scholarly journals Cytochrome P450 1B1 Is Essential For Angiotensin II‐ And Arachidonic Acid‐Induced Activation Of NADPH Oxidase In Vascular Smooth Muscle Cells Of Mice

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Chi Young Song ◽  
Nayaab Khan ◽  
Xiao Fang ◽  
Kafait Malik
Keyword(s):  
Arachidonic Acid ◽  
Cytochrome P450 ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Nadph Oxidase ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Cytochrome P450 1B1

scholarly journals INHIBITORY EFFECT OF REINIOSIDE C ON VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION INDUCED BY ANGIOTENSIN II VIA INHIBITING NADPH OXIDASE-ROS-ERK1/2-NF-KB-AP-1 PATHWAY

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E120.3-E121
Author(s):  
Dan Hong ◽  
Rui-Zheng Shi ◽  
Yong-Ping Bai ◽  
Chang-Ping Hu ◽  
Gui-Shan Tan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Nadph Oxidase ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Inhibitory Effect

scholarly journals Angiotensin II stimulates phosphorylation of high-molecular-mass cytosolic phospholipase A2 in vascular smooth-muscle cells

1994 ◽  
Vol 299 (1) ◽  
pp. 197-201 ◽  
Author(s):  
G N Rao ◽  
B Lassègue ◽  
R W Alexander ◽  
K K Griendling
Keyword(s):  
Arachidonic Acid ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Time Dependent ◽  
Arachidonic Acid Release ◽  
Acid Release

Phospholipase A2 (PLA2) may be one of the major components involved in cell signalling and proliferation, as suggested by recent studies. In this paper we show that the potent vasoconstrictor and hypertrophic agent angiotensin II (AngII) activates cytosolic PLA2 (cPLA2) in vascular smooth-muscle cells. AngII induced a rapid time-dependent release of [3H]arachidonic acid from prelabelled cells that was inhibited by mepacrine, a PLA2 inhibitor. AngII treatment of intact cells also activated a cPLA2, as measured in cell-free extracts by the release of radiolabelled arachidonic acid from exogenously added 1-stearoyl-2-[1-14C]arachidonoyl phosphatidylcholine. This AngII-stimulated cPLA2 activity was also significantly inhibited by mepacrine. AngII induced a rapid and time-dependent increase in cPLA2 phosphorylation. Protein kinase C (PKC) depletion inhibited both AngII-induced [3H]arachidonic acid release and cPLA2 phosphorylation. Together, these results suggest strongly that (1) AngII phosphorylates and activates cPLA2 in a PKC-dependent manner, and that (2) cPLA2 mediates the AngII-induced [3H]arachidonic acid release in vascular smooth-muscle cells.

scholarly journals Angiotensin II and NADPH Oxidase Increase ADMA in Vascular Smooth Muscle Cells

Hypertension ◽  
2010 ◽  
Vol 56 (3) ◽  
pp. 498-504 ◽  
Author(s):  
Zaiming Luo ◽  
Tom Teerlink ◽  
Kathy Griendling ◽  
Shakil Aslam ◽  
William J. Welch ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Nadph Oxidase ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells
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