Room B, 10/17/2000 9: 00 AM - 11: 00 AM (PS) Does Cardiac Surgery with Cardio Pulmonary Bypass Affect Renal Function in Patients with Preoperative Renal Impairment? 

2000 ◽  
Vol 93 (3A) ◽  
pp. A-164
Author(s):  
Bert Loef ◽  
Anne Epema ◽  
Rob Henning ◽  
Wim van Oeveren ◽  
Gerjan Navis
Keyword(s):  
Renal Function ◽  
Cardiac Surgery ◽  
Renal Impairment ◽  
Cardio Pulmonary Bypass ◽  
Pulmonary Bypass

Hormonal variations and renal function during cardiac surgery with cardio pulmonary bypass

1989 ◽  
Vol 3 (5) ◽  
pp. 61
Author(s):  
I. Deswarte ◽  
E. Donzeau-Gouge ◽  
S. Grill ◽  
D. Tenehaus ◽  
G. N'guyen ◽  
...  
Keyword(s):  
Renal Function ◽  
Cardiac Surgery ◽  
Cardio Pulmonary Bypass ◽  
Pulmonary Bypass

Prognostic Value of GDF-15 in Predicting Prolonged Intensive Care Stay following Cardiac Surgery: A Retrospective Case-Control Study

2021 ◽  
Author(s):  
Henry Barton ◽  
Elisabeth Zechendorf ◽  
Dirk Ostareck ◽  
Antje Ostareck-Lederer ◽  
Christian Stoppe ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Intensive Care ◽  
Confidence Interval ◽  
Prediction Models ◽  
Unit Length ◽  
Icu Stay ◽  
Intensive Care Stay ◽  
Cardio Pulmonary Bypass ◽  
Prolonged Icu Stay ◽  
Pulmonary Bypass

Abstract Background: Predicting intensive care unit length of stay and outcome following cardiac surgery is currently based on clinical parameters. Novel biomarkers could be employed to improve the prediction models. Methods: We performed a qualitative cytokine screening array to identify highly expressed biomarkers in preoperative blood samples of cardiac surgery patients. After identification of one highly expressed biomarker, growth differentiation factor 15 (GDF-15), a quantitative ELISA was undertaken. Preoperative levels of GDF-15 were compared in regard to duration of intensive care stay, cardio-pulmonary bypass time and indicators of organ dysfunction.Results: Preoperatively, GDF-15 was highly expressed in addition to several less highly expressed other biomarkers. After qualitative analysis we could show that preoperatively raised levels of GDF-15 was positively associated with prolonged ICU stay exceeding 48 h (median 713 versus 1041 pg/ml, p = 0.003). It was also associated with prolonged mechanical ventilation and rates of severe sepsis but not with dialysis rates or cardio-pulmonary bypass time. In univariate regression, raised GDF-15 levels were predictive of a prolonged ICU stay (OR 1.01, 95% Confidence Interval 1 – 1.02, p= 0.029). On ROC curves, GDF-15 was found to predict prolonged ICU stay (AUC= 0.86, 95% Confidence Interval 0.71 – 0.99, p= 0.003).Conclusion: GDF-15 showed potential as predictor of prolonged intensive care stay following cardiac surgery, which might be valuable for risk stratification models.

scholarly journals Efficacy of Statin Therapy Related to Baseline Renal Function in Patients with Rheumatic Heart Disease Undergoing Cardiac Surgery

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Rongjun Zou ◽  
Wanting Shi ◽  
Jun Tao ◽  
Xifeng Lin ◽  
Dingwen Zhang ◽  
...  
Keyword(s):  
Renal Function ◽  
Cardiac Surgery ◽  
Heart Disease ◽  
Renal Impairment ◽  
Hospital Stay ◽  
Normal Renal Function ◽  
Icu Stay ◽  
Drainage Time ◽  
Baseline Renal Function ◽  
Rheumatic Heart

Background. Renal impairment increases the risk of cardiovascular events and perioperative complications in patients with heart valve disease. This study aimed to determine the perioperative benefit of statin treatment related to baseline renal function in patients with rheumatic heart disease (RHD) who had cardiac surgery. Methods and Results. We performed a retrospective study on 136 patients with RHD who underwent valve replacement surgery. The mean age of the patients was 56.2 years, 59.6% were female, 8.8% patients had diabetes mellitus, and 27.2% of patients had hypertension. Overall, 3 patients died, 2 underwent reoperation, and 25 underwent thoracentesis during the study period. For patients with renal impairment, there was a higher risk of thoracic puncture (odds ratio [OR]: 3.33; 95% confidence interval [CI]: 1.36, 8.11; P<0.01) and a longer time of drainage (difference in means: 1; 95% CI: 0.88, 1.12; P<0.01), intensive care unit (ICU) stay (difference in means: 0.2; 95% CI: 0.17, 0.23; P=0.02), and hospital stay (difference in means: 6.6; 95% CI: 6.15, 7.05; P<0.01) compared with normal renal function. Furthermore, statins were associated with a reduction in drainage time (difference in means: −1.50; 95% CI: −1.86, −1.14; P=0.02), ICU stay (difference in means: −0.30; 95% CI: −0.40, −0.20; P=0.05), and hospital stay (difference in means: −5.40; 95% CI: −6.57, −4.23; P<0.01) in patients with renal impairment (interaction, P≤0.05 for all), but not in those with normal renal function. Conclusion. Statins have a greater clinical benefit in perioperative cardiac surgery with renal impairment. Statins are associated with a comparatively lower risk of thoracic puncture, as well as a reduced trend toward a reduction in drainage time, ICU stay, and hospital stay.

scholarly journals Pharmacodynamics of doxacurium during cardiac surgery with hypothermic cardio-pulmonary bypass

1996 ◽  
Vol 43 (2) ◽  
pp. 134-140 ◽  
Author(s):  
Paul McDonagh ◽  
Jean-Yves Dupuis ◽  
Michael Curran ◽  
John Kitts ◽  
J. Earl Wynands
Keyword(s):  
Cardiac Surgery ◽  
Cardio Pulmonary Bypass ◽  
Pulmonary Bypass

scholarly journals Microvascular response to cardio-pulmonary bypass during cardiac surgery

2008 ◽  
Vol 55 (S1) ◽  
pp. 4753421-4753422
Author(s):  
David Bracco ◽  
Marie-Claude Bluteau ◽  
Jean-François oliver ◽  
Dominique Shum Tim ◽  
Christo Tchervenkov ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Microvascular Response ◽  
Cardio Pulmonary Bypass ◽  
Pulmonary Bypass

scholarly journals Lack of Renoprotective Effects of Dopamine and Furosemide during Cardiac Surgery

2000 ◽  
Vol 11 (1) ◽  
pp. 97-104 ◽  
Author(s):  
ANDREA LASSNIGG ◽  
EVA DONNER ◽  
GEORG GRUBHOFER ◽  
ELISABETH PRESTERL ◽  
WILFRED DRUML ◽  
...  
Keyword(s):  
Renal Function ◽  
Cardiac Surgery ◽  
Renal Impairment ◽  
Continuous Infusion ◽  
Renal Dysfunction ◽  
Controlled Trial ◽  
Free Water ◽  
Renal Protection ◽  
Double Blind ◽  
Group D

Abstract. Because development of acute renal failure is one of the most potent predictors of outcome in cardiac surgery patients, the prevention of renal dysfunction is of utmost importance in perioperative care. In a double-blind randomized controlled trial, the effectiveness of dopamine or furosemide in prevention of renal impairment after cardiac surgery was evaluated. A total of 126 patients with preoperatively normal renal function undergoing elective cardiac surgery received a continuous infusion of either “renal-dose” dopamine (2 μg/kg per min) (group D), furosemide (0.5 μg/kg per min) (group F), or isotonic sodium chloride as placebo (group P), starting at the beginning of surgery and continuing for 48 h or until discharge from the intensive care unit, whichever came first. Renal function parameters and the maximal increase of serum creatinine above baseline value within 48 h (▵Creamax) were determined. The increase in plasma creatinine was twice as high in group F as in groups D and P (P < 0.01). Acute renal injury (defined as ▵Creamax >0.5 mg/dl) occurred more frequently in group F (six of 41 patients) than in group D (one of 42) and group P (zero of 40) (P < 0.01). (The difference between group D and group P was not significant.) Creatinine clearance was lower in group F (P < 0.05). Two patients in group F required renal replacement therapy. The mean volume of infused fluids, blood urea nitrogen, serum sodium, serum potassium, and osmolar- and free-water clearance was similar in all groups. It was shown that continuous infusion of dopamine for renal protection was ineffective and was not superior to placebo in preventing postoperative dysfunction after cardiac surgery. In contrast, continuous infusion of furosemide was associated with the highest rate of renal impairment. Thus, renal-dose dopamine is ineffective and furosemide is even detrimental in the protection of renal dysfunction after cardiac surgery.

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