scholarly journals Increasing Angiotensin Converting Enzyme 2 Activity in the Brain Is Anxiolytic and Dampens Activation of Hypothalamic‐Pituitary‐Adrenal Axis in Male Mice

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Lei Wang ◽  
Annette Kloet ◽  
Dipanwita Pati ◽  
Helmut Hiller ◽  
Justin Smith ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Converting Enzyme ◽  
Male Mice ◽  
Angiotensin Converting Enzyme 2 ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
The Brain ◽  
Pituitary Adrenal Axis

scholarly journals Acute hypernatremia promotes anxiolysis and attenuates stress-induced activation of the hypothalamic–pituitary–adrenal axis in male mice

2014 ◽  
Vol 136 ◽  
pp. 91-96 ◽  
Author(s):  
Justin A. Smith ◽  
Lei Wang ◽  
Helmut Hiller ◽  
Christopher T. Taylor ◽  
Annette D. de Kloet ◽  
...  
Keyword(s):  
Hypothalamic Pituitary Adrenal Axis ◽  
Male Mice ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals A Fall in Plasma Free Fatty Acid (FFA) Level Activates the Hypothalamic-Pituitary-Adrenal Axis Independent of Plasma Glucose: Evidence for Brain Sensing of Circulating FFA

Endocrinology ◽  
2012 ◽  
Vol 153 (8) ◽  
pp. 3587-3592 ◽  
Author(s):  
Young Taek Oh ◽  
Ki-Sook Oh ◽  
Insug Kang ◽  
Jang H. Youn
Keyword(s):  
Plasma Glucose ◽  
Plasma Corticosterone ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Plasma Acth ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Adenosine Receptor Agonist ◽  
Plasma Ffa ◽  
The Brain ◽  
Pituitary Adrenal Axis

The brain responds to a fall in blood glucose by activating neuroendocrine mechanisms for its restoration. It is unclear whether the brain also responds to a fall in plasma free fatty acids (FFA) to activate mechanisms for its restoration. We examined whether lowering plasma FFA increases plasma corticosterone or catecholamine levels and, if so, whether the brain is involved in these responses. Plasma FFA levels were lowered in rats with three independent antilipolytic agents: nicotinic acid (NA), insulin, and the A1 adenosine receptor agonist SDZ WAG 994 with plasma glucose clamped at basal levels. Lowering plasma FFA with these agents all increased plasma corticosterone, but not catecholamine, within 1 h, accompanied by increases in plasma ACTH. These increases in ACTH or corticosterone were abolished when falls in plasma FFA were prevented by Intralipid during NA or insulin infusion. In addition, the NA-induced increases in plasma ACTH were completely prevented by administration of SSR149415, an arginine vasopressin receptor antagonist, demonstrating that the hypothalamus is involved in these responses. Taken together, the present data suggest that the brain may sense a fall in plasma FFA levels and activate the hypothalamic-pituitary-adrenal axis to increase plasma ACTH and corticosterone, which would help restore FFA levels. Thus, the brain may be involved in the sensing and control of circulating FFA levels.

Activation of the Hypothalamic- Pituitary-Adrenal Axis in IL-1β-Converting Enzyme-Deficient Mice

2000 ◽  
Vol 7 (4) ◽  
pp. 189-194 ◽  
Author(s):  
Stéphane Liège ◽  
Elisabeth Moze ◽  
Keith W. Kelley ◽  
Patricia Parnet ◽  
Pierre J. Neveu
Keyword(s):  
Hypothalamic Pituitary Adrenal Axis ◽  
Converting Enzyme ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Enzyme Deficient ◽  
Deficient Mice ◽  
Pituitary Adrenal Axis
Sign in / Sign up

Export Citation Format

Share Document