scholarly journals Recovery of respiratory motor function after repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin (1178.8)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Jason Mateika ◽  
Chelsea Richardson ◽  
Julia Solarewicz ◽  
Mariana Angoa‐Perez ◽  
Kwaku Nantwi ◽  
...  
Keyword(s):  
Motor Function ◽  
Intermittent Hypoxia ◽  
Repeated Exposure ◽  
Brain Serotonin

Exposure to Acute Intermittent Hypoxia Augments Somatic Motor Function in Humans With Incomplete Spinal Cord Injury

2011 ◽  
Vol 26 (2) ◽  
pp. 163-172 ◽  
Author(s):  
Randy D. Trumbower ◽  
Arun Jayaraman ◽  
Gordon S. Mitchell ◽  
William Z. Rymer
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Function ◽  
Intermittent Hypoxia ◽  
Incomplete Spinal Cord Injury ◽  
Cord Injury

scholarly journals Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment: A pilot study

2016 ◽  
Vol 40 (3) ◽  
pp. 295-303 ◽  
Author(s):  
Meaghan Lynch ◽  
Lynsey Duffell ◽  
Milap Sandhu ◽  
Sudarshan Srivatsan ◽  
Kelly Deatsch ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pilot Study ◽  
Motor Function ◽  
Intermittent Hypoxia ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

scholarly journals Unexpected Benefits of Intermittent Hypoxia: Enhanced Respiratory and Nonrespiratory Motor Function

Physiology ◽  
2014 ◽  
Vol 29 (1) ◽  
pp. 39-48 ◽  
Author(s):  
E. A. Dale ◽  
F. Ben Mabrouk ◽  
G. S. Mitchell
Keyword(s):  
Nervous System ◽  
Motor Function ◽  
Intermittent Hypoxia ◽  
Low Dose ◽  
Spinal Injury ◽  
Trophic Factors ◽  
Systemic Hypertension ◽  
Cellular Mechanisms ◽  
Clinical Disorders ◽  
Respiratory Plasticity

Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-disordered breathing, including central nervous system pathology. However, recent evidence suggests that the nervous system fights back in an attempt to minimize pathology by increasing the expression of growth/trophic factors that confer neuroprotection and neuroplasticity. For example, even modest (“low dose”) IH elicits respiratory motor plasticity, increasing the strength of respiratory contractions and breathing. These low IH doses upregulate hypoxia-sensitive growth/trophic factors within respiratory motoneurons but do not elicit detectable pathologies such as hippocampal cell death, neuroinflammation, or systemic hypertension. Recent advances have been made toward understanding cellular mechanisms giving rise to IH-induced respiratory plasticity, and attempts have been made to harness the benefits of low-dose IH to treat respiratory insufficiency after cervical spinal injury. Our recent realization that IH also upregulates growth/trophic factors in nonrespiratory motoneurons and improves limb (or leg) function after incomplete chronic spinal injuries suggests that IH-induced plasticity is a general feature of motor systems. Collectively, available evidence suggests that low-dose IH may represent a safe and effective treatment to restore lost motor function in diverse clinical disorders that impair motor function.

scholarly journals Intermittent hypoxia promotes recovery of respiratory motor function in spinal cord-injured mice depleted of serotonin in the central nervous system

2016 ◽  
Vol 121 (2) ◽  
pp. 545-557 ◽  
Author(s):  
Dragana Komnenov ◽  
Julia Z. Solarewicz ◽  
Fareeza Afzal ◽  
Kwaku D. Nantwi ◽  
Donald M. Kuhn ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Motor Function ◽  
Intermittent Hypoxia ◽  
Partial Recovery ◽  
Breathing Frequency ◽  
Cord Injury ◽  
The Central Nervous System ◽  
Diaphragm Activity

We examined the effect of repeated daily exposure to intermittent hypoxia (IH) on the recovery of respiratory and limb motor function in mice genetically depleted of central nervous system serotonin. Electroencephalography, diaphragm activity, ventilation, core body temperature, and limb mobility were measured in spontaneously breathing wild-type (Tph2+/+) and tryptophan hydroxylase 2 knockout (Tph2−/−) mice. Following a C2 hemisection, the mice were exposed daily to IH (i.e., twelve 4-min episodes of 10% oxygen interspersed with 4-min normoxic periods followed by a 90-min end-recovery period) or normoxia (i.e., sham protocol, 21% oxygen) for 10 consecutive days. Diaphragm activity recovered to prehemisection levels in the Tph2+/+ and Tph2−/− mice following exposure to IH but not normoxia [Tph2+/+ 1.3 ± 0.2 (SE) vs. 0.3 ± 0.2; Tph2−/− 1.06 ± 0.1 vs. 0.3 ± 0.1, standardized to prehemisection values, P < 0.01]. Likewise, recovery of tidal volume and breathing frequency was evident, although breathing frequency values did not return to prehemisection levels within the time frame of the protocol. Partial recovery of limb motor function was also evident 2 wk after spinal cord hemisection. However, recovery was not dependent on IH or the presence of serotonin in the central nervous system. We conclude that IH promotes recovery of respiratory function but not basic motor tasks. Moreover, we conclude that spontaneous or treatment-induced recovery of respiratory and motor limb function is not dependent on serotonin in the central nervous system in a mouse model of spinal cord injury.

Poster 305 Lower Extremity Motor Function in Chronic Spinal Cord Injury After Exposure to Ibuprofen and Intermittent Hypoxia: A Randomized Trial

PM&R ◽  
2014 ◽  
Vol 6 (9) ◽  
pp. S170
Author(s):  
Meaghan M. Lynch ◽  
Sudarshan Srivatsan ◽  
Kelly Deatsch ◽  
Lynsey Duffell ◽  
Allison Kessler ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Lower Extremity ◽  
Randomized Trial ◽  
Motor Function ◽  
Intermittent Hypoxia ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

scholarly journals Motor Function in Chronic Spinal Cord Injury After Exposure to Ibuprofen and Intermittent Hypoxia

2014 ◽  
Vol 95 (10) ◽  
pp. e83
Author(s):  
Kelly Deatsch ◽  
Sudarshan Srivatsan ◽  
Meaghan Lynch ◽  
Lynsey Duffell ◽  
Allison Kessler ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Function ◽  
Intermittent Hypoxia ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury
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