 (10) ◽  
pp. 1043-1050 ◽  
Author(s):  
Alex C. Chin ◽  
Andrew N. Flynn ◽  
Jason P. Fedwick ◽  
Andre G. Buret
Keyword(s):  
Escherichia Coli ◽  
Tight Junctions ◽  
Intestinal Permeability ◽  
Barrier Function ◽  
Caspase 3 ◽  
Parp Cleavage ◽  
Intestinal Epithelial ◽  
Epithelial Permeability ◽  
Epithelial Monolayers

The mechanisms responsible for microbially induced epithelial apoptosis and increased intestinal permeability remain unclear. This study assessed whether purified bacterial lipopolysaccharide (LPS) increases epithelial apoptosis and permeability and whether these changes are dependent on caspase-3 activation. In nontumorigenic epithelial monolayers, Escherichia coli O26:B6 LPS increased apoptosis, as shown by nuclear breakdown, caspase-3 activation, and PARP cleavage, and induced disruption of tight junctional ZO-1. Apical, but not basolateral, exposure to LPS increased epithelial permeability. Addition of a caspase-3 inhibitor abolished the effects of LPS. The findings describe a novel mechanism whereby apical LPS may disrupt epithelial tight junctional ZO-1 and barrier function in a caspase-3-dependent fashion.

scholarly journals Modulation of Intestinal Epithelial Permeability in Differentiated Caco-2 Cells Exposed to Aflatoxin M1 and Ochratoxin A Individually or Collectively

Toxins ◽  
2017 ◽  
Vol 10 (1) ◽  
pp. 13 ◽  
Author(s):  
Yanan Gao ◽  
Songli Li ◽  
Jiaqi Wang ◽  
Chaochao Luo ◽  
Shengguo Zhao ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Aflatoxin M1 ◽  
Intestinal Epithelial ◽  
Epithelial Permeability

scholarly journals Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

Immunity ◽  
2015 ◽  
Vol 43 (4) ◽  
pp. 727-738 ◽  
Author(s):  
Jacob S. Lee ◽  
Cristina M. Tato ◽  
Barbara Joyce-Shaikh ◽  
Muhammet F. Gulen ◽  
Corinne Cayatte ◽  
...  
Keyword(s):  
Intestinal Epithelial ◽  
Epithelial Permeability ◽  
Interleukin 23
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