Genetic susceptibility–molecular epidemiology of head and neck cancer

2002 ◽  
Vol 14 (3) ◽  
pp. 310-317 ◽  
Author(s):  
Erich M. Sturgis ◽  
Qingyi Wei
Keyword(s):  
Head And Neck Cancer ◽  
Molecular Epidemiology ◽  
Head And Neck ◽  
Genetic Susceptibility ◽  
Neck Cancer

scholarly journals Molecular Epidemiology and Retinoid Chemoprevention of Head and Neck Cancer

1997 ◽  
Vol 89 (3) ◽  
pp. 199-211 ◽  
Author(s):  
F. R. Khuri ◽  
W. K. Hong ◽  
S. M. Lippman ◽  
M. R. Spitz ◽  
R. Lotan
Keyword(s):  
Head And Neck Cancer ◽  
Molecular Epidemiology ◽  
Head And Neck ◽  
Neck Cancer

Molecular Epidemiology of Head and Neck Cancer

2003 ◽  
pp. 213-226
Author(s):  
Qingyi Wei ◽  
Peter Shields ◽  
Erich M. Sturgis ◽  
Margaret R. Spitz
Keyword(s):  
Head And Neck Cancer ◽  
Molecular Epidemiology ◽  
Head And Neck ◽  
Neck Cancer

The relationship between genetic susceptibility to head and neck cancer with the expression of common fragile sites

Head & Neck ◽  
2000 ◽  
Vol 22 (6) ◽  
pp. 591-598 ◽  
Author(s):  
�nal Egeli ◽  
L�tfi �zkan ◽  
Berrin Tunca ◽  
Sibel Kahraman ◽  
G�l?ah �e�ener ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Genetic Susceptibility ◽  
Neck Cancer ◽  
Fragile Sites ◽  
Common Fragile Sites ◽  
The Relationship

scholarly journals Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 493 ◽  
Author(s):  
Javier Fernández-Mateos ◽  
Raquel Seijas-Tamayo ◽  
Juan Adansa Klain ◽  
Miguel Pastor Borgoñón ◽  
Elisabeth Pérez-Ruiz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dna Repair ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Genetic Susceptibility ◽  
Neck Cancer ◽  
Spanish Population ◽  
Candidate Snps ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis). Genotyping was performed using TaqMan probes or restriction fragment length assays in peripheral blood DNA. In addition, 259 paired controls were also evaluated with the same risk factors for each specific location. Nine SNPs in DNA repair (ERCC1 rs11615, ERCC2 rs13181), inflammatory (IL2 rs2069762, IL6 rs1800795), oxidative (NFE2L2 rs13035806 and rs2706110) and apoptotic genes (TP53 rs1042522, MDM2 rs2279744, BCL2 rs2279115) were differently associated with HNSCC susceptibility by location. Some of these SNPs were not described before in this tumour type. In conclusion, we describe several SNPs associated with HNC in a Spanish population.

Genetic Susceptibility to Head and Neck Cancer: Interaction Between Nutrition and Mutagen Sensitivity

1997 ◽  
Vol 107 (6) ◽  
pp. 765-781 ◽  
Author(s):  
Stimson P. Schantz ◽  
Zuo-Feng Zhang ◽  
Margaret S. Spitz ◽  
Ming Sun ◽  
Tao C. Hsu
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Genetic Susceptibility ◽  
Neck Cancer ◽  
Mutagen Sensitivity
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