Genotyping of Candida albicans isolates from oropharyngeal candidiasis in head and neck cancer patients in Iran: Molecular epidemiology and SAP2 gene expression

2019 ◽  
Vol 29 (4) ◽  
pp. 310-316 ◽  
Author(s):  
Z. Jahanshiri ◽  
S. Manifar ◽  
F. Hatami ◽  
F. Arastehnazar ◽  
M. Shams-Ghahfarokhi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Head And Neck Cancer ◽  
Candida Albicans ◽  
Molecular Epidemiology ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Oropharyngeal Candidiasis

Aspartyl Proteinase and Phospholipase Activities of Candida albicans Isolated From Oropharyngeal Candidiasis in Head and Neck Cancer Patients

2020 ◽  
Vol 13 (9) ◽  
Author(s):  
Mohsen Ilkhanizadeh-Qomi ◽  
Sepideh Nejatbakhsh ◽  
Zahra Jahanshiri ◽  
Mehdi Razzaghi-Abyaneh
Keyword(s):  
Head And Neck Cancer ◽  
Candida Albicans ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Fungal Infections ◽  
Hydrolytic Enzymes ◽  
Oropharyngeal Candidiasis ◽  
Gene Expressions ◽  
Expression Levels

Background: Candida albicans is one of the most important members of the human normal flora that can cause opportunistic fungal infections. Hydrolytic enzymes are one of the main virulence factors in the pathogenesis of Candida species. Objectives: This study was carried out to determine proteolytic activities, and their related gene expressions in C. albicans isolates obtained from oropharyngeal candidiasis in head and neck cancer patients. Methods: Thirty-two C. albicans clinical isolates were included in this study. Secreted aspartyl protease and phospholipase activities were analyzed by appropriate agar media and precipitation zones. The expression levels of SAP1, 3 and PLB1, 2 genes were evaluated by real-time PCR. Results: All the 32 isolates exhibited proteinase activity while 28 of them showed phospholipase activity. All the strains possessed all SAPs genes; however, PLBs genes were not expressed in four isolates. Conclusions: Our findings demonstrated that the clinical strains of C. albicans had strong proteolytic activity and high expression levels of the pertaining genes.

Oropharyngeal candidiasis in head and neck cancer patients treated with radiation: update 2011

2011 ◽  
Vol 19 (6) ◽  
pp. 737-744 ◽  
Author(s):  
Rene-Jean Bensadoun ◽  
Lauren L. Patton ◽  
Rajesh V. Lalla ◽  
Joel B. Epstein
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Oropharyngeal Candidiasis

Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 6017-6017 ◽  
Author(s):  
Tanguy Y. Seiwert ◽  
Barbara Burtness ◽  
Jared Weiss ◽  
Joseph Paul Eder ◽  
Jennifer Yearley ◽  
...  
Keyword(s):  
Gene Expression ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Gene Expression Signatures

Abstract 4257: Predicting fatigue levels of head and neck cancer patients with gene expression using machine learning

2018 ◽  
Author(s):  
Ronald C. Eldridge ◽  
Andrew H. Miller ◽  
Deborah W. Bruner ◽  
Jonathan J. Beitler ◽  
Kristin A. Higgins ◽  
...  
Keyword(s):  
Gene Expression ◽  
Machine Learning ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer

scholarly journals Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Siv K Bøhn ◽  
Kjell M Russnes ◽  
Amrit K Sakhi ◽  
Magne Thoresen ◽  
Marit Holden ◽  
...  
Keyword(s):  
Gene Expression ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Blood Cells
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